Survival of P. falciparum infected red blood cell aggregates in elongational shear flow
Rosetting, the formation of red blood cell aggregates, is a life-threatening condition in malaria tropica and not yet fully understood. We study rosette stability using a set of microfluidic stenotic channels, with varied narrowing angle and erythrocytes of blood groups O and A. We find reduced abil...
Gespeichert in:
| Veröffentlicht in: | Lab on a chip 2024-02, Vol.24 (4), p.787-797 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 797 |
|---|---|
| container_issue | 4 |
| container_start_page | 787 |
| container_title | Lab on a chip |
| container_volume | 24 |
| creator | Jötten, Anna M Schepp, Anabelle Machon, Adam Moll, Kirsten Wahlgren, Mats Krüger, Timm Westerhausen, Christoph |
| description | Rosetting, the formation of red blood cell aggregates, is a life-threatening condition in malaria tropica and not yet fully understood. We study rosette stability using a set of microfluidic stenotic channels, with varied narrowing angle and erythrocytes of blood groups O and A. We find reduced ability of a rosette to pass a stenosis without disruption, the longer the tapered part of the constriction and the narrower the stenosis is. In general, this ability increases with rosette size and is 5-15% higher in blood group A. The experimental results are substantiated by equivalent experiments using lectin-induced red blood cell aggregates and a simulation of the underlying protein binding kinetics. |
| doi_str_mv | 10.1039/d3lc00552f |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_841724</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2925490821</sourcerecordid><originalsourceid>FETCH-LOGICAL-c312t-8c3777cb4e8bb9e1fd1e6666026a3b58d210ee3704a99d6c6c64ff3c9cd50b213</originalsourceid><addsrcrecordid>eNpdkVtLAzEQhYMotlZf_AES8EWErbntbvIo1apQUFDxcclmJ3XrtqlJt8V_b3qxD2YIcxI-DjMchM4p6VPC1U3FG0NImjJ7gLpU5DwhVKrDvVZ5B52EMCGEpiKTx6jDJSOCs7SLPl5bv6yXusHO4pc-trox9Vz7dorrmQWzgAr7eMvGuQobaBqsx2MPY72AEBEMjZvFR-1m0SN8gvbYNm51io6iVYCzXe-h9-H92-AxGT0_PA1uR4nhlC0SaXie56YUIMtSAbUVhSwewjLNy1RWjBIAnhOhlaoyE0tYy40yVUpKRnkPJVvfsIJ5WxZzX0-1_ymcrovd11dUUEhBcyYif7Xl5959txAWxbQO67X0DFwbCqYoFyJnMovo5T904lof11xTLBWKyM0A11vKeBeCB7sfgZJiHU9xx0eDTTzDCF_sLNtyCtUe_cuD_wISpoot</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2925490821</pqid></control><display><type>article</type><title>Survival of P. falciparum infected red blood cell aggregates in elongational shear flow</title><source>MEDLINE</source><source>Royal Society Of Chemistry Journals 2008-</source><source>Alma/SFX Local Collection</source><source>SWEPUB Freely available online</source><creator>Jötten, Anna M ; Schepp, Anabelle ; Machon, Adam ; Moll, Kirsten ; Wahlgren, Mats ; Krüger, Timm ; Westerhausen, Christoph</creator><creatorcontrib>Jötten, Anna M ; Schepp, Anabelle ; Machon, Adam ; Moll, Kirsten ; Wahlgren, Mats ; Krüger, Timm ; Westerhausen, Christoph</creatorcontrib><description>Rosetting, the formation of red blood cell aggregates, is a life-threatening condition in malaria tropica and not yet fully understood. We study rosette stability using a set of microfluidic stenotic channels, with varied narrowing angle and erythrocytes of blood groups O and A. We find reduced ability of a rosette to pass a stenosis without disruption, the longer the tapered part of the constriction and the narrower the stenosis is. In general, this ability increases with rosette size and is 5-15% higher in blood group A. The experimental results are substantiated by equivalent experiments using lectin-induced red blood cell aggregates and a simulation of the underlying protein binding kinetics.