Allometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis
Background Traditional body-shape indices such as Waist Circumference (WC), Hip Circumference (HC), and Waist-to-Hip Ratio (WHR) are associated with colorectal cancer (CRC) risk, but are correlated with Body Mass Index (BMI), and adjustment for BMI introduces a strong correlation with height. Thus,...
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| creator | Rontogianni, Marina O. Bouras, Emmanouil Aglago, Elom Kouassivi Freisling, Heinz Murphy, Neil Cotterchio, Michelle Hampe, Jochen Lindblom, Annika Pai, Rish K. Pharoah, Paul D. P. Phipps, Amanda I. van Duijnhoven, Franzel J. B. Visvanathan, Kala van Guelpen, Bethany Li, Christopher I. Brenner, Hermann Pellatt, Andrew J. Ogino, Shuji Gunter, Marc J. Peters, Ulrike Christakoudi, Sofia Tsilidis, Konstantinos K. |
| description | Background
Traditional body-shape indices such as Waist Circumference (WC), Hip Circumference (HC), and Waist-to-Hip Ratio (WHR) are associated with colorectal cancer (CRC) risk, but are correlated with Body Mass Index (BMI), and adjustment for BMI introduces a strong correlation with height. Thus, new allometric indices have been developed, namely A Body Shape Index (ABSI), Hip Index (HI), and Waist-to-Hip Index (WHI), which are uncorrelated with weight and height; these have also been associated with CRC risk in observational studies, but information from Mendelian randomization (MR) studies is missing.
Methods
We used two-sample MR to examine potential causal cancer site- and sex-specific associations of the genetically-predicted allometric body-shape indices with CRC risk, and compared them with BMI-adjusted traditional body-shape indices, and BMI. Data were obtained from UK Biobank and the GIANT consortium, and from GECCO, CORECT and CCFR consortia.
Results
WHI was positively associated with CRC in men (OR per SD: 1.20, 95% CI: 1.03–1.39) and in women (1.15, 1.06–1.24), and similarly for colon and rectal cancer. ABSI was positively associated with colon and rectal cancer in men (1.27, 1.03–1.57; and 1.40, 1.10–1.77, respectively), and with colon cancer in women (1.20, 1.07–1.35). There was little evidence for association between HI and colon or rectal cancer. The BMI-adjusted WHR and HC showed similar associations to WHI and HI, whereas WC showed similar associations to ABSI only in women.
Conclusions
This large MR study provides strong evidence for a potential causal positive association of the allometric indices ABSI and WHI with CRC in both sexes, thus establishing the association between abdominal fat and CRC without the limitations of the traditional waist size indices and independently of BMI. Among the BMI-adjusted traditional indices, WHR and HC provided equivalent associations with WHI and HI, while differences were observed between WC and ABSI. |
