Assessing regional intracortical myelination in schizophrenia spectrum and bipolar disorders using the optimized T1w/T2w-ratio
Dysmyelination could be part of the pathophysiology of schizophrenia spectrum (SCZ) and bipolar disorders (BPD), yet few studies have examined myelination of the cerebral cortex. The ratio of T1- and T2-weighted magnetic resonance images (MRI) correlates with intracortical myelin. We investigated th...
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| Veröffentlicht in: | Psychological medicine 2024-07, Vol.54 (10), p.2369-2379 |
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| creator | Jørgensen, Kjetil Nordbø Nerland, Stener Slapø, Nora Berz Norbom, Linn B Mørch-Johnsen, Lynn Wortinger, Laura Anne Barth, Claudia Andreou, Dimitrios Maximov, Ivan I Geier, Oliver M Andreassen, Ole A Jönsson, Erik G Agartz, Ingrid |
| description | Dysmyelination could be part of the pathophysiology of schizophrenia spectrum (SCZ) and bipolar disorders (BPD), yet few studies have examined myelination of the cerebral cortex. The ratio of T1- and T2-weighted magnetic resonance images (MRI) correlates with intracortical myelin. We investigated the T1w/T2w-ratio and its age trajectories in patients and healthy controls (CTR) and explored associations with antipsychotic medication use and psychotic symptoms.
Patients with SCZ (
= 64; mean age = 30.4 years, s.d. = 9.8), BPD (
= 91; mean age 31.0 years, s.d. = 10.2), and CTR (
= 155; mean age = 31.9 years, s.d. = 9.1) who participated in the TOP study (NORMENT, University of Oslo, Norway) were clinically assessed and scanned using a General Electric 3 T MRI system. T1w/T2w-ratio images were computed using an optimized pipeline with intensity normalization and field inhomogeneity correction. Vertex-wise regression models were used to compare groups and examine group × age interactions. In regions showing significant differences, we explored associations with antipsychotic medication use and psychotic symptoms.
No main effect of diagnosis was found. However, age slopes of the T1w/T2w-ratio differed significantly between SCZ and CTR, predominantly in frontal and temporal lobe regions: Lower T1w/T2w-ratio values with higher age were found in CTR, but not in SCZ. Follow-up analyses revealed a more positive age slope in patients who were using antipsychotics and patients using higher chlorpromazine-equivalent doses.
While we found no evidence of reduced intracortical myelin in SCZ or BPD relative to CTR, different regional age trajectories in SCZ may suggest a promyelinating effect of antipsychotic medication. |
| doi_str_mv | 10.1017/S0033291724000503 |
| format | Article |
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Patients with SCZ (
= 64; mean age = 30.4 years, s.d. = 9.8), BPD (
= 91; mean age 31.0 years, s.d. = 10.2), and CTR (
= 155; mean age = 31.9 years, s.d. = 9.1) who participated in the TOP study (NORMENT, University of Oslo, Norway) were clinically assessed and scanned using a General Electric 3 T MRI system. T1w/T2w-ratio images were computed using an optimized pipeline with intensity normalization and field inhomogeneity correction. Vertex-wise regression models were used to compare groups and examine group × age interactions. In regions showing significant differences, we explored associations with antipsychotic medication use and psychotic symptoms.
No main effect of diagnosis was found. However, age slopes of the T1w/T2w-ratio differed significantly between SCZ and CTR, predominantly in frontal and temporal lobe regions: Lower T1w/T2w-ratio values with higher age were found in CTR, but not in SCZ. Follow-up analyses revealed a more positive age slope in patients who were using antipsychotics and patients using higher chlorpromazine-equivalent doses.
