Stimulation of fecal steroid excretion after infusion of recombinant proapolipoprotein A-I: Potential reverse cholesterol transport in humans

Apolipoprotein (apo) A-I is the major protein component of HDL, a cholesterol transport particle that protects against atherosclerosis. Apo A-I is believed to promote reverse cholesterol transport, transferring cholesterol from peripheral cells to the liver for subsequent elimination. To test this h...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 1999-08, Vol.100 (6), p.594-598
Hauptverfasser:	ERIKSSON, M, CARLSON, L. A, MIETTINEN, T. A, ANGELIN, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Apolipoprotein A-I - blood Apolipoprotein A-I - genetics Apolipoproteins A - administration & dosage Apolipoproteins A - pharmacology Apolipoproteins A - therapeutic use Arteriosclerosis - drug therapy Bile Acids and Salts - analysis Biological and medical sciences Biological Transport - drug effects Biomarkers Cholesterol - blood Cholesterol, HDL - blood Coronary Artery Disease - drug therapy Coronary Artery Disease - metabolism Drug Evaluation Feces - chemistry General and cellular metabolism. Vitamins Heterozygote Humans Hyperlipoproteinemia Type II - complications Hyperlipoproteinemia Type II - drug therapy Hyperlipoproteinemia Type II - genetics Hyperlipoproteinemia Type II - metabolism Infusions, Intravenous Liposomes - administration & dosage Liposomes - therapeutic use Liver - metabolism Male Medical sciences Middle Aged Pharmacology. Drug treatments Phospholipids - administration & dosage Protein Precursors - administration & dosage Protein Precursors - pharmacology Protein Precursors - therapeutic use Recombinant Fusion Proteins - administration & dosage Recombinant Fusion Proteins - therapeutic use Sterols - analysis
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