| doi_str_mv | 10.1038/s41366-024-01479-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_846071</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3048257459</sourcerecordid><originalsourceid>FETCH-LOGICAL-c551t-b049327fe9bc15576641ab85355f57d16f864eb4e0db4b06fc94b8675f4529f43</originalsourceid><addsrcrecordid>eNp9kktv1DAUhS0EoqXwB1ggS2y6CdiOn2zQqDylIjbA1nKcm6lbJx7spGj49XiYoVAWXfnK9zvn2lcHoaeUvKCk1S8Lp62UDWG8IZQr08h76LgWshHcqPvomLRENURIcYQelXJJCBGCsIfoqNXMqNo9RnkVYxphzsHja8hlKXjOrg9zSJOLuEv9tikXbgM4TH3wULCbepxDucJpwD7FlMHPlfRu8pBfYYc_wdRDDG7CubJpDD_dzq0KXdyWUB6jB4OLBZ4czhP09d3bL2cfmvPP7z-erc4bLwSdm45w0zI1gOk8FUJJyanrtGiFGITqqRy05NBxIH3HOyIHb3inpRIDF8wMvD1Bzd63_IDN0tlNDqPLW5tcsIerq1qB1VwSRe_k34RvK5vy2i7jYhkjWu_8X-_5Co_Qe5jq5uIt2e3OFC7sOl1bSonQLd1NPD045PR9gTLbMRQPMboJ0lIsM4zS-nfDKvr8P_QyLblutNiWcM2E4sJUiu0pn1MpGYab11Bid5mx-8zYmhn7OzNWVtGzf_9xI_kTkgq0h8XU1rSG_Hf2Hba_APCnz0A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3048257459</pqid></control><display><type>article</type><title>Allometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Nature Journals Online</source><source>SWEPUB Freely available online</source><creator>Rontogianni, Marina O. ; Bouras, Emmanouil ; Aglago, Elom Kouassivi ; Freisling, Heinz ; Murphy, Neil ; Cotterchio, Michelle ; Hampe, Jochen ; Lindblom, Annika ; Pai, Rish K. ; Pharoah, Paul D. P. ; Phipps, Amanda I. ; van Duijnhoven, Franzel J. B. ; Visvanathan, Kala ; van Guelpen, Bethany ; Li, Christopher I. ; Brenner, Hermann ; Pellatt, Andrew J. ; Ogino, Shuji ; Gunter, Marc J. ; Peters, Ulrike ; Christakoudi, Sofia ; Tsilidis, Konstantinos K.</creator><creatorcontrib>Rontogianni, Marina O. ; Bouras, Emmanouil ; Aglago, Elom Kouassivi ; Freisling, Heinz ; Murphy, Neil ; Cotterchio, Michelle ; Hampe, Jochen ; Lindblom, Annika ; Pai, Rish K. ; Pharoah, Paul D. P. ; Phipps, Amanda I. ; van Duijnhoven, Franzel J. B. ; Visvanathan, Kala ; van Guelpen, Bethany ; Li, Christopher I. ; Brenner, Hermann ; Pellatt, Andrew J. ; Ogino, Shuji ; Gunter, Marc J. ; Peters, Ulrike ; Christakoudi, Sofia ; Tsilidis, Konstantinos K.</creatorcontrib><description>Background
Traditional body-shape indices such as Waist Circumference (WC), Hip Circumference (HC), and Waist-to-Hip Ratio (WHR) are associated with colorectal cancer (CRC) risk, but are correlated with Body Mass Index (BMI), and adjustment for BMI introduces a strong correlation with height. Thus, new allometric indices have been developed, namely A Body Shape Index (ABSI), Hip Index (HI), and Waist-to-Hip Index (WHI), which are uncorrelated with weight and height; these have also been associated with CRC risk in observational studies, but information from Mendelian randomization (MR) studies is missing.
Methods
We used two-sample MR to examine potential causal cancer site- and sex-specific associations of the genetically-predicted allometric body-shape indices with CRC risk, and compared them with BMI-adjusted traditional body-shape indices, and BMI. Data were obtained from UK Biobank and the GIANT consortium, and from GECCO, CORECT and CCFR consortia.
Results
WHI was positively associated with CRC in men (OR per SD: 1.20, 95% CI: 1.03–1.39) and in women (1.15, 1.06–1.24), and similarly for colon and rectal cancer. ABSI was positively associated with colon and rectal cancer in men (1.27, 1.03–1.57; and 1.40, 1.10–1.77, respectively), and with colon cancer in women (1.20, 1.07–1.35). There was little evidence for association between HI and colon or rectal cancer. The BMI-adjusted WHR and HC showed similar associations to WHI and HI, whereas WC showed similar associations to ABSI only in women.
