Inverse association between Mediterranean diet and risk of multiple sclerosis
Objective: There is some evidence implicating diet in the development of inflammatory diseases. We aimed to study the influence of dietary habits on the risk of developing multiple sclerosis (MS). Methods: We used a population-based case–control study recruiting incident cases of MS (1953 cases, 355...
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| Veröffentlicht in: | Multiple sclerosis 2023-08, Vol.29 (9), p.1118-1125 |
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| container_title | Multiple sclerosis |
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| creator | Alfredsson, Lars Olsson, Tomas Hedström, Anna Karin |
| description | Objective:
There is some evidence implicating diet in the development of inflammatory diseases. We aimed to study the influence of dietary habits on the risk of developing multiple sclerosis (MS).
Methods:
We used a population-based case–control study recruiting incident cases of MS (1953 cases, 3557 controls). Subjects with different dietary habits 5 years prior to MS diagnosis were compared regarding MS risk by calculating odds ratios (OR) with 95% confidence intervals (CI) using logistic regression models. Adjustment was made for a large number of environmental and lifestyle habits, including ancestry, smoking, alcohol consumption, body mass index, physical activity, and sun exposure habits.
Results:
Mediterranean diet was associated with lower risk of developing MS (adjusted OR = 0.54, 95% CI: 0.34–0.86, p = 0.009), compared with Western-style diet. There was no significant association between vegetarian/vegan diet and MS risk (adjusted OR = 0.96, 95% CI: 0.75–1.24, p = 0.976), nor between diet with low glycemic index and MS risk (adjusted OR = 0.93, 95% CI: 0.60–1.42, p = 0.518).
Conclusions:
Mediterranean diet may exert a protective influence regarding the risk of subsequently developing MS compared with Western-style diet. |
| doi_str_mv | 10.1177/13524585231181841 |
| format | Article |
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There is some evidence implicating diet in the development of inflammatory diseases. We aimed to study the influence of dietary habits on the risk of developing multiple sclerosis (MS).
Methods:
We used a population-based case–control study recruiting incident cases of MS (1953 cases, 3557 controls). Subjects with different dietary habits 5 years prior to MS diagnosis were compared regarding MS risk by calculating odds ratios (OR) with 95% confidence intervals (CI) using logistic regression models. Adjustment was made for a large number of environmental and lifestyle habits, including ancestry, smoking, alcohol consumption, body mass index, physical activity, and sun exposure habits.
Results:
Mediterranean diet was associated with lower risk of developing MS (adjusted OR = 0.54, 95% CI: 0.34–0.86, p = 0.009), compared with Western-style diet. There was no significant association between vegetarian/vegan diet and MS risk (adjusted OR = 0.96, 95% CI: 0.75–1.24, p = 0.976), nor between diet with low glycemic index and MS risk (adjusted OR = 0.93, 95% CI: 0.60–1.42, p = 0.518).
Conclusions:
Mediterranean diet may exert a protective influence regarding the risk of subsequently developing MS compared with Western-style diet.</description><identifier>ISSN: 1352-4585</identifier><identifier>ISSN: 1477-0970</identifier><identifier>EISSN: 1477-0970</identifier><identifier>DOI: 10.1177/13524585231181841</identifier><identifier>PMID: 37366345</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Alcohol Drinking ; Body mass index ; Case-Control Studies ; Diet ; Diet, Mediterranean ; Humans ; Inflammatory diseases ; Medicin och hälsovetenskap ; Multiple sclerosis ; Multiple Sclerosis - epidemiology ; Multiple Sclerosis - etiology ; Multiple Sclerosis - prevention & control ; Nutrient deficiency ; Physical activity ; Population studies ; Regression analysis ; Risk Factors ; Vegetarian diet ; Vegetarianism</subject><ispartof>Multiple sclerosis, 2023-08, Vol.29 (9), p.1118-1125</ispartof><rights>The Author(s), 2023</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-2f9dd57f02811b4f3356a2e76403dc88c9e830f67b3bfc42e9f17935faeaba4f3</citedby><cites>FETCH-LOGICAL-c456t-2f9dd57f02811b4f3356a2e76403dc88c9e830f67b3bfc42e9f17935faeaba4f3</cites><orcidid>0000-0002-6612-4749</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/13524585231181841$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/13524585231181841$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>230,315,781,785,886,21824,27929,27930,43626,43627</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37366345$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:153040059$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Alfredsson, Lars</creatorcontrib><creatorcontrib>Olsson, Tomas</creatorcontrib><creatorcontrib>Hedström, Anna Karin</creatorcontrib><title>Inverse association between Mediterranean diet and risk of multiple sclerosis</title><title>Multiple sclerosis</title><addtitle>Mult Scler</addtitle><description>Objective:
There is some evidence implicating diet in the development of inflammatory diseases. We aimed to study the influence of dietary habits on the risk of developing multiple sclerosis (MS).
Methods:
We used a population-based case–control study recruiting incident cases of MS (1953 cases, 3557 controls). Subjects with different dietary habits 5 years prior to MS diagnosis were compared regarding MS risk by calculating odds ratios (OR) with 95% confidence intervals (CI) using logistic regression models. Adjustment was made for a large number of environmental and lifestyle habits, including ancestry, smoking, alcohol consumption, body mass index, physical activity, and sun exposure habits.
Results:
Mediterranean diet was associated with lower risk of developing MS (adjusted OR = 0.54, 95% CI: 0.34–0.86, p = 0.009), compared with Western-style diet. There was no significant association between vegetarian/vegan diet and MS risk (adjusted OR = 0.96, 95% CI: 0.75–1.24, p = 0.976), nor between diet with low glycemic index and MS risk (adjusted OR = 0.93, 95% CI: 0.60–1.42, p = 0.518).
