Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study
INTRODUCTION To support clinical trial designs focused on early interventions, our study determined reliable early amyloid‐β (Aβ) accumulation based on Centiloids (CL) in pre‐dementia populations. METHODS A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease–Progn...
Gespeichert in:
| Veröffentlicht in: | Alzheimer's & dementia 2024-05, Vol.20 (5), p.3429-3441 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 3441 |
|---|---|
| container_issue | 5 |
| container_start_page | 3429 |
| container_title | Alzheimer's & dementia |
| container_volume | 20 |
| creator | Bollack, Ariane Collij, Lyduine E. García, David Vállez Shekari, Mahnaz Altomare, Daniele Payoux, Pierre Dubois, Bruno Grau‐Rivera, Oriol Boada, Mercè Marquié, Marta Nordberg, Agneta Walker, Zuzana Scheltens, Philip Schöll, Michael Wolz, Robin Schott, Jonathan M. Gismondi, Rossella Stephens, Andrew Buckley, Christopher Frisoni, Giovanni B. Hanseeuw, Bernard Visser, Pieter Jelle Vandenberghe, Rik Drzezga, Alexander Yaqub, Maqsood Boellaard, Ronald Gispert, Juan Domingo Markiewicz, Pawel Cash, David M. Farrar, Gill Barkhof, Frederik |
| description | INTRODUCTION
To support clinical trial designs focused on early interventions, our study determined reliable early amyloid‐β (Aβ) accumulation based on Centiloids (CL) in pre‐dementia populations.
METHODS
A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease–Prognostic and Natural History Study (AMYPAD‐PNHS) and Insight46 who underwent [18F]flutemetamol, [18F]florbetaben or [18F]florbetapir amyloid‐PET were included. A normative strategy was used to define reliable accumulation by estimating the 95th percentile of longitudinal measurements in sub‐populations (NPNHS = 101/750, NInsight46 = 35/382) expected to remain stable over time. The baseline CL threshold that optimally predicts future accumulation was investigated using precision‐recall analyses. Accumulation rates were examined using linear mixed‐effect models.
RESULTS
Reliable accumulation in the PNHS was estimated to occur at >3.0 CL/year. Baseline CL of 16 [12,19] best predicted future Aβ‐accumulators. Rates of amyloid accumulation were tracer‐independent, lower for APOE ε4 non‐carriers, and for subjects with higher levels of education.
DISCUSSION
Our results support a 12–20 CL window for inclusion into early secondary prevention studies. Reliable accumulation definition warrants further investigations. |
| doi_str_mv | 10.1002/alz.13761 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_856908</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3034243112</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5551-a466bffdf7121ca03d812c9721df12d22dfb42211f836f1ecefafd07690045ad3</originalsourceid><addsrcrecordid>eNp9kkmPEzEQRlsIxCxw4A8gH-GQGZeXXrigKDBkpAAjlgNcLMdLx-Buh3Z3ovDrcRYCgzQcLFtVr55l68uyJ4AvAGNyKf3PC6BFDveyU-CcjDgpqvvHc45PsrMYv2HMcAn8YXZCS14wWrDTbH3drkzsXS1719aoM97JuTdINhsfnEZSqaEZfOqGFrkWTUzbu20nvkAfTBx8H5HtQoP6hUHjt19uxq_QTRfqNiSpQrLV6J3sh056