Exclusion of dominant mutations within the FTDP-17 locus on chromosome 17 for Parkinson's disease
Parkinson's disease (PD) is a prevalent movement disorder, and 10-30% of PD is familial. Several neurodegenerative disorders which are collectively called frontotemporal dementia and parkinsonism have been mapped to chromosome 17q and mutations in tau have been identified. The clinical and path...
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| Veröffentlicht in: | Neuroscience letters 1999-09, Vol.272 (2), p.140-142 |
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| container_title | Neuroscience letters |
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| creator | ZAREPARSI, S WIRDEFELDT, K BURGESS, C. E NUTT, J KRAMER, P SCHALLING, M PAYAMI, H |
| description | Parkinson's disease (PD) is a prevalent movement disorder, and 10-30% of PD is familial. Several neurodegenerative disorders which are collectively called frontotemporal dementia and parkinsonism have been mapped to chromosome 17q and mutations in tau have been identified. The clinical and pathological overlap suggests that these related conditions may be due to mutations in tau. We examined linkage to the candidate region on chromosome 17 including and surrounding tau in eight familial PD kindreds. We found no evidence for linkage and excluded the 6cM candidate region which suggest that in our families, PD is not caused by dominant mutations within tau. |
| doi_str_mv | 10.1016/S0304-3940(99)00581-9 |
| format | Article |
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We found no evidence for linkage and excluded the 6cM candidate region which suggest that in our families, PD is not caused by dominant mutations within tau.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>chromosome 17</subject><subject>Chromosomes, Human, Pair 17 - genetics</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Genetic Linkage - genetics</subject><subject>Genotype</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mutation - genetics</subject><subject>Neurology</subject><subject>Parkinson Disease - genetics</subject><subject>tau Proteins - genetics</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1999</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAURi0EokPhEUBeIKCLgK9_4niJSguVKlGJsrY8jq0xTeLBN1Hp2-PpjAq7rnz16XzXtg4hr4F9BAbtpx9MMNkII9kHY04YUx005glZQad5o43mT8nqATkiLxB_sUqBks_JETDFtGphRdzZHz8smPJEc6R9HtPkppmOy-zmGiK9TfMmTXTeBHp-_eWqAU2H7BekteE3JY8Z8xhojWMu9MqVmzRhnt4j7RMGh-EleRbdgOHV4TwmP8_Prk-_NZffv16cfr5svGRiblrueeCqM2vvjOBCSG-45oKvI0TGe91xKYKHtlei15GFKKWEXoteRAFOiWPS7Pfibdgua7staXTlzmaX7CG6qVOwLZNMQ-Xf7fltyb-XgLMdE_owDG4KeUGrme6UBvUoCLp-AKSpoNqDvmTEEuLDG4DZnTR7L83ujFhj7L00u-u9OVywrMfQ_9faW6rA2wPg0LshFjf5hP84ozotQfwFsieePA</recordid><startdate>19990910</startdate><enddate>19990910</enddate><creator>ZAREPARSI, S</creator><creator>WIRDEFELDT, K</creator><creator>BURGESS, C. 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Prion diseases</topic><topic>Genetic Linkage - genetics</topic><topic>Genotype</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mutation - genetics</topic><topic>Neurology</topic><topic>Parkinson Disease - genetics</topic><topic>tau Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZAREPARSI, S</creatorcontrib><creatorcontrib>WIRDEFELDT, K</creatorcontrib><creatorcontrib>BURGESS, C. 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| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1999-09, Vol.272 (2), p.140-142 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences chromosome 17 Chromosomes, Human, Pair 17 - genetics Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Genetic Linkage - genetics Genotype Humans Medical sciences Middle Aged Mutation - genetics Neurology Parkinson Disease - genetics tau Proteins - genetics |
| title | Exclusion of dominant mutations within the FTDP-17 locus on chromosome 17 for Parkinson's disease |
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