Conclusions:
Mediterranean diet may exert a protective influence regarding the risk of subsequently developing MS compared with Western-style diet.</description><subject>Alcohol Drinking</subject><subject>Body mass index</subject><subject>Case-Control Studies</subject><subject>Diet</subject><subject>Diet, Mediterranean</subject><subject>Humans</subject><subject>Inflammatory diseases</subject><subject>Medicin och hälsovetenskap</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - epidemiology</subject><subject>Multiple Sclerosis - etiology</subject><subject>Multiple Sclerosis - prevention & control</subject><subject>Nutrient deficiency</subject><subject>Physical activity</subject><subject>Population studies</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>Vegetarian diet</subject><subject>Vegetarianism</subject><issn>1352-4585</issn><issn>1477-0970</issn><issn>1477-0970</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9P3DAQxS1UxG6BD9BLZakXLgGP__tYodIigbjAOXKScWU2m2ztpIhvX6NdQCrak0f2782M3yPkC7BzAGMuQCgulVVcAFiwEg7IEqQxFXOGfSp1ea9egAX5nPMjY8wYoY7IQhihtZBqSW6vh7-YMlKf89hGP8VxoA1OT4gDvcUuTpiSH9APtIs4UT90NMW8omOg67mf4qZHmtse05hjPiGHwfcZT3fnMXm4-nF_-au6uft5ffn9pmql0lPFg-s6ZQLjFqCRQQilPUejJRNda23r0AoWtGlEE1rJ0QUwTqjg0Te-8Mek2vbNT7iZm3qT4tqn53r0sd5drUqFtVbgnCq828tv0ti9i16FoASTjClXtGdbbQH_zJineh1zi31fXBnnXPOyKgftrC7ot__Qx3FOQ3GiUNKCZIazQsGWaotnOWF4WwdY_ZJr_SHXovm66zw3a-zeFK9BFuB890P_G9_H7u_4D4jRq4k</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Alfredsson, Lars</creator><creator>Olsson, Tomas</creator><creator>Hedström, Anna Karin</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><orcidid>https://orcid.org/0000-0002-6612-4749</orcidid></search><sort><creationdate>20230801</creationdate><title>Inverse association between Mediterranean diet and risk of multiple sclerosis</title><author>Alfredsson, Lars ; Olsson, Tomas ; Hedström, Anna Karin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-2f9dd57f02811b4f3356a2e76403dc88c9e830f67b3bfc42e9f17935faeaba4f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alcohol Drinking</topic><topic>Body mass index</topic><topic>Case-Control Studies</topic><topic>Diet</topic><topic>Diet, Mediterranean</topic><topic>Humans</topic><topic>Inflammatory diseases</topic><topic>Medicin och hälsovetenskap</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - epidemiology</topic><topic>Multiple Sclerosis - etiology</topic><topic>Multiple Sclerosis - prevention & control</topic><topic>Nutrient deficiency</topic><topic>Physical activity</topic><topic>Population studies</topic><topic>Regression analysis</topic><topic>Risk Factors</topic><topic>Vegetarian diet</topic><topic>Vegetarianism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alfredsson, Lars</creatorcontrib><creatorcontrib>Olsson, Tomas</creatorcontrib><creatorcontrib>Hedström, Anna Karin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Multiple sclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alfredsson, Lars</au><au>Olsson, Tomas</au><au>Hedström, Anna Karin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inverse association between Mediterranean diet and risk of multiple sclerosis</atitle><jtitle>Multiple sclerosis</jtitle><addtitle>Mult Scler</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>29</volume><issue>9</issue><spage>1118</spage><epage>1125</epage><pages>1118-1125</pages><issn>1352-4585</issn><issn>1477-0970</issn><eissn>1477-0970</eissn><abstract>Objective:
There is some evidence implicating diet in the development of inflammatory diseases. We aimed to study the influence of dietary habits on the risk of developing multiple sclerosis (MS).
Methods:
We used a population-based case–control study recruiting incident cases of MS (1953 cases, 3557 controls). Subjects with different dietary habits 5 years prior to MS diagnosis were compared regarding MS risk by calculating odds ratios (OR) with 95% confidence intervals (CI) using logistic regression models. Adjustment was made for a large number of environmental and lifestyle habits, including ancestry, smoking, alcohol consumption, body mass index, physical activity, and sun exposure habits.
Results:
Mediterranean diet was associated with lower risk of developing MS (adjusted OR = 0.54, 95% CI: 0.34–0.86, p = 0.009), compared with Western-style diet. There was no significant association between vegetarian/vegan diet and MS risk (adjusted OR = 0.96, 95% CI: 0.75–1.24, p = 0.976), nor between diet with low glycemic index and MS risk (adjusted OR = 0.93, 95% CI: 0.60–1.42, p = 0.518).
Conclusions:
Mediterranean diet may exert a protective influence regarding the risk of subsequently developing MS compared with Western-style diet.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>37366345</pmid><doi>10.1177/13524585231181841</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6612-4749</orcidid></addata></record> |
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| ispartof | Multiple sclerosis, 2023-08, Vol.29 (9), p.1118-1125 |
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| subjects | Alcohol Drinking Body mass index Case-Control Studies Diet Diet, Mediterranean Humans Inflammatory diseases Medicin och hälsovetenskap Multiple sclerosis Multiple Sclerosis - epidemiology Multiple Sclerosis - etiology Multiple Sclerosis - prevention & control Nutrient deficiency Physical activity Population studies Regression analysis Risk Factors Vegetarian diet Vegetarianism |
| title | Inverse association between Mediterranean diet and risk of multiple sclerosis |
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