Disorganized sleep-wake schedule associated with neuroendocrine abnormalities in dementia. A clinical study
Demented patients were investigated by blood sampling at 10 occasions during a 24‐hour period. Serum levels of melatonin and cortisol were determined. One patient with probable vascular dementia had a severely disorganized sleep‐wake schedule and showed disturbed patterns of serum melatonin and cort...
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| Veröffentlicht in: | International journal of geriatric psychiatry 1995-02, Vol.10 (2), p.107-113 |
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| container_title | International journal of geriatric psychiatry |
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| creator | Björkstén, Karin Sparring Basun, Hans Wetterberg, Lennart |
| description | Demented patients were investigated by blood sampling at 10 occasions during a 24‐hour period. Serum levels of melatonin and cortisol were determined. One patient with probable vascular dementia had a severely disorganized sleep‐wake schedule and showed disturbed patterns of serum melatonin and cortisol. After withdrawal of alprenolol, substitution of a vitamin B12 deficiency and cataract surgery, the patient regained normal sleep habits and a normal circadian pattern of serum cortisol and melatonin. A patient with frontal lobe dementia and a disorganized sleep‐wake schedule showed a disturbed melatonin rhythm, unexpected cortisol peaks and a disability to suppress melatonin by light. Two Alzheimer patients with regular sleep habits had normal circadian patterns of serum melatonin and cortisol. |
| doi_str_mv | 10.1002/gps.930100205 |
| format | Article |
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A clinical study</title><title>International journal of geriatric psychiatry</title><addtitle>Int. J. Geriat. Psychiatry</addtitle><description>Demented patients were investigated by blood sampling at 10 occasions during a 24‐hour period. Serum levels of melatonin and cortisol were determined. One patient with probable vascular dementia had a severely disorganized sleep‐wake schedule and showed disturbed patterns of serum melatonin and cortisol. After withdrawal of alprenolol, substitution of a vitamin B12 deficiency and cataract surgery, the patient regained normal sleep habits and a normal circadian pattern of serum cortisol and melatonin. A patient with frontal lobe dementia and a disorganized sleep‐wake schedule showed a disturbed melatonin rhythm, unexpected cortisol peaks and a disability to suppress melatonin by light. Two Alzheimer patients with regular sleep habits had normal circadian patterns of serum melatonin and cortisol.</description><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>dementia</subject><subject>Disorganized sleep-wake schedule</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>serum cortisol</subject><subject>serum melatonin</subject><subject>vitamin B12</subject><issn>0885-6230</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><recordid>eNp9kUFv1DAQhS0EEkvLsfccELcsdhwn9rFa6BapgkoF0Zvl2JPWbNYOnkTb5dfjalcLJ04zmvfms_WGkAtGl4zS6sPDiEvF6XNPxQuyYFSpkrGmeUkWVEpRNhWnr8kbxJ-UZo3JBdl89BjTgwn-N7gCB4Cx3JkNFGgfwc0DFAYxWm-mLO_89FgEmFOE4KJNPmS5CzFtzeAnD1j4UDjYQpi8WRaXhR188NYMBU6z25-TV70ZEN4e6xn5fvXp2-q6vPm6_ry6vCltzZQopTBGyVoZ13AlnarrXnJn-762jPe256K2He9ULcAxIVvRmLp3SjCnoKuU42ekPHBxB-Pc6TH5rUl7HY3Xx9Emd6AbJkRLs__9wT-m-GsGnPTWo4VhMAHijLpiOcmKyb9gmyJigv6EZlQ_x67zCfTpBNn_7gg2mFPokwnW42mJc9VyybOtPdh2foD9_5l6fXv37wPHD3mc4Om0adJGNy1vhf7xZa3X11f3d7JmesX_AJ4zqJo</recordid><startdate>199502</startdate><enddate>199502</enddate><creator>Björkstén, Karin Sparring</creator><creator>Basun, Hans</creator><creator>Wetterberg, Lennart</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>199502</creationdate><title>Disorganized sleep-wake schedule associated with neuroendocrine abnormalities in dementia. 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Prion diseases</topic><topic>dementia</topic><topic>Disorganized sleep-wake schedule</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>serum cortisol</topic><topic>serum melatonin</topic><topic>vitamin B12</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Björkstén, Karin Sparring</creatorcontrib><creatorcontrib>Basun, Hans</creatorcontrib><creatorcontrib>Wetterberg, Lennart</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Björkstén, Karin Sparring</au><au>Basun, Hans</au><au>Wetterberg, Lennart</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Disorganized sleep-wake schedule associated with neuroendocrine abnormalities in dementia. 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| identifier | ISSN: 0885-6230 |
| ispartof | International journal of geriatric psychiatry, 1995-02, Vol.10 (2), p.107-113 |
| issn | 0885-6230 1099-1166 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_615570 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases dementia Disorganized sleep-wake schedule Medical sciences Neurology serum cortisol serum melatonin vitamin B12 |
| title | Disorganized sleep-wake schedule associated with neuroendocrine abnormalities in dementia. A clinical study |
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