Nestin Expression in Embryonic and Adult Human Teeth under Normal and Pathological Conditions
Nestin is an intermediate filament most related to neurofilaments and expressed predominantly in the developing nervous system and muscles. In the present study we examined the in vivodistribution of nestin in human teeth during embryonic development and in permanent teeth under normal and pathologi...
Gespeichert in:
| Veröffentlicht in: | The American journal of pathology 2000-07, Vol.157 (1), p.287-295 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 295 |
|---|---|
| container_issue | 1 |
| container_start_page | 287 |
| container_title | The American journal of pathology |
| container_volume | 157 |
| creator | About, Imad Laurent-Maquin, Dominique Lendahl, Urban Mitsiadis, Thimios A. |
| description | Nestin is an intermediate filament most related to neurofilaments and expressed predominantly in the developing nervous system and muscles. In the present study we examined the
in vivodistribution of nestin in human teeth during embryonic development and in permanent teeth under normal and pathological conditions. The results show that nestin is first expressed at the bell stage and that its distribution is restricted in pulpal cells located at the cusp area of the fetal teeth. In young permanent teeth, nestin is found only in functional odontoblasts, which produce the hard tissue matrix of dentin. Expression is progressively down-regulated and nestin is absent from older permanent teeth. In carious and injured teeth, nestin expression is up-regulated in a selective manner in odontoblasts surrounding the injury site, showing a link between tissue repair competence and nestin up-regulation under pathological conditions. In an
in vitro assay system of human dental pulp explants, nestin is up-regulated after local application of bone morphogenic protein-4. A similar effect is seen in cultures of primary pulp cells during their differentiation into odontoblasts. Taken together, these results suggest that nestin plays a potential role in odontoblast differentiation during normal and pathological conditions and that bone morphogenic protein-4 is involved in nestin up-regulation. |
| doi_str_mv | 10.1016/S0002-9440(10)64539-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_601389</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002944010645397</els_id><sourcerecordid>56515766</sourcerecordid><originalsourceid>FETCH-LOGICAL-c691t-c3d1f80f03ae573b2fe48837f5372ec91d87ad410e85a93db87b14f468e56a0b3</originalsourceid><addsrcrecordid>eNqFkt2O0zAQhSMEYsvCI4AihBBIBDxxEjs3oKpaKFK1ILFcIstxJq1LYhc76bJvj9NU-3fDle3xN8fjmRNFz4G8BwLFhx-EkDQps4y8AfK2yHJaJuxBNIM8zZMUSngYza6Rk-iJ99twLCgnj6MTIJwTWvJZ9Oscfa9NfPZ359B7bU08nrrKXVmjVSxNHc_roe3j5dBJE18g9pt4MDW6-Ny6TrYH5LvsN7a1a61CYGFNrfsg5Z9GjxrZenx2XE-jn5_PLhbLZPXty9fFfJWoooQ-UbSGhpOGUIk5o1XaYMY5ZU1OWYqqhJozWWdAkOeypHXFWQVZkxUc80KSip5GyaTrL3E3VGLndCfdlbBSi2Pod9ihKAhQXgb-48SHmw5rhaZ3sr2TdvfG6I1Y270AnhMoWRB4Nwls7qUt5yuhjUfXibHdJc_4HgL--vies3-G0HHRaa-wbaVBO3jBIC1IkdIAvrwHbu3gTOidSIGXLECjWj5BylnvHTbXFQARoznEwRxinPwYOphDjEW_uP3rW1mTGwLw6ghIHwbZOGmU9jdcRimh7OY3G73eXGqHwgcftEEVhNzuIGcCRMpH8NMEYpj9XqMTXmk0CuuQpHpRW_2fkv8BhgHjoA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218970621</pqid></control><display><type>article</type><title>Nestin Expression in Embryonic and Adult Human Teeth under Normal and Pathological Conditions</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>SWEPUB Freely available online</source><creator>About, Imad ; Laurent-Maquin, Dominique ; Lendahl, Urban ; Mitsiadis, Thimios A.</creator><creatorcontrib>About, Imad ; Laurent-Maquin, Dominique ; Lendahl, Urban ; Mitsiadis, