Decrease of lethal infectious complications in the context of causes of death (COD) after hematopoietic cell transplantation: COD-2 and COD-1 study of the Infectious Diseases Working Party EBMT
We previously analyzed trends in incidence and factors associated with lethal complications in ALL/AML/CML patients (causes of deaths; COD-1 study). The objective of this study was the analysis of incidence and specific causes of death after HCT, with focus on infectious deaths in two time periods,...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2023-08, Vol.58 (8), p.881-892 |
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| creator | Styczynski, Jan Tridello, Gloria Koster, Linda Knelange, Nina Wendel, Lotus van Biezen, Anja van der Werf, Steffie Mikulska, Malgorzata Gil, Lidia Cordonnier, Catherine Ljungman, Per Averbuch, Diana Cesaro, Simone Baldomero, Helen Chabannon, Christian Corbacioglu, Selim Dolstra, Harry Glass, Bertram Greco, Raffaella Kröger, Nicolaus de Latour, Régis Peffault Mohty, Mohamad Neven, Benedicte Peric, Zinaida Snowden, John A. Sureda, Anna Yakoub-Agha, Ibrahim de la Camara, Rafael |
| description | We previously analyzed trends in incidence and factors associated with lethal complications in ALL/AML/CML patients (causes of deaths; COD-1 study). The objective of this study was the analysis of incidence and specific causes of death after HCT, with focus on infectious deaths in two time periods, 1980–2001 (cohort-1) and 2002–2015 (cohort-2). All patients with HCT for lymphoma, plasma cell disorders, chronic leukemia (except CML), myelodysplastic/myeloproliferative disorders, registered in the EBMT-ProMISe-database were included (
n
= 232,618) (COD-2 study). Results were compared to those in the ALL/AML/CML COD-1 study. Mortality from bacterial, viral, fungal, and parasitic infections decreased in very early, early and intermediate phases. In the late phase, mortality from bacterial infections increased, while mortality from fungal, viral, or unknown infectious etiology did not change. This pattern was similar for allo- and auto-HCT in COD-1 and COD-2 studies, with a distinct and constant lower incidence of all types of infections at all phases, after auto-HCT. In conclusion, infections were the main cause of death before day +100, followed by relapse. Mortality from infectious deaths significantly decreased, except late phase. Post-transplant mortality has significantly decreased in all phases, from all causes after auto-HCT; it has decreased in all phases after allo-HCT except late phase. |
| doi_str_mv | 10.1038/s41409-023-01998-2 |
| format | Article |
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n
= 232,618) (COD-2 study). Results were compared to those in the ALL/AML/CML COD-1 study. Mortality from bacterial, viral, fungal, and parasitic infections decreased in very early, early and intermediate phases. In the late phase, mortality from bacterial infections increased, while mortality from fungal, viral, or unknown infectious etiology did not change. This pattern was similar for allo- and auto-HCT in COD-1 and COD-2 studies, with a distinct and constant lower incidence of all types of infections at all phases, after auto-HCT. In conclusion, infections were the main cause of death before day +100, followed by relapse. Mortality from infectious deaths significantly decreased, except late phase. Post-transplant mortality has significantly decreased in all phases, from all causes after auto-HCT; it has decreased in all phases after allo-HCT except late phase.</description><identifier>ISSN: 0268-3369</identifier><identifier>EISSN: 1476-5365</identifier><identifier>DOI: 10.1038/s41409-023-01998-2</identifier><identifier>PMID: 37149673</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/174 ; 692/700/478/174 ; Acute myeloid leukemia ; Bacterial diseases ; Bacterial infections ; Cell Biology ; Cell death ; Complications ; Death ; Disorders ; Fatalities ; Fungi ; Hematology ; Hematopoietic stem cells ; Infections ; Infectious diseases ; Internal Medicine ; Leukemia ; Life Sciences ; Lymphoma ; Medicine ; Medicine & Public Health ; Mortality ; Myeloproliferative diseases ; Parasitic diseases ; Phases ; Public Health ; Stem cell transplantation ; Stem Cells ; Transplantation ; Transplants & implants</subject><ispartof>Bone marrow transplantation (Basingstoke), 2023-08, Vol.58 (8), p.881-892</ispartof><rights>The Author(s), under exclusive licence to Springer Nature Limited 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer Nature Limited.