Conclusions
This large MR study provides strong evidence for a potential causal positive association of the allometric indices ABSI and WHI with CRC in both sexes, thus establishing the association between abdominal fat and CRC without the limitations of the traditional waist size indices and independently of BMI. Among the BMI-adjusted traditional indices, WHR and HC provided equivalent associations with WHI and HI, while differences were observed between WC and ABSI.</description><identifier>ISSN: 0307-0565</identifier><identifier>ISSN: 1476-5497</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/s41366-024-01479-6</identifier><identifier>PMID: 38297030</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/499 ; 692/699/67 ; Body Mass Index ; Body measurements ; Body size ; Colon ; Colon cancer ; Colorectal cancer ; Colorectal carcinoma ; Colorectal Neoplasms - epidemiology ; Colorectal Neoplasms - genetics ; Consortia ; Epidemiology ; Female ; Health Promotion and Disease Prevention ; Humans ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Men ; Mendelian Randomization Analysis - methods ; Metabolic Diseases ; Observational studies ; Public Health ; Randomization ; Rectum ; Risk ; Risk Factors ; Waist Circumference ; Waist-Hip Ratio ; Women</subject><ispartof>INTERNATIONAL JOURNAL OF OBESITY, 2024-05, Vol.48 (5), p.709-716</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>The Author(s) 2024. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c551t-b049327fe9bc15576641ab85355f57d16f864eb4e0db4b06fc94b8675f4529f43</citedby><cites>FETCH-LOGICAL-c551t-b049327fe9bc15576641ab85355f57d16f864eb4e0db4b06fc94b8675f4529f43</cites><orcidid>0000-0002-2421-6127 ; 0000-0001-8494-732X ; 0000-0002-8452-8472 ; 0000-0002-6129-1572 ; 0000-0002-0127-9790</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41366-024-01479-6$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41366-024-01479-6$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38297030$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-220884$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:154890836$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Rontogianni, Marina O.</creatorcontrib><creatorcontrib>Bouras, Emmanouil</creatorcontrib><creatorcontrib>Aglago, Elom Kouassivi</creatorcontrib><creatorcontrib>Freisling, Heinz</creatorcontrib><creatorcontrib>Murphy, Neil</creatorcontrib><creatorcontrib>Cotterchio, Michelle</creatorcontrib><creatorcontrib>Hampe, Jochen</creatorcontrib><creatorcontrib>Lindblom, Annika</creatorcontrib><creatorcontrib>Pai, Rish K.</creatorcontrib><creatorcontrib>Pharoah, Paul D. P.</creatorcontrib><creatorcontrib>Phipps, Amanda I.</creatorcontrib><creatorcontrib>van Duijnhoven, Franzel J. B.</creatorcontrib><creatorcontrib>Visvanathan, Kala</creatorcontrib><creatorcontrib>van Guelpen, Bethany</creatorcontrib><creatorcontrib>Li, Christopher I.</creatorcontrib><creatorcontrib>Brenner, Hermann</creatorcontrib><creatorcontrib>Pellatt, Andrew J.</creatorcontrib><creatorcontrib>Ogino, Shuji</creatorcontrib><creatorcontrib>Gunter, Marc J.</creatorcontrib><creatorcontrib>Peters, Ulrike</creatorcontrib><creatorcontrib>Christakoudi, Sofia</creatorcontrib><creatorcontrib>Tsilidis, Konstantinos K.</creatorcontrib><title>Allometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis</title><title>INTERNATIONAL JOURNAL OF OBESITY</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background
Traditional body-shape indices such as Waist Circumference (WC), Hip Circumference (HC), and Waist-to-Hip Ratio (WHR) are associated with colorectal cancer (CRC) risk, but are correlated with Body Mass Index (BMI), and adjustment for BMI introduces a strong correlation with height. Thus, new allometric indices have been developed, namely A Body Shape Index (ABSI), Hip Index (HI), and Waist-to-Hip Index (WHI), which are uncorrelated with weight and height; these have also been associated with CRC risk in observational studies, but information from Mendelian randomization (MR) studies is missing.
Methods
We used two-sample MR to examine potential causal cancer site- and sex-specific associations of the genetically-predicted allometric body-shape indices with CRC risk, and compared them with BMI-adjusted traditional body-shape indices, and BMI. Data were obtained from UK Biobank and the GIANT consortium, and from GECCO, CORECT and CCFR consortia.
Results
WHI was positively associated with CRC in men (OR per SD: 1.20, 95% CI: 1.03–1.39) and in women (1.15, 1.06–1.24), and similarly for colon and rectal cancer. ABSI was positively associated with colon and rectal cancer in men (1.27, 1.03–1.57; and 1.40, 1.10–1.77, respectively), and with colon cancer in women (1.20, 1.07–1.35). There was little evidence for association between HI and colon or rectal cancer. The BMI-adjusted WHR and HC showed similar associations to WHI and HI, whereas WC showed similar associations to ABSI only in women.
