Discharge Against Medical Advice in Acute Ischemic Stroke: the Risk of 30-Day Unplanned Readmission

Background Discharge against medical advice may be associated with more readmissions. Objective To evaluate DAMA in patients with acute ischemic stroke (AIS) and identify the relationship between DAMA and 30-day unplanned readmissions. Design A retrospective cohort study. Participants The National R...

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Veröffentlicht in:Journal of general internal medicine : JGIM 2021-05, Vol.36 (5), p.1206-1213
Hauptverfasser: Lin, Zhen, Han, Hedong, Wu, Cheng, Wei, Xin, Ruan, Yiming, Zhang, Chenxu, Cao, Yang, He, Jia
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container_end_page 1213
container_issue 5
container_start_page 1206
container_title Journal of general internal medicine : JGIM
container_volume 36
creator Lin, Zhen
Han, Hedong
Wu, Cheng
Wei, Xin
Ruan, Yiming
Zhang, Chenxu
Cao, Yang
He, Jia
description Background Discharge against medical advice may be associated with more readmissions. Objective To evaluate DAMA in patients with acute ischemic stroke (AIS) and identify the relationship between DAMA and 30-day unplanned readmissions. Design A retrospective cohort study. Participants The National Readmission Database was used to identify inpatients with a primary diagnosis of AIS who were either discharged home or DAMA between 2010 and 2017 in the USA. Measures Demographic features, hospital type, comorbidities, stroke risk factors, severity indices, and treatments were compared between patients discharged routinely and DAMA. Multivariable logistic regression was used to evaluate predictors of DAMA, and a double robust inverse probability of treatment weighting method was used to assess the association between DAMA and 30-day unplanned readmissions. Key Results Overall, 1,335,484 patients with AIS were included, of whom 2.09% ( n = 27,892) were DAMA. The prevalence of DAMA in AIS patients increased from 1.65 in 2010 to 2.57% in 2017. The rates of 30-day unplanned readmissions for DAMA and non-DAMA patients were 16.81% and 7.78%, respectively. Patients with drug abuse, alcohol abuse, smoking, prior stroke, psychoses, and intravenous thrombolysis had greater odds of DAMA. DAMA was associated with all-cause readmissions (OR, 2.04; 95% CI, 2.01–2.07) and remained a strong predictor for transient ischemic attack/stroke-specific and cardiac-specific causes of readmissions. Conclusions Although the DAMA rate is low in AIS patients, DAMA is a risk factor for all-cause and recurrent stroke-specific readmissions. Future studies are needed to address issues around compliance and engagement with health care to reduce DAMA.
doi_str_mv 10.1007/s11606-020-06366-0
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Objective To evaluate DAMA in patients with acute ischemic stroke (AIS) and identify the relationship between DAMA and 30-day unplanned readmissions. Design A retrospective cohort study. Participants The National Readmission Database was used to identify inpatients with a primary diagnosis of AIS who were either discharged home or DAMA between 2010 and 2017 in the USA. Measures Demographic features, hospital type, comorbidities, stroke risk factors, severity indices, and treatments were compared between patients discharged routinely and DAMA. Multivariable logistic regression was used to evaluate predictors of DAMA, and a double robust inverse probability of treatment weighting method was used to assess the association between DAMA and 30-day unplanned readmissions. Key Results Overall, 1,335,484 patients with AIS were included, of whom 2.09% ( n = 27,892) were DAMA. The prevalence of DAMA in AIS patients increased from 1.65 in 2010 to 2.57% in 2017. The rates of 30-day unplanned readmissions for DAMA and non-DAMA patients were 16.81% and 7.78%, respectively. Patients with drug abuse, alcohol abuse, smoking, prior stroke, psychoses, and intravenous thrombolysis had greater odds of DAMA. DAMA was associated with all-cause readmissions (OR, 2.04; 95% CI, 2.01–2.07) and remained a strong predictor for transient ischemic attack/stroke-specific and cardiac-specific causes of readmissions. Conclusions Although the DAMA rate is low in AIS patients, DAMA is a risk factor for all-cause and recurrent stroke-specific readmissions. Future studies are needed to address issues around compliance and engagement with health care to reduce DAMA.