High-throughput identification of regulatory elements and functional assays to uncover susceptibility genes for nasopharyngeal carcinoma

Large-scale genetic association studies have identified multiple susceptibility loci for nasopharyngeal carcinoma (NPC), but the underlying biological mechanisms remain to be explored. To gain insights into the genetic etiology of NPC, we conducted a follow-up study encompassing 6,907 cases and 10,4...

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Veröffentlicht in:	American journal of human genetics 2023-07, Vol.110 (7), p.1162-1176
Hauptverfasser:	Wang, Tong-Min, Xiao, Ruo-Wen, He, Yong-Qiao, Zhang, Wen-Li, Diao, Hua, Tang, Minzhong, Mai, Zhi-Ming, Xue, Wen-Qiong, Yang, Da-Wei, Deng, Chang-Mi, Liao, Ying, Zhou, Ting, Li, Dan-Hua, Wu, Yan-Xia, Chen, Xue-Yin, Zhang, Jiangbo, Li, Xi-Zhao, Zhang, Pei-Fen, Zheng, Xiao-Hui, Zhang, Shao-Dan, Hu, Ye-Zhu, Cai, Yonglin, Zheng, Yuming, Zhang, Zhe, Zhou, Yifeng, Jin, Guangfu, Bei, Jinxin, Mai, Hai-Qiang, Sun, Ying, Ma, Jun, Hu, Zhibin, Liu, Jianjun, Lung, Maria Li, Adami, Hans-Olov, Ye, Weimin, Lam, Tai-Hing, Shen, Hongbing, Jia, Wei-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	cis-regulatory elements Follow-Up Studies functional profiling Genetic Association Studies Genetic Predisposition to Disease genome-wide association study Homeodomain Proteins - genetics Humans nasopharyngeal carcinoma Nasopharyngeal Carcinoma - genetics Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - pathology Polymorphism, Single Nucleotide - genetics
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