Perforin is not co-expressed with granzyme A within cytotoxic granules in CD8 T lymphocytes present in lymphoid tissue during chronic HIV infection

Residual HIV-1-infected cells are poorly eliminated from lymphoid tissue (LT) reservoirs by effector cytotoxic T lymphocytes (eCTL) despite antiretroviral therapy. Perforin and granzyme A (grA) constitute major effector molecules within eCTL granules that induce apoptosis and lysis of virally infect...

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Veröffentlicht in:	AIDS (London) 1999-07, Vol.13 (11), p.1295-1303
Hauptverfasser:	ANDERSSON, J, BEHBAHANI, H, LIEBERMAN, J, CONNICK, E, LANDAY, A, PATTERSON, B, SÖNNERBORG, A, LORE, K, UCCINI, S, FEHNIGER, T. E
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Biological and medical sciences CD4 Lymphocyte Count CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cytoplasmic Granules - metabolism Granzymes HIV Infections - immunology HIV-1 - physiology Human immunodeficiency virus 1 Human viral diseases Humans Image Processing, Computer-Assisted Immunohistochemistry Infectious diseases Lymph Nodes - immunology Lymphoid Tissue - immunology Medical sciences Membrane Glycoproteins - metabolism Palatine Tonsil - immunology Perforin Pore Forming Cytotoxic Proteins RNA, Viral - blood Serine Endopeptidases - metabolism T-Lymphocytes, Cytotoxic - immunology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids
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