Smoking affects epigenetic ageing of lung bronchoalveolar lavage cells in Multiple Sclerosis

•Epigenetic age estimations vary depending on which clock is used.•Lung BAL cells of pwMS display accelerated AltumAge epigenetic ageing compared to controls.•Faster AltumAge ageing in pwMS vs. controls could not be found in blood monocytes.•Smoking affects BAL epigenetic age in pwMS, specifically.•...

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Veröffentlicht in:	Multiple sclerosis and related disorders 2023-11, Vol.79, p.104991, Article 104991
Hauptverfasser:	Klose, Dennis, Needhamsen, Maria, Ringh, Mikael V., Hagemann-Jensen, Michael, Jagodic, Maja, Kular, Lara
Format:	Artikel
Sprache:	eng
Schlagworte:	Ageing DNA methylation Epigenetic clocks Inflammation Lung alveolar macrophages Multiple Sclerosis Smoking
Online-Zugang:	Volltext
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