NHWxD90GfewHvXmUPbDSR_P4sJ9nn69ef5pMR7P3b64n49lIcc5hJFmez63VtgACSmKqSyCqKghoC0QTou2cEQJgS5pbMMpYaTUu8io9lktNz7PR3hvXZjnMxbJzjew2IkgnDqXv6WREydNMmfjZnbwflmnN09oNFDRXuKwEKG0EkzIX0kIujJSSKqoYY9V_r6-TLpXqnY3SklRb_uWeT3BjtEq_nb7u1tjtTusWog4rAYArzihOhud7w-Kfuel4JrY1zHKCGeAVJPbZ4bYu_BhSDETjojLey9aEIYqkY4RRAPJHq7oQY2fs0Q1YbEMoUgjFLoSJffr3I47k79Ql4HIPrJ03m7tNYjz7ulf-Ajxi6XY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3034243112</pqid></control><display><type>article</type><title>Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><source>SWEPUB Freely available online</source><source>PubMed Central Open Access</source><creator>Bollack, Ariane ; Collij, Lyduine E. ; García, David Vállez ; Shekari, Mahnaz ; Altomare, Daniele ; Payoux, Pierre ; Dubois, Bruno ; Grau‐Rivera, Oriol ; Boada, Mercè ; Marquié, Marta ; Nordberg, Agneta ; Walker, Zuzana ; Scheltens, Philip ; Schöll, Michael ; Wolz, Robin ; Schott, Jonathan M. ; Gismondi, Rossella ; Stephens, Andrew ; Buckley, Christopher ; Frisoni, Giovanni B. ; Hanseeuw, Bernard ; Visser, Pieter Jelle ; Vandenberghe, Rik ; Drzezga, Alexander ; Yaqub, Maqsood ; Boellaard, Ronald ; Gispert, Juan Domingo ; Markiewicz, Pawel ; Cash, David M. ; Farrar, Gill ; Barkhof, Frederik</creator><creatorcontrib>Bollack, Ariane ; Collij, Lyduine E. ; García, David Vállez ; Shekari, Mahnaz ; Altomare, Daniele ; Payoux, Pierre ; Dubois, Bruno ; Grau‐Rivera, Oriol ; Boada, Mercè ; Marquié, Marta ; Nordberg, Agneta ; Walker, Zuzana ; Scheltens, Philip ; Schöll, Michael ; Wolz, Robin ; Schott, Jonathan M. ; Gismondi, Rossella ; Stephens, Andrew ; Buckley, Christopher ; Frisoni, Giovanni B. ; Hanseeuw, Bernard ; Visser, Pieter Jelle ; Vandenberghe, Rik ; Drzezga, Alexander ; Yaqub, Maqsood ; Boellaard, Ronald ; Gispert, Juan Domingo ; Markiewicz, Pawel ; Cash, David M. ; Farrar, Gill ; Barkhof, Frederik ; AMYPAD consortium ; AMYPAD Consortium</creatorcontrib><description>INTRODUCTION
To support clinical trial designs focused on early interventions, our study determined reliable early amyloid‐β (Aβ) accumulation based on Centiloids (CL) in pre‐dementia populations.
METHODS
A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease–Prognostic and Natural History Study (AMYPAD‐PNHS) and Insight46 who underwent [18F]flutemetamol, [18F]florbetaben or [18F]florbetapir amyloid‐PET were included. A normative strategy was used to define reliable accumulation by estimating the 95th percentile of longitudinal measurements in sub‐populations (NPNHS = 101/750, NInsight46 = 35/382) expected to remain stable over time. The baseline CL threshold that optimally predicts future accumulation was investigated using precision‐recall analyses. Accumulation rates were examined using linear mixed‐effect models.
RESULTS
Reliable accumulation in the PNHS was estimated to occur at >3.0 CL/year. Baseline CL of 16 [12,19] best predicted future Aβ‐accumulators. Rates of amyloid accumulation were tracer‐independent, lower for APOE ε4 non‐carriers, and for subjects with higher levels of education.
