A Behavioral Analysis of the Spatial Learning Deficit Induced by the NMDA Receptor Antagonist MK-801 (Dizocilpine) in the Rat
This study analyzes whether the disruptive effects of the noncompetitive NMDA receptor antagonist MK-801 (0.01– 0.1 mg/kg SC) on spatial learning can be dissociated from sensorimotor disturbances in the rat. Two different modifications of the Morris swim maze task with a hidden underwater platform w...
Gespeichert in:
| Veröffentlicht in: | Neuropsychopharmacology (New York, N.Y.) N.Y.), 1999-09, Vol.21 (3), p.414-426 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 426 |
|---|---|
| container_issue | 3 |
| container_start_page | 414 |
| container_title | Neuropsychopharmacology (New York, N.Y.) |
| container_volume | 21 |
| creator | Åhlander, Maria Misane, Ilga Schött, Pär A Ögren, Sven Ove |
| description | This study analyzes whether the disruptive effects of the noncompetitive NMDA receptor antagonist MK-801 (0.01– 0.1 mg/kg SC) on spatial learning can be dissociated from sensorimotor disturbances in the rat. Two different modifications of the Morris swim maze task with a hidden underwater platform were used: with or without local cue. Retention was tested either 24 h or 7 days after training as a probe trial (without platform). The present data indicate that MK-801 produces an impairment of spatial learning that cannot be dissociated from motor or sensory mechanisms. These findings support the view that NMDA receptors probably contribute to, but are not essential for, spatial learning in the water maze. |
| doi_str_mv | 10.1016/S0893-133X(98)00116-X |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_604486</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0893133X9800116X</els_id><sourcerecordid>69986921</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-f0cd4da3690e3894d22d4f3a90c038da904a34e9336d91b130b0dfadef1fc2de3</originalsourceid><addsrcrecordid>eNqFkV1vFCEUhonR2G31J2i4MKa9GIWFYYYrs3b9aNxq0mqyd4SBMy06O4zAtFkT_7t0Z1O98-qQk-d9ITwIPaPkFSVUvL4ktWQFZWx9LOsTQigVxfoBmtGKk0Iwvn6IZvfIATqM8XuGykrUj9EBJbysSiZn6PcCv4VrfeN80B1e9LrbRhexb3G6Bnw56OTyfgU69K6_wktonXEJn_V2NGBxs91xn8-XC3wBBobkQ25J-sr3LiZ8_qmoCcXHS_fLG9cNrocT7Ppd6EKnJ-hRq7sIT_fzCH17_-7r6cdi9eXD2eliVRhelaloibHcaiYkAVZLbudzy1umJTGE1TZPrhkHyZiwkjaUkYbYVltoaWvmFtgRKqbeeAvD2KghuI0OW-W1U_vVj3wCJQjntcj8y4kfgv85Qkxq46KBrtM9-DEqIWUt5JxmsJxAE3yMAdr7akrUnSe186TuJChZq50ntc655_sLxmYD9p_UJCYDL_aAjkZ3bdC9cfEvJwlhrMrYmwmD_Hs3DoKKxkGf1bgAJinr3X9e8gdW9K_P</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69986921</pqid></control><display><type>article</type><title>A Behavioral Analysis of the Spatial Learning Deficit Induced by the NMDA Receptor Antagonist MK-801 (Dizocilpine) in the Rat</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Åhlander, Maria ; Misane, Ilga ; Schött, Pär A ; Ögren, Sven Ove</creator><creatorcontrib>Åhlander, Maria ; Misane, Ilga ; Schött, Pär A ; Ögren, Sven Ove</creatorcontrib><description>This study analyzes whether the disruptive effects of the noncompetitive NMDA receptor antagonist MK-801 (0.01– 0.1 mg/kg SC) on spatial learning can be dissociated from sensorimotor disturbances in the rat. Two different modifications of the Morris swim maze task with a hidden underwater platform were used: with or without local cue. Retention was tested either 24 h or 7 days after training as a probe trial (without platform). The present data indicate that MK-801 produces an impairment of spatial learning that cannot be dissociated from motor or sensory mechanisms. These findings support the view that NMDA receptors probably contribute to, but are not essential for, spatial learning in the water maze.