Fixel-Based Analysis Reveals Tau-Related White Matter Changes in Early Stages of Alzheimer's Disease

Several studies have shown white matter (WM) abnormalities in Alzheimer's disease (AD) using diffusion tensor imaging (DTI). Nonetheless, robust characterization of WM changes has been challenging due to the methodological limitations of DTI. We applied fixel-based analyses (FBA) to examine mic...

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Veröffentlicht in:	The Journal of neuroscience 2024-05, Vol.44 (18), p.e0538232024
Hauptverfasser:	Ahmadi, Khazar, Pereira, Joana B, van Westen, Danielle, Pasternak, Ofer, Zhang, Fan, Nilsson, Markus, Stomrud, Erik, Spotorno, Nicola, Hansson, Oskar
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Aged Aged, 80 and over Aggregation Alzheimer Disease - diagnostic imaging Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Cingulum Clinical Medicine Cognition Cognitive ability Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - pathology Degeneration Diffusion diffusion tensor imaging Diffusion Tensor Imaging - methods Female fixel-based analysis Humans Klinisk medicin Kurtosis Magnetic resonance imaging Male Medical and Health Sciences Medical imaging Medicin och hälsovetenskap memory Middle Aged Neurodegenerative diseases Pathology Positron emission Radiologi och bildbehandling Radiology, Nuclear Medicine and Medical Imaging Substantia alba Tau protein tau Proteins - metabolism Tensors Thalamus white matter White Matter - diagnostic imaging White Matter - pathology β-Amyloid
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