While we found no evidence of reduced intracortical myelin in SCZ or BPD relative to CTR, different regional age trajectories in SCZ may suggest a promyelinating effect of antipsychotic medication.</description><identifier>ISSN: 0033-2917</identifier><identifier>ISSN: 1469-8978</identifier><identifier>EISSN: 1469-8978</identifier><identifier>DOI: 10.1017/S0033291724000503</identifier><identifier>PMID: 38563302</identifier><language>eng</language><publisher>England: Cambridge University Press</publisher><subject>Adult ; Age ; Age differences ; Antipsychotic Agents - pharmacology ; Antipsychotic Agents - therapeutic use ; Antipsychotics ; Bipolar disorder ; Bipolar Disorder - diagnostic imaging ; Bipolar Disorder - drug therapy ; Bipolar Disorder - physiopathology ; Brain research ; Cerebral cortex ; Cerebral Cortex - diagnostic imaging ; Cerebral Cortex - drug effects ; Cerebral Cortex - pathology ; Cerebral Cortex - physiopathology ; Chlorpromazine ; Cortex ; Dosage ; Drugs ; Entorhinal cortex ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Medical diagnosis ; Mental disorders ; Middle Aged ; Myelin Sheath - pathology ; Myelination ; Normalization ; Pathophysiology ; Patients ; Psychosis ; Psychotic symptoms ; Psychotropic drugs ; Regions ; Regression analysis ; Schizophrenia ; Schizophrenia - diagnostic imaging ; Schizophrenia - drug therapy ; Schizophrenia - physiopathology ; Temporal lobe ; Temporal lobes ; Young Adult</subject><ispartof>Psychological medicine, 2024-07, Vol.54 (10), p.2369-2379</ispartof><rights>Copyright © The Author(s), 2024. Published by Cambridge University Press. This work is licensed under the Creative Commons Attribution – Non-Commercial – Share Alike License This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http://creativecommons.org/licenses/by-nc-sa/4.0), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is used to distribute the re-used or adapted article and the original article is properly cited. The written permission of Cambridge University Press must be obtained prior to any commercial use. (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c387t-d991d954d1e31c6d45a1e645913655c42b9a32d6fc121b47c3a557ff8148b8923</cites><orcidid>0000-0002-9839-5391 ; 0000-0002-5751-4809 ; 0000-0001-8368-6332 ; 0000-0003-2721-3172 ; 0000-0001-6544-0945 ; 0000-0003-4735-3383 ; 0000-0001-7489-2724 ; 0000-0001-9360-8610 ; 0000-0001-8771-8856 ; 0000-0002-0185-3713 ; 0000-0003-3919-7579 ; 0000-0001-6319-6774 ; 0000-0002-4461-3568</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,12825,26544,27901,27902,30976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38563302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:155376410$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Jørgensen, Kjetil Nordbø</creatorcontrib><creatorcontrib>Nerland, Stener</creatorcontrib><creatorcontrib>Slapø, Nora Berz</creatorcontrib><creatorcontrib>Norbom, Linn B</creatorcontrib><creatorcontrib>Mørch-Johnsen, Lynn</creatorcontrib><creatorcontrib>Wortinger, Laura Anne</creatorcontrib><creatorcontrib>Barth, Claudia</creatorcontrib><creatorcontrib>Andreou, Dimitrios</creatorcontrib><creatorcontrib>Maximov, Ivan I</creatorcontrib><creatorcontrib>Geier, Oliver M</creatorcontrib><creatorcontrib>Andreassen, Ole A</creatorcontrib><creatorcontrib>Jönsson, Erik G</creatorcontrib><creatorcontrib>Agartz, Ingrid</creatorcontrib><title>Assessing regional intracortical myelination in schizophrenia spectrum and bipolar disorders using the optimized T1w/T2w-ratio</title><title>Psychological medicine</title><addtitle>Psychol Med</addtitle><description>Dysmyelination could be part of the pathophysiology of schizophrenia spectrum (SCZ) and bipolar disorders (BPD), yet few studies have examined myelination of the cerebral cortex. The ratio of T1- and T2-weighted magnetic resonance images (MRI) correlates with intracortical myelin. We investigated the T1w/T2w-ratio and its age trajectories in patients and healthy controls (CTR) and explored associations with antipsychotic medication use and psychotic symptoms.
