Biochemical activity induced by a germline variation in KLK3 (PSA) associates with cellular function and clinical outcome in prostate cancer

Genetic variation at the 19q13.3 locus is linked with prostate cancer susceptibility. The non-synonymous SNP, rs17632542 (c.536T>C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional relevance is unknown. Here, we identify that the SNP variant-...

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Veröffentlicht in:	RES SQ 2023-03, p.rs.3.rs
Hauptverfasser:	Srinivasan, Srilakshmi, Kryza, Thomas, Bock, Nathalie, Tse, Brian Wc, Sokolowski, Kamil A, Panchadsaram, Janaththani, Moya, Leire, Stephens, Carson, Dong, Ying, Röhl, Joan, Alinezhad, Saeid, Vela, Ian, Perry-Keene, Joanna L, Buzacott, Katie, Gago-Dominguez, Manuela, Schleutker, Johanna, Maier, Christiane, Muir, Kenneth, Tangen, Catherine M, Gronberg, Henrik, Pashayan, Nora, Albanes, Demetrius, Wolk, Alicja, Stanford, Janet L, Berndt, Sonja I, Mucci, Lorelei A, Koutros, Stella, Cussenot, Olivier, Sorensen, Karina Dalsgaard, Grindedal, Eli Marie, Key, Timothy J, Haiman, Christopher A, Giles, Graham G, Vega, Ana, Wiklund, Fredrik, Neal, David E, Kogevinas, Manolis, Stampfer, Meir J, Nordestgaard, Børge G, Brenner, Hermann, Gamulin, Marija, Claessens, Frank, Melander, Olle, Dahlin, Anders, Stattin, Pär, Hallmans, Göran, Häggström, Christel, Johansson, Robert, Thysell, Elin, Rönn, Ann-Charlotte, Li, Weiqiang, Brown, Nigel, Dimeski, Goce, Shepherd, Benjamin, Dadaev, Tokhir, Brook, Mark N, Spurdle, Amanda B, Stenman, Ulf-Håkan, Koistinen, Hannu, Kote-Jarai, Zsofia, Klein, Robert J, Lilja, Hans, Ecker, Rupert C, Eeles, Rosalind, Clements, Judith, Batra, Jyotsna
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Sprache:	eng
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