</description><identifier>ISSN: 0893-133X</identifier><identifier>EISSN: 1740-634X</identifier><identifier>DOI: 10.1016/S0893-133X(98)00116-X</identifier><identifier>PMID: 10457539</identifier><identifier>CODEN: NEROEW</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Behavior, Animal - drug effects ; Biological and medical sciences ; Cued platform ; Dizocilpine Maleate - pharmacology ; Excitatory Amino Acid Antagonists - pharmacology ; Glutamatergic system (aspartate and other excitatory aminoacids) ; Hidden platform ; Hippocampus ; Male ; Maze Learning - drug effects ; Medical sciences ; MK-801 ; Motor performance ; Neuropharmacology ; Neurotransmitters. Neurotransmission. Receptors ; NMDA receptors ; Pharmacology. Drug treatments ; Psychomotor Performance - drug effects ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors ; Retention (Psychology) - drug effects ; Sensory processing ; Spatial learning</subject><ispartof>Neuropsychopharmacology (New York, N.Y.), 1999-09, Vol.21 (3), p.414-426</ispartof><rights>1999 American College of Neuropsychopharmacology</rights><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-f0cd4da3690e3894d22d4f3a90c038da904a34e9336d91b130b0dfadef1fc2de3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1900337$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10457539$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1957919$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Åhlander, Maria</creatorcontrib><creatorcontrib>Misane, Ilga</creatorcontrib><creatorcontrib>Schött, Pär A</creatorcontrib><creatorcontrib>Ögren, Sven Ove</creatorcontrib><title>A Behavioral Analysis of the Spatial Learning Deficit Induced by the NMDA Receptor Antagonist MK-801 (Dizocilpine) in the Rat</title><title>Neuropsychopharmacology (New York, N.Y.)</title><addtitle>Neuropsychopharmacology</addtitle><description>This study analyzes whether the disruptive effects of the noncompetitive NMDA receptor antagonist MK-801 (0.01– 0.1 mg/kg SC) on spatial learning can be dissociated from sensorimotor disturbances in the rat. Two different modifications of the Morris swim maze task with a hidden underwater platform were used: with or without local cue. Retention was tested either 24 h or 7 days after training as a probe trial (without platform). The present data indicate that MK-801 produces an impairment of spatial learning that cannot be dissociated from motor or sensory mechanisms. These findings support the view that NMDA receptors probably contribute to, but are not essential for, spatial learning in the water maze.</description><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Biological and medical sciences</subject><subject>Cued platform</subject><subject>Dizocilpine Maleate - pharmacology</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Glutamatergic system (aspartate and other excitatory aminoacids)</subject><subject>Hidden platform</subject><subject>Hippocampus</subject><subject>Male</subject><subject>Maze Learning - drug effects</subject><subject>Medical sciences</subject><subject>MK-801</subject><subject>Motor performance</subject><subject>Neuropharmacology</subject><subject>Neurotransmitters. Neurotransmission. Receptors</subject><subject>NMDA receptors</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychomotor Performance - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</subject><subject>Retention (Psychology) - drug effects</subject><subject>Sensory processing</subject><subject>Spatial learning</subject><issn>0893-133X</issn><issn>1740-634X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1vFCEUhonR2G31J2i4MKa9GIWFYYYrs3b9aNxq0mqyd4SBMy06O4zAtFkT_7t0Z1O98-qQk-d9ITwIPaPkFSVUvL4ktWQFZWx9LOsTQigVxfoBmtGKk0Iwvn6IZvfIATqM8XuGykrUj9EBJbysSiZn6PcCv4VrfeN80B1e9LrbRhexb3G6Bnw56OTyfgU69K6_wktonXEJn_V2NGBxs91xn8-XC3wBBobkQ25J-sr3LiZ8_qmoCcXHS_fLG9cNrocT7Ppd6EKnJ-hRq7sIT_fzCH17_-7r6cdi9eXD2eliVRhelaloibHcaiYkAVZLbudzy1umJTGE1TZPrhkHyZiwkjaUkYbYVltoaWvmFtgRKqbeeAvD2KghuI0OW-W1U_vVj3wCJQjntcj8y4kfgv85Qkxq46KBrtM9-DEqIWUt5JxmsJxAE3yMAdr7akrUnSe186TuJChZq50ntc655_sLxmYD9p_UJCYDL_aAjkZ3bdC9cfEvJwlhrMrYmwmD_Hs3DoKKxkGf1bgAJinr3X9e8gdW9K_P</recordid><startdate>19990901</startdate><enddate>19990901</enddate><creator>Åhlander, Maria</creator><creator>Misane, Ilga</creator><creator>Schött, Pär A</creator><creator>Ögren, Sven Ove</creator><general>Elsevier Inc</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>19990901</creationdate><title>A Behavioral Analysis of the Spatial Learning Deficit Induced by the NMDA Receptor Antagonist MK-801 (Dizocilpine) in the Rat</title><author>Åhlander, Maria ; Misane, Ilga ; Schött, Pär A ; Ögren, Sven Ove</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-f0cd4da3690e3894d22d4f3a90c038da904a34e9336d91b130b0dfadef1fc2de3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Biological