Effects of intrathecal orphanin FQ on a flexor reflex in the rat after inflammation or peripheral nerve section

We examined the effects of intrathecal orphanin FQ, the endogenous ligand for the orphan opioid-like receptor, on the hamstring nociceptive flexor reflex in decerebrate, spinalized, unanesthetized rats after carrageenan-induced inflammation or unilateral sciatic nerve transection. As described previ...

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Veröffentlicht in:	European journal of pharmacology 1999-04, Vol.370 (1), p.17-22
Hauptverfasser:	Xu, Isabella S, Grass, Stefan, Wiesenfeld-Hallin, Zsuzsanna, Xu, Xiao-Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antinociception Biological and medical sciences Carrageenan Dose-Response Relationship, Drug Excipients Female Fundamental and applied biological sciences. Psychology Inflammation - chemically induced Injections, Spinal Muscle, Skeletal - drug effects Nerve injury Neuropathic pain Nociceptin Opioid Opioid Peptides - administration & dosage Opioid Peptides - pharmacology Pain - drug therapy Rats Rats, Sprague-Dawley Reflex - drug effects Regression Analysis Sciatic Nerve - injuries Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal cord Spinal Cord - drug effects Vertebrates: nervous system and sense organs
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