DISCUSSION
Our results support a 12–20 CL window for inclusion into early secondary prevention studies. Reliable accumulation definition warrants further investigations.</description><identifier>ISSN: 1552-5260</identifier><identifier>ISSN: 1552-5279</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1002/alz.13761</identifier><identifier>PMID: 38574374</identifier><language>eng</language><publisher>United States: Alzheimer's Association / Wiley</publisher><subject>Aged ; Alzheimer Disease - diagnostic imaging ; Alzheimer Disease - metabolism ; Alzheimer's ; amyloid ; Amyloid beta-Peptides - metabolism ; Aniline Compounds ; Benzothiazoles ; Brain - diagnostic imaging ; Brain - metabolism ; Centiloid ; Clinical Medicine ; Female ; Geriatrics ; Geriatrik ; Humans ; Klinisk medicin ; Life Sciences ; longitudinal PET ; Longitudinal Studies ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Middle Aged ; Neurosciences ; Neurovetenskaper ; Positron-Emission Tomography ; Prognosis ; quantification ; reliable accumulation ; Stilbenes</subject><ispartof>Alzheimer's & dementia, 2024-05, Vol.20 (5), p.3429-3441</ispartof><rights>2024 The Authors. published by Wiley Periodicals LLC on behalf of Alzheimer's Association.</rights><rights>2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.</rights><rights>Attribution</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5551-a466bffdf7121ca03d812c9721df12d22dfb42211f836f1ecefafd07690045ad3</cites><orcidid>0000-0003-2617-3009 ; 0000-0002-0660-0950 ; 0000-0003-3543-3706 ; 0000-0003-1336-6768 ; 0000-0001-6263-1762 ; 0000-0003-3308-3167 ; 0000-0003-1905-8993 ; 0000-0001-7346-8200 ; 0000-0002-3114-0773 ; 0000-0002-9169-7530 ; 0000-0002-6155-0642 ; 0000-0001-7833-616X ; 0000-0001-5052-6586 ; 0000-0002-3102-6778 ; 0000-0002-4730-5341</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11095430/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11095430/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38574374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://ut3-toulouseinp.hal.science/hal-04620410$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/338299$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/8736c089-1cde-4aa6-af16-eaaa3c3c4449$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:155392713$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Bollack, Ariane</creatorcontrib><creatorcontrib>Collij, Lyduine E.</creatorcontrib><creatorcontrib>García, David Vállez</creatorcontrib><creatorcontrib>Shekari, Mahnaz</creatorcontrib><creatorcontrib>Altomare, Daniele</creatorcontrib><creatorcontrib>Payoux, Pierre</creatorcontrib><creatorcontrib>Dubois, Bruno</creatorcontrib><creatorcontrib>Grau‐Rivera, Oriol</creatorcontrib><creatorcontrib>Boada, Mercè</creatorcontrib><creatorcontrib>Marquié, Marta</creatorcontrib><creatorcontrib>Nordberg, Agneta</creatorcontrib><creatorcontrib>Walker, Zuzana</creatorcontrib><creatorcontrib>Scheltens, Philip</creatorcontrib><creatorcontrib>Schöll, Michael</creatorcontrib><creatorcontrib>Wolz, Robin</creatorcontrib><creatorcontrib>Schott, Jonathan M.</creatorcontrib><creatorcontrib>Gismondi, Rossella</creatorcontrib><creatorcontrib>Stephens, Andrew</creatorcontrib><creatorcontrib>Buckley, Christopher</creatorcontrib><creatorcontrib>Frisoni, Giovanni B.</creatorcontrib><creatorcontrib>Hanseeuw, Bernard</creatorcontrib><creatorcontrib>Visser, Pieter Jelle</creatorcontrib><creatorcontrib>Vandenberghe, Rik</creatorcontrib><creatorcontrib>Drzezga, Alexander</creatorcontrib><creatorcontrib>Yaqub, Maqsood</creatorcontrib><creatorcontrib>Boellaard, Ronald</creatorcontrib><creatorcontrib>Gispert, Juan Domingo</creatorcontrib><creatorcontrib>Markiewicz, Pawel</creatorcontrib><creatorcontrib>Cash, David M.</creatorcontrib><creatorcontrib>Farrar, Gill</creatorcontrib><creatorcontrib>Barkhof, Frederik</creatorcontrib><creatorcontrib>AMYPAD consortium</creatorcontrib><creatorcontrib>AMYPAD Consortium</creatorcontrib><title>Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study</title><title>Alzheimer's & dementia</title><addtitle>Alzheimers Dement</addtitle><description>INTRODUCTION
To support clinical trial designs focused on early interventions, our study determined reliable early amyloid‐β (Aβ) accumulation based on Centiloids (CL) in pre‐dementia populations.