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-970489ed5a029b1ef37db7ac456c163323f58be3dc038e985a60ca54955a30e63</citedby><cites>FETCH-LOGICAL-c447t-970489ed5a029b1ef37db7ac456c163323f58be3dc038e985a60ca54955a30e63</cites><orcidid>0000-0001-9458-8025 ; 0000-0002-6554-483X ; 0000-0002-3158-119X ; 0000-0002-5535-4602 ; 0000-0002-7264-808X ; 0000-0002-3755-4889 ; 0000-0002-8698-9547 ; 0000-0002-8189-5779 ; 0000-0002-8281-3245 ; 0000-0002-6117-5328 ; 0000-0003-4524-8782</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41409-023-01998-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41409-023-01998-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37149673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.univ-lille.fr/hal-04491564$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:152580587$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Styczynski, Jan</creatorcontrib><creatorcontrib>Tridello, Gloria</creatorcontrib><creatorcontrib>Koster, Linda</creatorcontrib><creatorcontrib>Knelange, Nina</creatorcontrib><creatorcontrib>Wendel, Lotus</creatorcontrib><creatorcontrib>van Biezen, Anja</creatorcontrib><creatorcontrib>van der Werf, Steffie</creatorcontrib><creatorcontrib>Mikulska, Malgorzata</creatorcontrib><creatorcontrib>Gil, Lidia</creatorcontrib><creatorcontrib>Cordonnier, Catherine</creatorcontrib><creatorcontrib>Ljungman, Per</creatorcontrib><creatorcontrib>Averbuch, Diana</creatorcontrib><creatorcontrib>Cesaro, Simone</creatorcontrib><creatorcontrib>Baldomero, Helen</creatorcontrib><creatorcontrib>Chabannon, Christian</creatorcontrib><creatorcontrib>Corbacioglu, Selim</creatorcontrib><creatorcontrib>Dolstra, Harry</creatorcontrib><creatorcontrib>Glass, Bertram</creatorcontrib><creatorcontrib>Greco, Raffaella</creatorcontrib><creatorcontrib>Kröger, Nicolaus</creatorcontrib><creatorcontrib>de Latour, Régis Peffault</creatorcontrib><creatorcontrib>Mohty, Mohamad</creatorcontrib><creatorcontrib>Neven, Benedicte</creatorcontrib><creatorcontrib>Peric, Zinaida</creatorcontrib><creatorcontrib>Snowden, John A.</creatorcontrib><creatorcontrib>Sureda, Anna</creatorcontrib><creatorcontrib>Yakoub-Agha, Ibrahim</creatorcontrib><creatorcontrib>de la Camara, Rafael</creatorcontrib><title>Decrease of lethal infectious complications in the context of causes of death (COD) after hematopoietic cell transplantation: COD-2 and COD-1 study of the Infectious Diseases Working Party EBMT</title><title>Bone marrow transplantation (Basingstoke)</title><addtitle>Bone Marrow Transplant</addtitle><addtitle>Bone Marrow Transplant</addtitle><description>We previously analyzed trends in incidence and factors associated with lethal complications in ALL/AML/CML patients (causes of deaths; COD-1 study). The objective of this study was the analysis of incidence and specific causes of death after HCT, with focus on infectious deaths in two time periods, 1980–2001 (cohort-1) and 2002–2015 (cohort-2). All patients with HCT for lymphoma, plasma cell disorders, chronic leukemia (except CML), myelodysplastic/myeloproliferative disorders, registered in the EBMT-ProMISe-database were included (
n
= 232,618) (COD-2 study). Results were compared to those in the ALL/AML/CML COD-1 study. Mortality from bacterial, viral, fungal, and parasitic infections decreased in very early, early and intermediate phases. In the late phase, mortality from bacterial infections increased, while mortality from fungal, viral, or unknown infectious etiology did not change. This pattern was similar for allo- and auto-HCT in COD-1 and COD-2 studies, with a distinct and constant lower incidence of all types of infections at all phases, after auto-HCT. In conclusion, infections were the main cause of death before day +100, followed by relapse. Mortality from infectious deaths significantly decreased, except late phase. Post-transplant mortality has significantly decreased in all phases, from all causes after auto-HCT; it has decreased in all phases after allo-HCT except late phase.</description><subject>692/308/174</subject><subject>692/700/478/174</subject><subject>Acute myeloid leukemia</subject><subject>Bacterial diseases</subject><subject>Bacterial infections</subject><subject>Cell Biology</subject><subject>Cell death</subject><subject>Complications</subject><subject>Death</subject><subject>Disorders</subject><subject>Fatalities</subject><subject>Fungi</subject><subject>Hematology</subject><subject>Hematopoietic stem cells</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Internal Medicine</subject><subject>Leukemia</subject><subject>Life Sciences</subject><subject>Lymphoma</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Myeloproliferative diseases</subject><subject>Parasitic diseases</subject><subject>Phases</subject><subject>Public Health</subject><subject>Stem cell transplantation</subject><subject>Stem Cells</subject><subject>Transplantation</subject><subject>Transplants & 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Edition</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Bone marrow transplantation (Basingstoke)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Styczynski, Jan</au><au>Tridello, Gloria</au><au>Koster, Linda</au><au>Knelange, Nina</au><au>Wendel, Lotus</au><au>van Biezen, Anja</au><au>van der Werf, Steffie</au><au>Mikulska, Malgorzata</au><au>Gil, Lidia</au><au>Cordonnier, Catherine</au><au>Ljungman, Per</au><au>Averbuch, Diana</au><au>Cesaro, Simone</au><au>Baldomero, Helen</au><au>Chabannon, Christian</au><au>Corbacioglu, Selim</au><au>Dolstra, Harry</au><au>Glass, Bertram</au><au>Greco, Raffaella</au><au>Kröger, Nicolaus</au><au>de Latour, Régis Peffault</au><au>Mohty, Mohamad</au><au>Neven, Benedicte</au><au>Peric, Zinaida</au><au>Snowden, John A.