Patients with SCZ (
= 64; mean age = 30.4 years, s.d. = 9.8), BPD (
= 91; mean age 31.0 years, s.d. = 10.2), and CTR (
= 155; mean age = 31.9 years, s.d. = 9.1) who participated in the TOP study (NORMENT, University of Oslo, Norway) were clinically assessed and scanned using a General Electric 3 T MRI system. T1w/T2w-ratio images were computed using an optimized pipeline with intensity normalization and field inhomogeneity correction. Vertex-wise regression models were used to compare groups and examine group × age interactions. In regions showing significant differences, we explored associations with antipsychotic medication use and psychotic symptoms.
No main effect of diagnosis was found. However, age slopes of the T1w/T2w-ratio differed significantly between SCZ and CTR, predominantly in frontal and temporal lobe regions: Lower T1w/T2w-ratio values with higher age were found in CTR, but not in SCZ. Follow-up analyses revealed a more positive age slope in patients who were using antipsychotics and patients using higher chlorpromazine-equivalent doses.
While we found no evidence of reduced intracortical myelin in SCZ or BPD relative to CTR, different regional age trajectories in SCZ may suggest a promyelinating effect of antipsychotic medication.</description><subject>Adult</subject><subject>Age</subject><subject>Age differences</subject><subject>Antipsychotic Agents - pharmacology</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Antipsychotics</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - diagnostic imaging</subject><subject>Bipolar Disorder - drug therapy</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Brain research</subject><subject>Cerebral cortex</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cerebral Cortex - drug effects</subject><subject>Cerebral Cortex - pathology</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Chlorpromazine</subject><subject>Cortex</subject><subject>Dosage</subject><subject>Drugs</subject><subject>Entorhinal cortex</subject><subject>Female</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Mental disorders</subject><subject>Middle Aged</subject><subject>Myelin Sheath - pathology</subject><subject>Myelination</subject><subject>Normalization</subject><subject>Pathophysiology</subject><subject>Patients</subject><subject>Psychosis</subject><subject>Psychotic symptoms</subject><subject>Psychotropic drugs</subject><subject>Regions</subject><subject>Regression analysis</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnostic imaging</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenia - physiopathology</subject><subject>Temporal lobe</subject><subject>Temporal lobes</subject><subject>Young Adult</subject><issn>0033-2917</issn><issn>1469-8978</issn><issn>1469-8978</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>3HK</sourceid><sourceid>D8T</sourceid><recordid>eNplkUtv1DAUhS1ERYfCD2CDLLFhE-rrR2Ivq6oUpEosOqwtx3Y6Lkkc7ESjdsFvx-lMu4CVH-c7x9Y9CH0A8gUINOe3hDBGFTSUE0IEYa_QBnitKqka-RptVrla9VP0Nud7QoABp2_QKZOiZozQDfpzkbPPOYx3OPm7EEfT4zDOydiY5mDLaXjwfRjNXLSi4Gx34TFOu-THYHCevJ3TMmAzOtyGKfYmYRdyTM6njJen4HnncZzmMIRH7_AW9udbuq_SGvkOnXSmz_79cT1DP79ebS-_VTc_rr9fXtxUlslmrpxS4JTgDjwDWzsuDPiaCwWsFsJy2irDqKs7CxRa3lhmhGi6TgKXrVSUnaHqkJv3flpaPaUwmPSgown6ePWr7LyWxSdE4fGBtynkOYx6jMloIFJQDWXEzYp8PiBTir8Xn2c9hGx935vRxyVrRhgAE6ThBf30D3ofl1RGXSignNEaKCkUPL8Zc06-e_klEL32rf_ru3g-HpOXdvDuxfFcMPsLj-ylGA</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Jørgensen, Kjetil Nordbø</creator><creator>Nerland, Stener</creator><creator>Slapø, Nora Berz</creator><creator>Norbom, Linn B</creator><creator>Mørch-Johnsen, Lynn</creator><creator>Wortinger, Laura Anne</creator><creator>Barth, Claudia</creator><creator>Andreou, Dimitrios</creator><creator>Maximov, Ivan I</creator><creator>Geier, Oliver