Conclusions
This large MR study provides strong evidence for a potential causal positive association of the allometric indices ABSI and WHI with CRC in both sexes, thus establishing the association between abdominal fat and CRC without the limitations of the traditional waist size indices and independently of BMI. Among the BMI-adjusted traditional indices, WHR and HC provided equivalent associations with WHI and HI, while differences were observed between WC and ABSI.</description><subject>692/499</subject><subject>692/699/67</subject><subject>Body Mass Index</subject><subject>Body measurements</subject><subject>Body size</subject><subject>Colon</subject><subject>Colon cancer</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Colorectal Neoplasms - epidemiology</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Consortia</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health Promotion and Disease Prevention</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Men</subject><subject>Mendelian Randomization Analysis - methods</subject><subject>Metabolic Diseases</subject><subject>Observational studies</subject><subject>Public Health</subject><subject>Randomization</subject><subject>Rectum</subject><subject>Risk</subject><subject>Risk Factors</subject><subject>Waist Circumference</subject><subject>Waist-Hip Ratio</subject><subject>Women</subject><issn>0307-0565</issn><issn>1476-5497</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp9kktv1DAUhS0EoqXwB1ggS2y6CdiOn2zQqDylIjbA1nKcm6lbJx7spGj49XiYoVAWXfnK9zvn2lcHoaeUvKCk1S8Lp62UDWG8IZQr08h76LgWshHcqPvomLRENURIcYQelXJJCBGCsIfoqNXMqNo9RnkVYxphzsHja8hlKXjOrg9zSJOLuEv9tikXbgM4TH3wULCbepxDucJpwD7FlMHPlfRu8pBfYYc_wdRDDG7CubJpDD_dzq0KXdyWUB6jB4OLBZ4czhP09d3bL2cfmvPP7z-erc4bLwSdm45w0zI1gOk8FUJJyanrtGiFGITqqRy05NBxIH3HOyIHb3inpRIDF8wMvD1Bzd63_IDN0tlNDqPLW5tcsIerq1qB1VwSRe_k34RvK5vy2i7jYhkjWu_8X-_5Co_Qe5jq5uIt2e3OFC7sOl1bSonQLd1NPD045PR9gTLbMRQPMboJ0lIsM4zS-nfDKvr8P_QyLblutNiWcM2E4sJUiu0pn1MpGYab11Bid5mx-8zYmhn7OzNWVtGzf_9xI_kTkgq0h8XU1rSG_Hf2Hba_APCnz0A</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Rontogianni, Marina O.</creator><creator>Bouras, Emmanouil</creator><creator>Aglago, Elom Kouassivi</creator><creator>Freisling, Heinz</creator><creator>Murphy, Neil</creator><creator>Cotterchio, Michelle</creator><creator>Hampe, Jochen</creator><creator>Lindblom, Annika</creator><creator>Pai, Rish K.</creator><creator>Pharoah, Paul D. P.</creator><creator>Phipps, Amanda I.</creator><creator>van Duijnhoven, Franzel J. B.</creator><creator>Visvanathan, Kala</creator><creator>van Guelpen, Bethany</creator><creator>Li, Christopher I.</creator><creator>Brenner, Hermann</creator><creator>Pellatt, Andrew J.</creator><creator>Ogino, Shuji</creator><creator>Gunter, Marc J.</creator><creator>Peters, Ulrike</creator><creator>Christakoudi, Sofia</creator><creator>Tsilidis, Konstantinos K.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><scope>ADHXS</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>D93</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-2421-6127</orcidid><orcidid>https://orcid.org/0000-0001-8494-732X</orcidid><orcidid>https://orcid.org/0000-0002-8452-8472</orcidid><orcidid>https://orcid.org/0000-0002-6129-1572</orcidid><orcidid>https://orcid.org/0000-0002-0127-9790</orcidid></search><sort><creationdate>20240501</creationdate><title>Allometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis</title><author>Rontogianni, Marina O. ; Bouras, Emmanouil ; Aglago, Elom Kouassivi ; Freisling, Heinz ; Murphy, Neil ; Cotterchio, Michelle ; Hampe, Jochen ; Lindblom, Annika ; Pai, Rish K. ; Pharoah, Paul D. P. ; Phipps, Amanda I. ; van Duijnhoven, Franzel J. B. ; Visvanathan, Kala ; van Guelpen, Bethany ; Li, Christopher I. ; Brenner, Hermann ; Pellatt, Andrew J. ; Ogino, Shuji ; Gunter, Marc J. ; Peters, Ulrike ; Christakoudi, Sofia ; Tsilidis, Konstantinos