Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum (II)

The thioredoxin (TRX) system, composed of nicotinamide adenine dinucleotide phosphate (reduced form), TRX, and TRX reductase (TRXR), has multiple biologic functions via thiol-mediated redox control. In this study, we investigated the relationship between intracellular TRXR levels and cellular sensit...

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Veröffentlicht in:	Free radical biology & medicine 1999-09, Vol.27 (5), p.504-514
Hauptverfasser:	Sasada, Tetsuro, Nakamura, Hajime, Ueda, Shugo, Sato, Norihito, Kitaoka, Yuki, Gon, Yasuhiro, Takabayashi, Arimichi, Spyrou, Giannis, Holmgren, Arne, Yodoi, Junji
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Cell Survival - drug effects cis-Diamminedichloroplatinum (II) Cisplatin - pharmacology Cytotoxicity Doxorubicin - pharmacology Drug Resistance - genetics Enzyme Inhibitors - pharmacology Free radicals HeLa Cells Humans Hydrogen Peroxide - pharmacology Kinetics Redox RNA, Antisense - pharmacology RNA, Messenger - metabolism Selenic Acid Selenium Compounds - pharmacology Thioredoxin Thioredoxin reductase Thioredoxin-Disulfide Reductase - metabolism Thioredoxins - metabolism Transfection
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