METHODS
A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease–Prognostic and Natural History Study (AMYPAD‐PNHS) and Insight46 who underwent [18F]flutemetamol, [18F]florbetaben or [18F]florbetapir amyloid‐PET were included. A normative strategy was used to define reliable accumulation by estimating the 95th percentile of longitudinal measurements in sub‐populations (NPNHS = 101/750, NInsight46 = 35/382) expected to remain stable over time. The baseline CL threshold that optimally predicts future accumulation was investigated using precision‐recall analyses. Accumulation rates were examined using linear mixed‐effect models.
RESULTS
Reliable accumulation in the PNHS was estimated to occur at >3.0 CL/year. Baseline CL of 16 [12,19] best predicted future Aβ‐accumulators. Rates of amyloid accumulation were tracer‐independent, lower for APOE ε4 non‐carriers, and for subjects with higher levels of education.
DISCUSSION
Our results support a 12–20 CL window for inclusion into early secondary prevention studies. Reliable accumulation definition warrants further investigations.</description><subject>Aged</subject><subject>Alzheimer Disease - diagnostic imaging</subject><subject>Alzheimer Disease - metabolism</subject><subject>Alzheimer's</subject><subject>amyloid</subject><subject>Amyloid beta-Peptides - metabolism</subject><subject>Aniline Compounds</subject><subject>Benzothiazoles</subject><subject>Brain - diagnostic imaging</subject><subject>Brain - metabolism</subject><subject>Centiloid</subject><subject>Clinical Medicine</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Geriatrik</subject><subject>Humans</subject><subject>Klinisk medicin</subject><subject>Life Sciences</subject><subject>longitudinal PET</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>Neurosciences</subject><subject>Neurovetenskaper</subject><subject>Positron-Emission Tomography</subject><subject>Prognosis</subject><subject>quantification</subject><subject>reliable accumulation</subject><subject>Stilbenes</subject><issn>1552-5260</issn><issn>1552-5279</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp9kkmPEzEQRlsIxCxw4A8gH-GQGZeXXrigKDBkpAAjlgNcLMdLx-Buh3Z3ovDrcRYCgzQcLFtVr55l68uyJ4AvAGNyKf3PC6BFDveyU-CcjDgpqvvHc45PsrMYv2HMcAn8YXZCS14wWrDTbH3drkzsXS1719aoM97JuTdINhsfnEZSqaEZfOqGFrkWTUzbu20nvkAfTBx8H5HtQoP6hUHjt19uxq_QTRfqNiSpQrLV6J3sh056NHWxD90GfewHvXmUPbDSR_P4sJ9nn69ef5pMR7P3b64n49lIcc5hJFmez63VtgACSmKqSyCqKghoC0QTou2cEQJgS5pbMMpYaTUu8io9lktNz7PR3hvXZjnMxbJzjew2IkgnDqXv6WREydNMmfjZnbwflmnN09oNFDRXuKwEKG0EkzIX0kIujJSSKqoYY9V_r6-TLpXqnY3SklRb_uWeT3BjtEq_nb7u1tjtTusWog4rAYArzihOhud7w-Kfuel4JrY1zHKCGeAVJPbZ4bYu_BhSDETjojLey9aEIYqkY4RRAPJHq7oQY2fs0Q1YbEMoUgjFLoSJffr3I47k79Ql4HIPrJ03m7tNYjz7ulf-Ajxi6XY</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Bollack, Ariane</creator><creator>Collij, Lyduine E.</creator><creator>García, David Vállez</creator><creator>Shekari, Mahnaz</creator><creator>Altomare, Daniele</creator><creator>Payoux, Pierre</creator><creator>Dubois, Bruno</creator><creator>Grau‐Rivera, Oriol</creator><creator>Boada, Mercè</creator><creator>Marquié, Marta</creator><creator>Nordberg, Agneta</creator><creator>Walker, Zuzana</creator><creator>Scheltens, Philip</creator><creator>Schöll, Michael</creator><creator>Wolz, Robin</creator><creator>Schott, Jonathan M.