K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c551t-b049327fe9bc15576641ab85355f57d16f864eb4e0db4b06fc94b8675f4529f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>692/499</topic><topic>692/699/67</topic><topic>Body Mass Index</topic><topic>Body measurements</topic><topic>Body size</topic><topic>Colon</topic><topic>Colon cancer</topic><topic>Colorectal cancer</topic><topic>Colorectal carcinoma</topic><topic>Colorectal Neoplasms - epidemiology</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Consortia</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Health Promotion and Disease Prevention</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Men</topic><topic>Mendelian Randomization Analysis - methods</topic><topic>Metabolic Diseases</topic><topic>Observational studies</topic><topic>Public Health</topic><topic>Randomization</topic><topic>Rectum</topic><topic>Risk</topic><topic>Risk Factors</topic><topic>Waist Circumference</topic><topic>Waist-Hip Ratio</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rontogianni, Marina O.</creatorcontrib><creatorcontrib>Bouras, Emmanouil</creatorcontrib><creatorcontrib>Aglago, Elom Kouassivi</creatorcontrib><creatorcontrib>Freisling, Heinz</creatorcontrib><creatorcontrib>Murphy, Neil</creatorcontrib><creatorcontrib>Cotterchio, Michelle</creatorcontrib><creatorcontrib>Hampe, Jochen</creatorcontrib><creatorcontrib>Lindblom, Annika</creatorcontrib><creatorcontrib>Pai, Rish K.</creatorcontrib><creatorcontrib>Pharoah, Paul D. P.</creatorcontrib><creatorcontrib>Phipps, Amanda I.</creatorcontrib><creatorcontrib>van Duijnhoven, Franzel J. B.</creatorcontrib><creatorcontrib>Visvanathan, Kala</creatorcontrib><creatorcontrib>van Guelpen, Bethany</creatorcontrib><creatorcontrib>Li, Christopher I.</creatorcontrib><creatorcontrib>Brenner, Hermann</creatorcontrib><creatorcontrib>Pellatt, Andrew J.</creatorcontrib><creatorcontrib>Ogino, Shuji</creatorcontrib><creatorcontrib>Gunter, Marc J.</creatorcontrib><creatorcontrib>Peters, Ulrike</creatorcontrib><creatorcontrib>Christakoudi, Sofia</creatorcontrib><creatorcontrib>Tsilidis, Konstantinos K.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Umeå universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Umeå universitet</collection><collection>SwePub Articles full text</collection><jtitle>INTERNATIONAL JOURNAL OF OBESITY</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rontogianni, Marina O.</au><au>Bouras, Emmanouil</au><au>Aglago, Elom Kouassivi</au><au>Freisling, Heinz</au><au>Murphy, Neil</au><au>Cotterchio, Michelle</au><au>Hampe, Jochen</au><au>Lindblom, Annika</au><au>Pai, Rish K.</au><au>Pharoah, Paul D. P.</au><au>Phipps, Amanda I.</au><au>van Duijnhoven, Franzel J. B.</au><au>Visvanathan, Kala</au><au>van Guelpen, Bethany</au><au>Li, Christopher I.</au><au>Brenner, Hermann</au><au>Pellatt, Andrew J.</au><au>Ogino, Shuji</au><au>Gunter, Marc J.</au><au>Peters, Ulrike</au><au>Christakoudi, Sofia</au><au>Tsilidis, Konstantinos K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Allometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis</atitle><jtitle>INTERNATIONAL JOURNAL OF OBESITY</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>48</volume><issue>5</issue><spage>709</spage><epage>716</epage><pages>709-716</pages><issn>0307-0565</issn><issn>1476-5497</issn><eissn>1476-5497</eissn><abstract>Background
Traditional body-shape indices such as Waist Circumference (WC), Hip Circumference (HC), and Waist-to-Hip Ratio (WHR) are associated with colorectal cancer (CRC) risk, but are correlated with Body Mass Index (BMI), and adjustment for BMI introduces a strong correlation with height. Thus, new allometric indices have been developed, namely A Body Shape Index (ABSI), Hip Index (HI), and Waist-to-Hip Index (WHI), which are uncorrelated with weight and height; these have also been associated with CRC risk in observational studies, but information from Mendelian randomization (MR) studies is missing.