</description><identifier>ISSN: 0884-8734</identifier><identifier>ISSN: 1525-1497</identifier><identifier>EISSN: 1525-1497</identifier><identifier>DOI: 10.1007/s11606-020-06366-0</identifier><identifier>PMID: 33559060</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Acute ischemic stroke ; Alcohol abuse ; Brain Ischemia - diagnosis ; Brain Ischemia - epidemiology ; Brain Ischemia - therapy ; discharge against medical advice ; Drug abuse ; Evaluation ; Health risks ; Humans ; Internal Medicine ; Intravenous administration ; Ischemia ; Ischemic Stroke ; Medicin och hälsovetenskap ; Medicine ; Medicine &amp; Public Health ; Original Research ; Patient Discharge ; Patient Readmission ; Patients ; Psychosis ; readmission ; Retrospective Studies ; Risk analysis ; risk factor ; Risk Factors ; Statistical analysis ; Stroke ; Stroke - diagnosis ; Stroke - epidemiology ; Stroke - therapy ; Thrombolysis ; Transient ischemic attack ; Weighting methods</subject><ispartof>Journal of general internal medicine : JGIM, 2021-05, Vol.36 (5), p.1206-1213</ispartof><rights>Society of General Internal Medicine 2021</rights><rights>Society of General Internal Medicine 2021.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c599t-ff3cddc7017c2b2c7a477bcd246ed090f0169532f95b535d2bda2715121b8f303</citedby><cites>FETCH-LOGICAL-c599t-ff3cddc7017c2b2c7a477bcd246ed090f0169532f95b535d2bda2715121b8f303</cites><orcidid>0000-0002-2338-9501</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131431/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131431/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,552,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33559060$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-89481$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:145996672$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Zhen</creatorcontrib><creatorcontrib>Han, Hedong</creatorcontrib><creatorcontrib>Wu, Cheng</creatorcontrib><creatorcontrib>Wei, Xin</creatorcontrib><creatorcontrib>Ruan, Yiming</creatorcontrib><creatorcontrib>Zhang, Chenxu</creatorcontrib><creatorcontrib>Cao, Yang</creatorcontrib><creatorcontrib>He, Jia</creatorcontrib><title>Discharge Against Medical Advice in Acute Ischemic Stroke: the Risk of 30-Day Unplanned Readmission</title><title>Journal of general internal medicine : JGIM</title><addtitle>J GEN INTERN MED</addtitle><addtitle>J Gen Intern Med</addtitle><description>Background Discharge against medical advice may be associated with more readmissions. Objective To evaluate DAMA in patients with acute ischemic stroke (AIS) and identify the relationship between DAMA and 30-day unplanned readmissions. Design A retrospective cohort study. Participants The National Readmission Database was used to identify inpatients with a primary diagnosis of AIS who were either discharged home or DAMA between 2010 and 2017 in the USA. Measures Demographic features, hospital type, comorbidities, stroke risk factors, severity indices, and treatments were compared between patients discharged routinely and DAMA. Multivariable logistic regression was used to evaluate predictors of DAMA, and a double robust inverse probability of treatment weighting method was used to assess the association between DAMA and 30-day unplanned readmissions. Key Results Overall, 1,335,484 patients with AIS were included, of whom 2.09% ( n = 27,892) were DAMA. The prevalence of DAMA in AIS patients increased from 1.65 in 2010 to 2.57% in 2017. The rates of 30-day unplanned readmissions for DAMA and non-DAMA patients were 16.81% and 7.78%, respectively. Patients with drug abuse, alcohol abuse, smoking, prior stroke, psychoses, and intravenous thrombolysis had greater odds of DAMA. DAMA was associated with all-cause readmissions (OR, 2.04; 95% CI, 2.01–2.07) and remained a strong predictor for transient ischemic attack/stroke-specific and cardiac-specific causes of readmissions. Conclusions Although the DAMA rate is low in AIS patients, DAMA is a risk factor for all-cause and recurrent stroke-specific readmissions. Future studies are needed to address issues around compliance and engagement with health care to reduce DAMA.