</au><au>Sureda, Anna</au><au>Yakoub-Agha, Ibrahim</au><au>de la Camara, Rafael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decrease of lethal infectious complications in the context of causes of death (COD) after hematopoietic cell transplantation: COD-2 and COD-1 study of the Infectious Diseases Working Party EBMT</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><stitle>Bone Marrow Transplant</stitle><addtitle>Bone Marrow Transplant</addtitle><date>2023-08-01</date><risdate>2023</risdate><volume>58</volume><issue>8</issue><spage>881</spage><epage>892</epage><pages>881-892</pages><issn>0268-3369</issn><eissn>1476-5365</eissn><abstract>We previously analyzed trends in incidence and factors associated with lethal complications in ALL/AML/CML patients (causes of deaths; COD-1 study). The objective of this study was the analysis of incidence and specific causes of death after HCT, with focus on infectious deaths in two time periods, 1980–2001 (cohort-1) and 2002–2015 (cohort-2). All patients with HCT for lymphoma, plasma cell disorders, chronic leukemia (except CML), myelodysplastic/myeloproliferative disorders, registered in the EBMT-ProMISe-database were included (
n
= 232,618) (COD-2 study). Results were compared to those in the ALL/AML/CML COD-1 study. Mortality from bacterial, viral, fungal, and parasitic infections decreased in very early, early and intermediate phases. In the late phase, mortality from bacterial infections increased, while mortality from fungal, viral, or unknown infectious etiology did not change. This pattern was similar for allo- and auto-HCT in COD-1 and COD-2 studies, with a distinct and constant lower incidence of all types of infections at all phases, after auto-HCT. In conclusion, infections were the main cause of death before day +100, followed by relapse. Mortality from infectious deaths significantly decreased, except late phase. Post-transplant mortality has significantly decreased in all phases, from all causes after auto-HCT; it has decreased in all phases after allo-HCT except late phase.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>37149673</pmid><doi>10.1038/s41409-023-01998-2</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-9458-8025</orcidid><orcidid>https://orcid.org/0000-0002-6554-483X</orcidid><orcidid>https://orcid.org/0000-0002-3158-119X</orcidid><orcidid>https://orcid.org/0000-0002-5535-4602</orcidid><orcidid>https://orcid.org/0000-0002-7264-808X</orcidid><orcidid>https://orcid.org/0000-0002-3755-4889</orcidid><orcidid>https://orcid.org/0000-0002-8698-9547</orcidid><orcidid>https://orcid.org/0000-0002-8189-5779</orcidid><orcidid>https://orcid.org/0000-0002-8281-3245</orcidid><orcidid>https://orcid.org/0000-0002-6117-5328</orcidid><orcidid>https://orcid.org/0000-0003-4524-8782</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2023-08, Vol.58 (8), p.881-892 |
| issn | 0268-3369 1476-5365 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_628570 |
| source | EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | 692/308/174 692/700/478/174 Acute myeloid leukemia Bacterial diseases Bacterial infections Cell Biology Cell death Complications Death Disorders Fatalities Fungi Hematology Hematopoietic stem cells Infections Infectious diseases Internal Medicine Leukemia Life Sciences Lymphoma Medicine Medicine & Public Health Mortality Myeloproliferative diseases Parasitic diseases Phases Public Health Stem cell transplantation Stem Cells Transplantation Transplants & implants |
| title | Decrease of lethal infectious complications in the context of causes of death (COD) after hematopoietic cell transplantation: COD-2 and COD-1 study of the Infectious Diseases Working Party EBMT |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T05%3A55%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Decrease%20of%20lethal%20infectious%20complications%20in%20the%20context%20of%20causes%20of%20death%20(COD)%20after%20hematopoietic%20cell%20transplantation:%20COD-2%20and%20COD-1%20study%20of%20the%20Infectious%20Diseases%20Working%20Party%20EBMT&rft.jtitle=Bone%20marrow%20transplantation%20(Basingstoke)&rft.au=Styczynski,%20Jan&rft.date=2023-08-01&rft.volume=58&rft.issue=8&rft.spage=881&rft.epage=892&rft.pages=881-892&rft.issn=0268-3369&rft.eissn=1476-5365&rft_id=info:doi/10.1038/s41409-023-01998-2&rft_dat=%3Cproquest_swepu%3E2845354695%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2845354695&rft_id=info:pmid/37149673&rfr_iscdi=true |