Dysregulated germinal center reaction with expanded T follicular helper cells in autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy lymph nodes

Autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED, also called APS-1) is an inborn error of immunity with clear signs of B-cell autoimmunity such as neutralizing anti-IFN antibodies. In APECED, mutations in the AIRE gene impair thymic negative selection of T cells. The resulting...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2024-05, Vol.153 (5), p.1445-1455
Hauptverfasser:	Hetemäki, Iivo, Sarkkinen, Joona, Heikkilä, Nelli, Drechsel, Karen, Mäyränpää, Mikko I., Färkkilä, Anniina, Laakso, Saila, Mäkitie, Outi, Arstila, T. Petteri, Kekäläinen, Eliisa
Format:	Artikel
Sprache:	eng
Schlagworte:	AIRE autoantibody B cell follicular regulatory T cell follicular T helper cell inborn error of immunity regulatory T cell
Online-Zugang:	Volltext
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