</creator><creator>Gismondi, Rossella</creator><creator>Stephens, Andrew</creator><creator>Buckley, Christopher</creator><creator>Frisoni, Giovanni B.</creator><creator>Hanseeuw, Bernard</creator><creator>Visser, Pieter Jelle</creator><creator>Vandenberghe, Rik</creator><creator>Drzezga, Alexander</creator><creator>Yaqub, Maqsood</creator><creator>Boellaard, Ronald</creator><creator>Gispert, Juan Domingo</creator><creator>Markiewicz, Pawel</creator><creator>Cash, David M.</creator><creator>Farrar, Gill</creator><creator>Barkhof, Frederik</creator><general>Alzheimer's Association / Wiley</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>F1U</scope><scope>AGCHP</scope><scope>D8T</scope><scope>D95</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0003-2617-3009</orcidid><orcidid>https://orcid.org/0000-0002-0660-0950</orcidid><orcidid>https://orcid.org/0000-0003-3543-3706</orcidid><orcidid>https://orcid.org/0000-0003-1336-6768</orcidid><orcidid>https://orcid.org/0000-0001-6263-1762</orcidid><orcidid>https://orcid.org/0000-0003-3308-3167</orcidid><orcidid>https://orcid.org/0000-0003-1905-8993</orcidid><orcidid>https://orcid.org/0000-0001-7346-8200</orcidid><orcidid>https://orcid.org/0000-0002-3114-0773</orcidid><orcidid>https://orcid.org/0000-0002-9169-7530</orcidid><orcidid>https://orcid.org/0000-0002-6155-0642</orcidid><orcidid>https://orcid.org/0000-0001-7833-616X</orcidid><orcidid>https://orcid.org/0000-0001-5052-6586</orcidid><orcidid>https://orcid.org/0000-0002-3102-6778</orcidid><orcidid>https://orcid.org/0000-0002-4730-5341</orcidid></search><sort><creationdate>202405</creationdate><title>Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study</title><author>Bollack, Ariane ; Collij, Lyduine E. ; García, David Vállez ; Shekari, Mahnaz ; Altomare, Daniele ; Payoux, Pierre ; Dubois, Bruno ; Grau‐Rivera, Oriol ; Boada, Mercè ; Marquié, Marta ; Nordberg, Agneta ; Walker, Zuzana ; Scheltens, Philip ; Schöll, Michael ; Wolz, Robin ; Schott, Jonathan M. ; Gismondi, Rossella ; Stephens, Andrew ; Buckley, Christopher ; Frisoni, Giovanni B. ; Hanseeuw, Bernard ; Visser, Pieter Jelle ; Vandenberghe, Rik ; Drzezga, Alexander ; Yaqub, Maqsood ; Boellaard, Ronald ; Gispert, Juan Domingo ; Markiewicz, Pawel ; Cash, David M. ; Farrar, Gill ; Barkhof, Frederik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5551-a466bffdf7121ca03d812c9721df12d22dfb42211f836f1ecefafd07690045ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Alzheimer Disease - diagnostic imaging</topic><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer's</topic><topic>amyloid</topic><topic>Amyloid beta-Peptides - metabolism</topic><topic>Aniline Compounds</topic><topic>Benzothiazoles</topic><topic>Brain - diagnostic imaging</topic><topic>Brain - metabolism</topic><topic>Centiloid</topic><topic>Clinical Medicine</topic><topic>Female</topic><topic>Geriatrics</topic><topic>Geriatrik</topic><topic>Humans</topic><topic>Klinisk medicin</topic><topic>Life Sciences</topic><topic>longitudinal PET</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical and Health Sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>Neurosciences</topic><topic>Neurovetenskaper</topic><topic>Positron-Emission Tomography</topic><topic>Prognosis</topic><topic>quantification</topic><topic>reliable accumulation</topic><topic>Stilbenes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bollack, Ariane</creatorcontrib><creatorcontrib>Collij, Lyduine E.