</description><subject>Acute ischemic stroke</subject><subject>Alcohol abuse</subject><subject>Brain Ischemia - diagnosis</subject><subject>Brain Ischemia - epidemiology</subject><subject>Brain Ischemia - therapy</subject><subject>discharge against medical advice</subject><subject>Drug abuse</subject><subject>Evaluation</subject><subject>Health risks</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Intravenous administration</subject><subject>Ischemia</subject><subject>Ischemic Stroke</subject><subject>Medicin och hälsovetenskap</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Original Research</subject><subject>Patient Discharge</subject><subject>Patient Readmission</subject><subject>Patients</subject><subject>Psychosis</subject><subject>readmission</subject><subject>Retrospective Studies</subject><subject>Risk analysis</subject><subject>risk factor</subject><subject>Risk Factors</subject><subject>Statistical analysis</subject><subject>Stroke</subject><subject>Stroke - diagnosis</subject><subject>Stroke - epidemiology</subject><subject>Stroke - therapy</subject><subject>Thrombolysis</subject><subject>Transient ischemic attack</subject><subject>Weighting methods</subject><issn>0884-8734</issn><issn>1525-1497</issn><issn>1525-1497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><sourceid>D8T</sourceid><recordid>eNp9kk9vFCEAxYnR2LX6BTwYEi8eHOU_jAeTSbdqkxqTar0SBphdurPDCjM1_fZl3W1rTeqBQOD3HvDyAHiJ0TuMkHyfMRZIVIigCgkqyuoRmGFOeIVZLR-DGVKKVUpSdgCe5XyBEKaEqKfggFLOayTQDNh5yHZp0sLDZmHCkEf41btgTQ8bdxmsh2GAjZ1GD08K6NfBwu9jiiv_AY5LD89CXsHYQYqqubmC58OmN8PgHTzzxq1DziEOz8GTzvTZv9jPh-D80_GPoy_V6bfPJ0fNaWV5XY9V11HrnJUIS0taYqVhUrbWESa8QzXqEBY1p6Srecspd6R1hkjMMcGt6iiih6Da-ebffjO1epPC2qQrHU3Q-61VWXktkSqmha8f5DcpujvRjRCz8lIhJCnatw9q5-Fno2NalDFpVTOFC_5xhxd27Z31w5hMf__GeydDWOpFvNRFixndGrzZG6T4a_J51CVc6_uSto9T1oQpKVnNqCzo63_QiziloSSvCSdKUEXV9vNkR9kUc06-u30MRnpbL72rly710n_qpbcJv_r7G7eSmz4VgO5jKUfDwqe7u_9jew3Iy9v8</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>Lin, Zhen</creator><creator>Han, Hedong</creator><creator>Wu, Cheng</creator><creator>Wei, Xin</creator><creator>Ruan, Yiming</creator><creator>Zhang, Chenxu</creator><creator>Cao, Yang</creator><creator>He, Jia</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D91</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-2338-9501</orcidid></search><sort><creationdate>20210501</creationdate><title>Discharge Against Medical Advice in Acute Ischemic Stroke: the Risk of 30-Day Unplanned Readmission</title><author>Lin, Zhen ; 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Objective To evaluate DAMA in patients with acute ischemic stroke (AIS) and identify the relationship between DAMA and 30-day unplanned readmissions. Design A retrospective cohort study. Participants The National Readmission Database was used to identify inpatients with a primary diagnosis of AIS who were either discharged home or DAMA between 2010 and 2017 in the USA. Measures Demographic features, hospital type, comorbidities, stroke risk factors, severity indices, and treatments were compared between patients discharged routinely and DAMA. Multivariable logistic regression was used to evaluate predictors of DAMA, and a double robust inverse probability of treatment weighting method was used to assess the association between DAMA and 30-day unplanned readmissions. Key Results Overall, 1,335,484 patients with AIS were included, of whom 2.09% ( n = 27,892) were DAMA. The prevalence of DAMA in AIS patients increased from 1.65 in 2010 to 2.57% in 2017. The rates of 30-day unplanned readmissions for DAMA and non-DAMA patients were 16.81% and 7.78%, respectively. Patients with drug abuse, alcohol abuse, smoking, prior stroke, psychoses, and intravenous thrombolysis had greater odds of DAMA. DAMA was associated with all-cause readmissions (OR, 2.04; 95% CI, 2.01–2.07) and remained a strong predictor for transient ischemic attack/stroke-specific and cardiac-specific causes of readmissions. Conclusions Although the DAMA rate is low in AIS patients, DAMA is a risk factor for all-cause and recurrent stroke-specific readmissions. Future studies are needed to address issues around compliance and engagement with health care to reduce DAMA.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33559060</pmid><doi>10.1007/s11606-020-06366-0</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-2338-9501</orcidid><oa>free_for_read</oa></addata></record>
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subjects Acute ischemic stroke
Alcohol abuse
Brain Ischemia - diagnosis
Brain Ischemia - epidemiology
Brain Ischemia - therapy
discharge against medical advice
Drug abuse
Evaluation
Health risks
Humans
Internal Medicine
Intravenous administration
Ischemia
Ischemic Stroke
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Original Research
Patient Discharge
Patient Readmission
Patients
Psychosis
readmission
Retrospective Studies
Risk analysis
risk factor
Risk Factors
Statistical analysis
Stroke
Stroke - diagnosis
Stroke - epidemiology
Stroke - therapy
Thrombolysis
Transient ischemic attack
Weighting methods
title Discharge Against Medical Advice in Acute Ischemic Stroke: the Risk of 30-Day Unplanned Readmission
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