M</creator><creator>Andreassen, Ole A</creator><creator>Jönsson, Erik G</creator><creator>Agartz, Ingrid</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7QP</scope><scope>7QR</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2S</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>3HK</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-9839-5391</orcidid><orcidid>https://orcid.org/0000-0002-5751-4809</orcidid><orcidid>https://orcid.org/0000-0001-8368-6332</orcidid><orcidid>https://orcid.org/0000-0003-2721-3172</orcidid><orcidid>https://orcid.org/0000-0001-6544-0945</orcidid><orcidid>https://orcid.org/0000-0003-4735-3383</orcidid><orcidid>https://orcid.org/0000-0001-7489-2724</orcidid><orcidid>https://orcid.org/0000-0001-9360-8610</orcidid><orcidid>https://orcid.org/0000-0001-8771-8856</orcidid><orcidid>https://orcid.org/0000-0002-0185-3713</orcidid><orcidid>https://orcid.org/0000-0003-3919-7579</orcidid><orcidid>https://orcid.org/0000-0001-6319-6774</orcidid><orcidid>https://orcid.org/0000-0002-4461-3568</orcidid></search><sort><creationdate>20240701</creationdate><title>Assessing regional intracortical myelination in schizophrenia spectrum and bipolar disorders using the optimized T1w/T2w-ratio</title><author>Jørgensen, Kjetil Nordbø ; Nerland, Stener ; Slapø, Nora Berz ; Norbom, Linn B ; Mørch-Johnsen, Lynn ; Wortinger, Laura Anne ; Barth, Claudia ; Andreou, Dimitrios ; Maximov, Ivan I ; Geier, Oliver M ; Andreassen, Ole A ; Jönsson, Erik G ; Agartz, Ingrid</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-d991d954d1e31c6d45a1e645913655c42b9a32d6fc121b47c3a557ff8148b8923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age differences</topic><topic>Antipsychotic Agents - 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Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Psychological medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jørgensen, Kjetil Nordbø</au><au>Nerland, Stener</au><au>Slapø, Nora Berz</au><au>Norbom, Linn B</au><au>Mørch-Johnsen, Lynn</au><au>Wortinger, Laura Anne</au><au>Barth, Claudia</au><au>Andreou, Dimitrios</au><au>Maximov, Ivan I</au><au>Geier, Oliver M</au><au>Andreassen, Ole A</au><au>Jönsson, Erik G</au><au>Agartz, Ingrid</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing regional intracortical myelination in schizophrenia spectrum and bipolar disorders using the optimized T1w/T2w-ratio</atitle><jtitle>Psychological medicine</jtitle><addtitle>Psychol Med</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>54</volume><issue>10</issue><spage>2369</spage><epage>2379</epage><pages>2369-2379</pages><issn>0033-2917</issn><issn>1469-8978</issn><eissn>1469-8978</eissn><abstract>Dysmyelination could be part of the pathophysiology of schizophrenia spectrum (SCZ) and bipolar disorders (BPD), yet few studies have examined myelination of the cerebral cortex. The ratio of T1- and T2-weighted magnetic resonance images (MRI) correlates with intracortical myelin. We investigated the T1w/T2w-ratio and its age trajectories in patients and healthy controls (CTR) and explored associations with antipsychotic medication use and psychotic symptoms.
Patients with SCZ (
= 64; mean age = 30.4 years, s.d. = 9.8), BPD (
= 91; mean age 31.0 years, s.d. = 10.2), and CTR (
= 155; mean age = 31.9 years, s.d. = 9.1) who participated in the TOP study (NORMENT, University of Oslo, Norway) were clinically assessed and scanned using a General Electric 3 T MRI system. T1w/T2w-ratio images were computed using an optimized pipeline with intensity normalization and field inhomogeneity correction. Vertex-wise regression models were used to compare groups and examine group × age interactions. In regions showing significant differences, we explored associations with antipsychotic medication use and psychotic symptoms.
