Harnessing T cell exhaustion and trogocytosis to isolate patient-derived tumor-specific TCR

To study and then harness the tumor-specific T cell dynamics after allogeneic hematopoietic stem cell transplant, we typed the frequency, phenotype, and function of lymphocytes directed against tumor-associated antigens (TAAs) in 39 consecutive transplanted patients, for 1 year after transplant. We...

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Veröffentlicht in:	Science advances 2023-12, Vol.9 (48), p.eadg8014-eadg8014
Hauptverfasser:	Manfredi, Francesco, Stasi, Lorena, Buonanno, Silvia, Marzuttini, Francesca, Noviello, Maddalena, Mastaglio, Sara, Abbati, Danilo, Potenza, Alessia, Balestrieri, Chiara, Cianciotti, Beatrice Claudia, Tassi, Elena, Feola, Sara, Toffalori, Cristina, Punta, Marco, Magnani, Zulma, Camisa, Barbara, Tiziano, Elena, Lupo-Stanghellini, Maria Teresa, Branca, Rui Mamede, Lehtiö, Janne, Sikanen, Tiina M, Haapala, Markus J, Cerullo, Vincenzo, Casucci, Monica, Vago, Luca, Ciceri, Fabio, Bonini, Chiara, Ruggiero, Eliana
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Neoplasm Humans Leukemia, Myeloid, Acute - therapy Receptors, Antigen, T-Cell - genetics T-Cell Exhaustion T-Lymphocytes Trogocytosis
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