</description><identifier>ISSN: 1473-0197</identifier><identifier>EISSN: 1473-0189</identifier><identifier>DOI: 10.1039/d3lc00552f</identifier><identifier>PMID: 38204325</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Aggregates ; Blood groups ; Constriction, Pathologic ; Erythrocytes ; Humans ; Malaria ; Malaria, Falciparum ; Plasmodium falciparum ; Protein Binding ; Shear flow</subject><ispartof>Lab on a chip, 2024-02, Vol.24 (4), p.787-797</ispartof><rights>Copyright Royal Society of Chemistry 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c312t-8c3777cb4e8bb9e1fd1e6666026a3b58d210ee3704a99d6c6c64ff3c9cd50b213</cites><orcidid>0000-0003-2934-2699 ; 0000-0001-7103-7060</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38204325$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:154668052$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Jötten, Anna M</creatorcontrib><creatorcontrib>Schepp, Anabelle</creatorcontrib><creatorcontrib>Machon, Adam</creatorcontrib><creatorcontrib>Moll, Kirsten</creatorcontrib><creatorcontrib>Wahlgren, Mats</creatorcontrib><creatorcontrib>Krüger, Timm</creatorcontrib><creatorcontrib>Westerhausen, Christoph</creatorcontrib><title>Survival of P. falciparum infected red blood cell aggregates in elongational shear flow</title><title>Lab on a chip</title><addtitle>Lab Chip</addtitle><description>Rosetting, the formation of red blood cell aggregates, is a life-threatening condition in malaria tropica and not yet fully understood. We study rosette stability using a set of microfluidic stenotic channels, with varied narrowing angle and erythrocytes of blood groups O and A. We find reduced ability of a rosette to pass a stenosis without disruption, the longer the tapered part of the constriction and the narrower the stenosis is. In general, this ability increases with rosette size and is 5-15% higher in blood group A. The experimental results are substantiated by equivalent experiments using lectin-induced red blood cell aggregates and a simulation of the underlying protein binding kinetics.</description><subject>Aggregates</subject><subject>Blood groups</subject><subject>Constriction, Pathologic</subject><subject>Erythrocytes</subject><subject>Humans</subject><subject>Malaria</subject><subject>Malaria, Falciparum</subject><subject>Plasmodium falciparum</subject><subject>Protein Binding</subject><subject>Shear flow</subject><issn>1473-0197</issn><issn>1473-0189</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNpdkVtLAzEQhYMotlZf_AES8EWErbntbvIo1apQUFDxcclmJ3XrtqlJt8V_b3qxD2YIcxI-DjMchM4p6VPC1U3FG0NImjJ7gLpU5DwhVKrDvVZ5B52EMCGEpiKTx6jDJSOCs7SLPl5bv6yXusHO4pc-trox9Vz7dorrmQWzgAr7eMvGuQobaBqsx2MPY72AEBEMjZvFR-1m0SN8gvbYNm51io6iVYCzXe-h9-H92-AxGT0_PA1uR4nhlC0SaXie56YUIMtSAbUVhSwewjLNy1RWjBIAnhOhlaoyE0tYy40yVUpKRnkPJVvfsIJ5WxZzX0-1_ymcrovd11dUUEhBcyYif7Xl5959txAWxbQO67X0DFwbCqYoFyJnMovo5T904lof11xTLBWKyM0A11vKeBeCB7sfgZJiHU9xx0eDTTzDCF_sLNtyCtUe_cuD_wISpoot</recordid><startdate>20240213</startdate><enddate>20240213</enddate><creator>Jötten, Anna M</creator><creator>Schepp, Anabelle</creator><creator>Machon, Adam</creator><creator>Moll, Kirsten</creator><creator>Wahlgren, Mats</creator><creator>Krüger, Timm</creator><creator>Westerhausen, Christoph</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SP</scope><scope>7TB</scope><scope>7U5</scope><scope>8FD</scope><scope>FR3</scope><scope>L7M</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0003-2934-2699</orcidid><orcidid>https://orcid.org/0000-0001-7103-7060</orcidid></search><sort><creationdate>20240213</creationdate><title>Survival of P. falciparum infected red blood cell aggregates in elongational shear flow</title><author>Jötten, Anna M ; Schepp, Anabelle ; Machon, Adam ; Moll, Kirsten ; Wahlgren, Mats ; Krüger, Timm ; Westerhausen, Christoph</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c312t-8c3777cb4e8bb9e1fd1e6666026a3b58d210ee3704a99d6c6c64ff3c9cd50b213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aggregates</topic><topic>Blood groups</topic><topic>Constriction, Pathologic</topic><topic>Erythrocytes</topic><topic>Humans</topic><topic>Malaria</topic><topic>Malaria, Falciparum</topic><topic>Plasmodium falciparum</topic><topic>Protein Binding</topic><topic>Shear flow</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jötten, Anna M</creatorcontrib><creatorcontrib>Schepp, Anabelle</creatorcontrib><creatorcontrib>Machon, Adam</creatorcontrib><creatorcontrib>Moll, Kirsten</creatorcontrib><creatorcontrib>Wahlgren, Mats</creatorcontrib><creatorcontrib>Krüger, Timm</creatorcontrib><creatorcontrib>Westerhausen, Christoph</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Electronics & Communications Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Lab on a chip</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jötten, Anna M</au><au>Schepp, Anabelle</au><au>Machon, Adam</au><au>Moll, Kirsten</au><au>Wahlgren, Mats</au><au>Krüger, Timm</au><au>Westerhausen, Christoph</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Survival of P. falciparum infected red blood cell aggregates in elongational shear flow</atitle><jtitle>Lab on a chip</jtitle><addtitle>Lab Chip</addtitle><date>2024-02-13</date><risdate>2024</risdate><volume>24</volume><issue>4</issue><spage>787</spage><epage>797</epage><pages>787-797</pages><issn>1473-0197</issn><eissn>1473-0189</eissn><abstract>Rosetting, the formation of red blood cell aggregates, is a life-threatening condition in malaria tropica and not yet fully understood. We study rosette stability using a set of microfluidic stenotic channels, with varied narrowing angle and erythrocytes of blood groups O and A. We find reduced ability of a rosette to pass a stenosis without disruption, the longer the tapered part of the constriction and the narrower the stenosis is. In general, this ability increases with rosette size and is 5-15% higher in blood group A. The experimental results are substantiated by equivalent experiments using lectin-induced red blood cell aggregates and a simulation of the underlying protein binding kinetics.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>38204325</pmid><doi>10.1039/d3lc00552f</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-2934-2699</orcidid><orcidid>https://orcid.org/0000-0001-7103-7060</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1473-0197 |
| ispartof | Lab on a chip, 2024-02, Vol.24 (4), p.787-797 |
| issn | 1473-0197 1473-0189 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_841724 |
| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection; SWEPUB Freely available online |
| subjects | Aggregates Blood groups Constriction, Pathologic Erythrocytes Humans Malaria Malaria, Falciparum Plasmodium falciparum Protein Binding Shear flow |
| title | Survival of P. falciparum infected red blood cell aggregates in elongational shear flow |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T18%3A53%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Survival%20of%20P.%20falciparum%20infected%20red%20blood%20cell%20aggregates%20in%20elongational%20shear%20flow&rft.jtitle=Lab%20on%20a%20chip&rft.au=J%C3%B6tten,%20Anna%20M&rft.date=2024-02-13&rft.volume=24&rft.issue=4&rft.spage=787&rft.epage=797&rft.pages=787-797&rft.issn=1473-0197&rft.eissn=1473-0189&rft_id=info:doi/10.1039/d3lc00552f&rft_dat=%3Cproquest_swepu%3E2925490821%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2925490821&rft_id=info:pmid/38204325&rfr_iscdi=true |