and medical sciences</topic><topic>Cued platform</topic><topic>Dizocilpine Maleate - pharmacology</topic><topic>Excitatory Amino Acid Antagonists - pharmacology</topic><topic>Glutamatergic system (aspartate and other excitatory aminoacids)</topic><topic>Hidden platform</topic><topic>Hippocampus</topic><topic>Male</topic><topic>Maze Learning - drug effects</topic><topic>Medical sciences</topic><topic>MK-801</topic><topic>Motor performance</topic><topic>Neuropharmacology</topic><topic>Neurotransmitters. Neurotransmission. Receptors</topic><topic>NMDA receptors</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychomotor Performance - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</topic><topic>Retention (Psychology) - drug effects</topic><topic>Sensory processing</topic><topic>Spatial learning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Åhlander, Maria</creatorcontrib><creatorcontrib>Misane, Ilga</creatorcontrib><creatorcontrib>Schött, Pär A</creatorcontrib><creatorcontrib>Ögren, Sven Ove</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Åhlander, Maria</au><au>Misane, Ilga</au><au>Schött, Pär A</au><au>Ögren, Sven Ove</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Behavioral Analysis of the Spatial Learning Deficit Induced by the NMDA Receptor Antagonist MK-801 (Dizocilpine) in the Rat</atitle><jtitle>Neuropsychopharmacology (New York, N.Y.)</jtitle><addtitle>Neuropsychopharmacology</addtitle><date>1999-09-01</date><risdate>1999</risdate><volume>21</volume><issue>3</issue><spage>414</spage><epage>426</epage><pages>414-426</pages><issn>0893-133X</issn><eissn>1740-634X</eissn><coden>NEROEW</coden><abstract>This study analyzes whether the disruptive effects of the noncompetitive NMDA receptor antagonist MK-801 (0.01– 0.1 mg/kg SC) on spatial learning can be dissociated from sensorimotor disturbances in the rat. Two different modifications of the Morris swim maze task with a hidden underwater platform were used: with or without local cue. Retention was tested either 24 h or 7 days after training as a probe trial (without platform). The present data indicate that MK-801 produces an impairment of spatial learning that cannot be dissociated from motor or sensory mechanisms. These findings support the view that NMDA receptors probably contribute to, but are not essential for, spatial learning in the water maze.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>10457539</pmid><doi>10.1016/S0893-133X(98)00116-X</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0893-133X |
| ispartof | Neuropsychopharmacology (New York, N.Y.), 1999-09, Vol.21 (3), p.414-426 |
| issn | 0893-133X 1740-634X |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_604486 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Behavior, Animal - drug effects Biological and medical sciences Cued platform Dizocilpine Maleate - pharmacology Excitatory Amino Acid Antagonists - pharmacology Glutamatergic system (aspartate and other excitatory aminoacids) Hidden platform Hippocampus Male Maze Learning - drug effects Medical sciences MK-801 Motor performance Neuropharmacology Neurotransmitters. Neurotransmission. Receptors NMDA receptors Pharmacology. Drug treatments Psychomotor Performance - drug effects Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Retention (Psychology) - drug effects Sensory processing Spatial learning |
| title | A Behavioral Analysis of the Spatial Learning Deficit Induced by the NMDA Receptor Antagonist MK-801 (Dizocilpine) in the Rat |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T23%3A05%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20Behavioral%20Analysis%20of%20the%20Spatial%20Learning%20Deficit%20Induced%20by%20the%20NMDA%20Receptor%20Antagonist%20MK-801%20(Dizocilpine)%20in%20the%20Rat&rft.jtitle=Neuropsychopharmacology%20(New%20York,%20N.Y.)&rft.au=%C3%85hlander,%20Maria&rft.date=1999-09-01&rft.volume=21&rft.issue=3&rft.spage=414&rft.epage=426&rft.pages=414-426&rft.issn=0893-133X&rft.eissn=1740-634X&rft.coden=NEROEW&rft_id=info:doi/10.1016/S0893-133X(98)00116-X&rft_dat=%3Cproquest_swepu%3E69986921%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=69986921&rft_id=info:pmid/10457539&rft_els_id=S0893133X9800116X&rfr_iscdi=true |