</creatorcontrib><creatorcontrib>García, David Vállez</creatorcontrib><creatorcontrib>Shekari, Mahnaz</creatorcontrib><creatorcontrib>Altomare, Daniele</creatorcontrib><creatorcontrib>Payoux, Pierre</creatorcontrib><creatorcontrib>Dubois, Bruno</creatorcontrib><creatorcontrib>Grau‐Rivera, Oriol</creatorcontrib><creatorcontrib>Boada, Mercè</creatorcontrib><creatorcontrib>Marquié, Marta</creatorcontrib><creatorcontrib>Nordberg, Agneta</creatorcontrib><creatorcontrib>Walker, Zuzana</creatorcontrib><creatorcontrib>Scheltens, Philip</creatorcontrib><creatorcontrib>Schöll, Michael</creatorcontrib><creatorcontrib>Wolz, Robin</creatorcontrib><creatorcontrib>Schott, Jonathan M.</creatorcontrib><creatorcontrib>Gismondi, Rossella</creatorcontrib><creatorcontrib>Stephens, Andrew</creatorcontrib><creatorcontrib>Buckley, Christopher</creatorcontrib><creatorcontrib>Frisoni, Giovanni B.</creatorcontrib><creatorcontrib>Hanseeuw, Bernard</creatorcontrib><creatorcontrib>Visser, Pieter Jelle</creatorcontrib><creatorcontrib>Vandenberghe, Rik</creatorcontrib><creatorcontrib>Drzezga, Alexander</creatorcontrib><creatorcontrib>Yaqub, Maqsood</creatorcontrib><creatorcontrib>Boellaard, Ronald</creatorcontrib><creatorcontrib>Gispert, Juan Domingo</creatorcontrib><creatorcontrib>Markiewicz, Pawel</creatorcontrib><creatorcontrib>Cash, David M.</creatorcontrib><creatorcontrib>Farrar, Gill</creatorcontrib><creatorcontrib>Barkhof, Frederik</creatorcontrib><creatorcontrib>AMYPAD consortium</creatorcontrib><creatorcontrib>AMYPAD Consortium</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Göteborgs universitet</collection><collection>SWEPUB Lunds universitet full text</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Lunds universitet</collection><collection>SwePub Articles full text</collection><jtitle>Alzheimer's & dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bollack, Ariane</au><au>Collij, Lyduine E.</au><au>García, David Vállez</au><au>Shekari, Mahnaz</au><au>Altomare, Daniele</au><au>Payoux, Pierre</au><au>Dubois, Bruno</au><au>Grau‐Rivera, Oriol</au><au>Boada, Mercè</au><au>Marquié, Marta</au><au>Nordberg, Agneta</au><au>Walker, Zuzana</au><au>Scheltens, Philip</au><au>Schöll, Michael</au><au>Wolz, Robin</au><au>Schott, Jonathan M.</au><au>Gismondi, Rossella</au><au>Stephens, Andrew</au><au>Buckley, Christopher</au><au>Frisoni, Giovanni B.</au><au>Hanseeuw, Bernard</au><au>Visser, Pieter Jelle</au><au>Vandenberghe, Rik</au><au>Drzezga, Alexander</au><au>Yaqub, Maqsood</au><au>Boellaard, Ronald</au><au>Gispert, Juan Domingo</au><au>Markiewicz, Pawel</au><au>Cash, David M.</au><au>Farrar, Gill</au><au>Barkhof, Frederik</au><aucorp>AMYPAD consortium</aucorp><aucorp>AMYPAD Consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study</atitle><jtitle>Alzheimer's & dementia</jtitle><addtitle>Alzheimers Dement</addtitle><date>2024-05</date><risdate>2024</risdate><volume>20</volume><issue>5</issue><spage>3429</spage><epage>3441</epage><pages>3429-3441</pages><issn>1552-5260</issn><issn>1552-5279</issn><eissn>1552-5279</eissn><abstract>INTRODUCTION
To support clinical trial designs focused on early interventions, our study determined reliable early amyloid‐β (Aβ) accumulation based on Centiloids (CL) in pre‐dementia populations.