No main effect of diagnosis was found. However, age slopes of the T1w/T2w-ratio differed significantly between SCZ and CTR, predominantly in frontal and temporal lobe regions: Lower T1w/T2w-ratio values with higher age were found in CTR, but not in SCZ. Follow-up analyses revealed a more positive age slope in patients who were using antipsychotics and patients using higher chlorpromazine-equivalent doses.
While we found no evidence of reduced intracortical myelin in SCZ or BPD relative to CTR, different regional age trajectories in SCZ may suggest a promyelinating effect of antipsychotic medication.</abstract><cop>England</cop><pub>Cambridge University Press</pub><pmid>38563302</pmid><doi>10.1017/S0033291724000503</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-9839-5391</orcidid><orcidid>https://orcid.org/0000-0002-5751-4809</orcidid><orcidid>https://orcid.org/0000-0001-8368-6332</orcidid><orcidid>https://orcid.org/0000-0003-2721-3172</orcidid><orcidid>https://orcid.org/0000-0001-6544-0945</orcidid><orcidid>https://orcid.org/0000-0003-4735-3383</orcidid><orcidid>https://orcid.org/0000-0001-7489-2724</orcidid><orcidid>https://orcid.org/0000-0001-9360-8610</orcidid><orcidid>https://orcid.org/0000-0001-8771-8856</orcidid><orcidid>https://orcid.org/0000-0002-0185-3713</orcidid><orcidid>https://orcid.org/0000-0003-3919-7579</orcidid><orcidid>https://orcid.org/0000-0001-6319-6774</orcidid><orcidid>https://orcid.org/0000-0002-4461-3568</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0033-2917 |
| ispartof | Psychological medicine, 2024-07, Vol.54 (10), p.2369-2379 |
| issn | 0033-2917 1469-8978 1469-8978 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_855755 |
| source | Applied Social Sciences Index & Abstracts (ASSIA); MEDLINE; NORA - Norwegian Open Research Archives; Cambridge Journals; SWEPUB Freely available online |
| subjects | Adult Age Age differences Antipsychotic Agents - pharmacology Antipsychotic Agents - therapeutic use Antipsychotics Bipolar disorder Bipolar Disorder - diagnostic imaging Bipolar Disorder - drug therapy Bipolar Disorder - physiopathology Brain research Cerebral cortex Cerebral Cortex - diagnostic imaging Cerebral Cortex - drug effects Cerebral Cortex - pathology Cerebral Cortex - physiopathology Chlorpromazine Cortex Dosage Drugs Entorhinal cortex Female Humans Magnetic Resonance Imaging Male Medical diagnosis Mental disorders Middle Aged Myelin Sheath - pathology Myelination Normalization Pathophysiology Patients Psychosis Psychotic symptoms Psychotropic drugs Regions Regression analysis Schizophrenia Schizophrenia - diagnostic imaging Schizophrenia - drug therapy Schizophrenia - physiopathology Temporal lobe Temporal lobes Young Adult |
| title | Assessing regional intracortical myelination in schizophrenia spectrum and bipolar disorders using the optimized T1w/T2w-ratio |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T12%3A26%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessing%20regional%20intracortical%20myelination%20in%20schizophrenia%20spectrum%20and%20bipolar%20disorders%20using%20the%20optimized%20T1w/T2w-ratio&rft.jtitle=Psychological%20medicine&rft.au=J%C3%B8rgensen,%20Kjetil%20Nordb%C3%B8&rft.date=2024-07-01&rft.volume=54&rft.issue=10&rft.spage=2369&rft.epage=2379&rft.pages=2369-2379&rft.issn=0033-2917&rft.eissn=1469-8978&rft_id=info:doi/10.1017/S0033291724000503&rft_dat=%3Cproquest_swepu%3E3124326120%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3124326120&rft_id=info:pmid/38563302&rfr_iscdi=true |