Resectability, Resections, Survival Outcomes, and Quality of Life in Older Adult Patients with Metastatic Colorectal Cancer (the RAXO-Study)

Resectability, Resections, Survival Outcomes, and Quality of Life in Older Adult Patients with Metastatic Colorectal Cancer (the RAXO-Study)

Older adults are underrepresented in metastatic colorectal cancer (mCRC) studies and thus may not receive optimal treatment, especially not metastasectomies. The prospective Finnish real-life RAXO-study included 1086 any organ mCRC patients. We assessed repeated centralized resectability, overall su...

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Veröffentlicht in:JOURNAL OF CLINICAL MEDICINE 2023-05, Vol.12 (10), p.3541
Hauptverfasser: Lehtomäki, Kaisa, Soveri, Leena-Maija, Osterlund, Emerik, Lamminmäki, Annamarja, Uutela, Aki, Heervä, Eetu, Halonen, Päivi, Stedt, Hanna, Aho, Sonja, Muhonen, Timo, Ålgars, Annika, Salminen, Tapio, Kallio, Raija, Nordin, Arno, Aroviita, Laura, Nyandoto, Paul, Kononen, Juha, Glimelius, Bengt, Ristamäki, Raija, Isoniemi, Helena, Osterlund, Pia
Format: Artikel
Sprache:eng
Schlagworte:
Ablation (Surgery)
Age
Aged patients
Cancer therapies
Care and treatment
Clinical medicine
Colorectal cancer
Confidence intervals
cytoreductive surgery
Decision making
Development and progression
Diagnosis
Health aspects
health-related quality of life
Hospitals
Liver
liver resection
local ablative therapy
lung resection
metastasectomy
Metastasis
metastatic colorectal cancer
older adults
Older people
oncological treatment
Patient outcomes
Patients
Quality of life
Questionnaires
Remission (Medicine)
Surgeons
Tomography
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Zusammenfassung:Older adults are underrepresented in metastatic colorectal cancer (mCRC) studies and thus may not receive optimal treatment, especially not metastasectomies. The prospective Finnish real-life RAXO-study included 1086 any organ mCRC patients. We assessed repeated centralized resectability, overall survival (OS), and quality of life (QoL) using 15D and EORTC QLQ-C30/CR29. Older adults (>75 years; n = 181, 17%) had worse ECOG performance status than adults (
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12103541