Combining Asian-European Genome-Wide Association Studies of Colorectal Cancer Improves Risk Prediction Across Race and Ethnicity

Polygenic risk scores (PRS) have great potential to guide precision colorectal cancer (CRC) prevention by identifying those at higher risk to undertake targeted screening. However, current PRS using European ancestry data have sub-optimal performance in non-European ancestry populations, limiting th...

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Veröffentlicht in:	MEDRXIV 2023-01
Hauptverfasser:	Thomas, Minta, Su, Yu-Ru, Rosenthal, Elisabeth A, Sakoda, Lori C, Schmit, Stephanie L, Timofeeva, Maria N, Chen, Zhishan, Fernandez-Rozadilla, Ceres, Law, Philip J, Murphy, Neil, Carreras-Torres, Robert, Diez-Obrero, Virginia, van Duijnhoven, Franzel Jb, Jiang, Shangqing, Shin, Aesun, Wolk, Alicja, Phipps, Amanda I, Burnett-Hartman, Andrea, Gsur, Andrea, Chan, Andrew T, Zauber, Ann G, Wu, Anna H, Lindblom, Annika, Um, Caroline Y, Tangen, Catherine M, Gignoux, Chris, Newton, Christina, Haiman, Christopher A, Qu, Conghui, Bishop, D Timothy, Buchanan, Daniel D, Crosslin, David R, Conti, David V, Kim, Dong-Hyun, Hauser, Elizabeth, White, Emily, Siegel, Erin, Schumacher, Fredrick R, Rennert, Gad, Giles, Graham G, Hampel, Heather, Brenner, Hermann, Oze, Isao, Oh, Jae Hwan, Lee, Jeffrey K, Schneider, Jennifer L, Chang-Claude, Jenny, Kim, Jeongseon, Huyghe, Jeroen R, Zheng, Jiayin, Hampe, Jochen, Greenson, Joel, Hopper, John L, Palmer, Julie R, Visvanathan, Kala, Matsuo, Keitaro, Matsuda, Koichi, Jung, Keum Ji, Li, Li, Marchand, Loic Le, Vodickova, Ludmila, Bujanda, Luis, Gunter, Marc J, Matejcic, Marco, Jenkins, Mark A, Slattery, Martha L, D'Amato, Mauro, Wang, Meilin, Hoffmeister, Michael, Woods, Michael O, Kim, Michelle, Song, Mingyang, Iwasaki, Motoki, Du, Mulong, Udaltsova, Natalia, Sawada, Norie, Vodicka, Pavel, Campbell, Peter T, Newcomb, Polly A, Cai, Qiuyin, Pearlman, Rachel, Pai, Rish K, Schoen, Robert E, Steinfelder, Robert S, Haile, Robert W, Vandenputtelaar, Rosita, Prentice, Ross L, Küry, Sébastien, Castellví-Bel, Sergi, Tsugane, Shoichiro, Berndt, Sonja I, Lee, Soo Chin, Brezina, Stefanie, Weinstein, Stephanie J, Chanock, Stephen J, Jee, Sun Ha, Kweon, Sun-Seog, Vadaparampil, Susan, Harrison, Tabitha A, Yamaji, Taiki
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Sprache:	eng
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