Pyrrolidine dithiocarbamate-induced apoptosis depends on cell type, density, and the presence of Cu 2+ and Zn 2

Pyrrolidine dithiocarbamate (PDTC) has been found to induce or inhibit apoptosis in different cell types. Here we show that PDTC dose-dependently reduced the viability of rat smooth muscle cells (rSMC), human fibroblasts, and endothelial cells at low but not at high cell density. Endothelial cells w...

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Veröffentlicht in:American Journal of Physiology: Cell Physiology 2000-06, Vol.278 (6), p.C1116-C1125
Hauptverfasser: Erl, Wolfgang, Weber, Christian, Hansson, Göran K.
Format: Artikel
Sprache:eng
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