Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers

Exercise training positively affects metabolic health through increased mitochondrial oxidative capacity and improved glucose regulation and is the first line of treatment in several metabolic diseases. However, the upper limit of the amount of exercise associated with beneficial therapeutic effects...

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Veröffentlicht in:	Cell metabolism 2021-05, Vol.33 (5), p.957-970.e6
Hauptverfasser:	Flockhart, Mikael, Nilsson, Lina C., Tais, Senna, Ekblom, Björn, Apró, William, Larsen, Filip J.
Format:	Artikel
Sprache:	eng
Schlagworte:	athletes Blood Glucose - analysis Catalase - metabolism continuous glucose monitoring exercise exercise adaptations glucose tolerance Glucose Tolerance Test Glucose Transporter Type 4 - metabolism Glycogen - metabolism Healthy Volunteers high-intensity interval training Humans Hydrogen Peroxide - metabolism insulin resistance Medicin/Teknik Medicine/Technology metabolic dysfunction mitochondria Mitochondria - metabolism mitochondrial dynamics mitochondrial dysfunction Muscle, Skeletal - metabolism Muscle, Skeletal - pathology NF-E2-Related Factor 2 - metabolism Oxidative Stress Physical Endurance Superoxide Dismutase - metabolism
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