Methods
We used two-sample MR to examine potential causal cancer site- and sex-specific associations of the genetically-predicted allometric body-shape indices with CRC risk, and compared them with BMI-adjusted traditional body-shape indices, and BMI. Data were obtained from UK Biobank and the GIANT consortium, and from GECCO, CORECT and CCFR consortia.
Results
WHI was positively associated with CRC in men (OR per SD: 1.20, 95% CI: 1.03–1.39) and in women (1.15, 1.06–1.24), and similarly for colon and rectal cancer. ABSI was positively associated with colon and rectal cancer in men (1.27, 1.03–1.57; and 1.40, 1.10–1.77, respectively), and with colon cancer in women (1.20, 1.07–1.35). There was little evidence for association between HI and colon or rectal cancer. The BMI-adjusted WHR and HC showed similar associations to WHI and HI, whereas WC showed similar associations to ABSI only in women.
Conclusions
This large MR study provides strong evidence for a potential causal positive association of the allometric indices ABSI and WHI with CRC in both sexes, thus establishing the association between abdominal fat and CRC without the limitations of the traditional waist size indices and independently of BMI. Among the BMI-adjusted traditional indices, WHR and HC provided equivalent associations with WHI and HI, while differences were observed between WC and ABSI.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>38297030</pmid><doi>10.1038/s41366-024-01479-6</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2421-6127</orcidid><orcidid>https://orcid.org/0000-0001-8494-732X</orcidid><orcidid>https://orcid.org/0000-0002-8452-8472</orcidid><orcidid>https://orcid.org/0000-0002-6129-1572</orcidid><orcidid>https://orcid.org/0000-0002-0127-9790</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0307-0565 |
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| issn | 0307-0565 1476-5497 1476-5497 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_846071 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature Journals Online; SWEPUB Freely available online |
| subjects | 692/499 692/699/67 Body Mass Index Body measurements Body size Colon Colon cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - epidemiology Colorectal Neoplasms - genetics Consortia Epidemiology Female Health Promotion and Disease Prevention Humans Internal Medicine Male Medicine Medicine & Public Health Men Mendelian Randomization Analysis - methods Metabolic Diseases Observational studies Public Health Randomization Rectum Risk Risk Factors Waist Circumference Waist-Hip Ratio Women |
| title | Allometric versus traditional body-shape indices and risk of colorectal cancer: a Mendelian randomization analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T15%3A42%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Allometric%20versus%20traditional%20body-shape%20indices%20and%20risk%20of%20colorectal%20cancer:%20a%20Mendelian%20randomization%20analysis&rft.jtitle=INTERNATIONAL%20JOURNAL%20OF%20OBESITY&rft.au=Rontogianni,%20Marina%20O.&rft.date=2024-05-01&rft.volume=48&rft.issue=5&rft.spage=709&rft.epage=716&rft.pages=709-716&rft.issn=0307-0565&rft.eissn=1476-5497&rft_id=info:doi/10.1038/s41366-024-01479-6&rft_dat=%3Cproquest_swepu%3E3048257459%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3048257459&rft_id=info:pmid/38297030&rfr_iscdi=true |