Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial

The optimum curative approach to adenocarcinoma of the oesophagus and oesophagogastric junction is unknown. We aimed to compare trimodality therapy (preoperative radiotherapy with carboplatin plus paclitaxel [CROSS regimen]) with optimum contemporaneous perioperative chemotherapy regimens (epirubici...

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Veröffentlicht in:	LANCET GASTROENTEROLOGY & HEPATOLOGY 2023-11, Vol.8 (11), p.1015-1027
Hauptverfasser:	Reynolds, John V, Preston, Shaun R, O'Neill, Brian, Lowery, Maeve A, Baeksgaard, Lene, Crosby, Thomas, Cunningham, Moya, Cuffe, Sinead, Griffiths, Gareth O, Parker, Imelda, Risumlund, Signe Lenora, Roy, Rajarshi, Falk, Stephen, Hanna, George B, Bartlett, Frederick R, Alvarez-Iglesias, Alberto, Achiam, Michael P, Nilsson, Magnus, Piessen, Guillaume, Ravi, Narayanasamy, O'Toole, Dermot, Johnston, Ciaran, McDermott, Raymond S, Turkington, Richard C, Wahed, Shajahan, Sothi, Sharmila, Ford, Hugo, Wadley, Martin S, Power, Derek, Mukherjee, Somnath, Morgan, Carys, Parsons, Simon L, Bhuva, Neel, Campbell, Sorcha, Grogan, Liam, Leonard, Greg, Bateman, Andrew R, Mitchell, Catherine, O'Reilly, Seamus, Mulroe, Eibhlin, McLoughlin, Olivia, Shevlin, Anna, Shannon, Aoife M, Marron, Jacinta, Nolan, Marc, Burch, Grace, Costello, Michelle, Griffiths, Daniel, Cozens, Kelly, Foley, Emma, Donohoe, Claire L, O'Farrell, Catherine, Moore, Jennifer, O'Sullivan, Jacintha
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - drug therapy Antineoplastic Combined Chemotherapy Protocols - therapeutic use Cancer Capecitabine Carboplatin - therapeutic use Cisplatin Docetaxel Epirubicin - therapeutic use Esophageal Neoplasms - drug therapy Esophagogastric Junction - pathology Female Fluorouracil - therapeutic use Humans Leucovorin - therapeutic use Life Sciences Male Oxaliplatin Paclitaxel - therapeutic use Pandemics Quality of Life
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