METHODS
A total of 1032 participants from the Amyloid Imaging to Prevent Alzheimer's Disease–Prognostic and Natural History Study (AMYPAD‐PNHS) and Insight46 who underwent [18F]flutemetamol, [18F]florbetaben or [18F]florbetapir amyloid‐PET were included. A normative strategy was used to define reliable accumulation by estimating the 95th percentile of longitudinal measurements in sub‐populations (NPNHS = 101/750, NInsight46 = 35/382) expected to remain stable over time. The baseline CL threshold that optimally predicts future accumulation was investigated using precision‐recall analyses. Accumulation rates were examined using linear mixed‐effect models.
RESULTS
Reliable accumulation in the PNHS was estimated to occur at >3.0 CL/year. Baseline CL of 16 [12,19] best predicted future Aβ‐accumulators. Rates of amyloid accumulation were tracer‐independent, lower for APOE ε4 non‐carriers, and for subjects with higher levels of education.
DISCUSSION
Our results support a 12–20 CL window for inclusion into early secondary prevention studies. Reliable accumulation definition warrants further investigations.</abstract><cop>United States</cop><pub>Alzheimer's Association / Wiley</pub><pmid>38574374</pmid><doi>10.1002/alz.13761</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-2617-3009</orcidid><orcidid>https://orcid.org/0000-0002-0660-0950</orcidid><orcidid>https://orcid.org/0000-0003-3543-3706</orcidid><orcidid>https://orcid.org/0000-0003-1336-6768</orcidid><orcidid>https://orcid.org/0000-0001-6263-1762</orcidid><orcidid>https://orcid.org/0000-0003-3308-3167</orcidid><orcidid>https://orcid.org/0000-0003-1905-8993</orcidid><orcidid>https://orcid.org/0000-0001-7346-8200</orcidid><orcidid>https://orcid.org/0000-0002-3114-0773</orcidid><orcidid>https://orcid.org/0000-0002-9169-7530</orcidid><orcidid>https://orcid.org/0000-0002-6155-0642</orcidid><orcidid>https://orcid.org/0000-0001-7833-616X</orcidid><orcidid>https://orcid.org/0000-0001-5052-6586</orcidid><orcidid>https://orcid.org/0000-0002-3102-6778</orcidid><orcidid>https://orcid.org/0000-0002-4730-5341</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1552-5260 |
| ispartof | Alzheimer's & dementia, 2024-05, Vol.20 (5), p.3429-3441 |
| issn | 1552-5260 1552-5279 1552-5279 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_856908 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Wiley Online Library Open Access; PubMed Central; SWEPUB Freely available online; PubMed Central Open Access |
| subjects | Aged Alzheimer Disease - diagnostic imaging Alzheimer Disease - metabolism Alzheimer's amyloid Amyloid beta-Peptides - metabolism Aniline Compounds Benzothiazoles Brain - diagnostic imaging Brain - metabolism Centiloid Clinical Medicine Female Geriatrics Geriatrik Humans Klinisk medicin Life Sciences longitudinal PET Longitudinal Studies Male Medical and Health Sciences Medicin och hälsovetenskap Middle Aged Neurosciences Neurovetenskaper Positron-Emission Tomography Prognosis quantification reliable accumulation Stilbenes |
| title | Investigating reliable amyloid accumulation in Centiloids: Results from the AMYPAD Prognostic and Natural History Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-14T04%3A39%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Investigating%20reliable%20amyloid%20accumulation%20in%20Centiloids:%20Results%20from%20the%20AMYPAD%20Prognostic%20and%20Natural%20History%20Study&rft.jtitle=Alzheimer's%20&%20dementia&rft.au=Bollack,%20Ariane&rft.aucorp=AMYPAD%20consortium&rft.date=2024-05&rft.volume=20&rft.issue=5&rft.spage=3429&rft.epage=3441&rft.pages=3429-3441&rft.issn=1552-5260&rft.eissn=1552-5279&rft_id=info:doi/10.1002/alz.13761&rft_dat=%3Cproquest_swepu%3E3034243112%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3034243112&rft_id=info:pmid/38574374&rfr_iscdi=true |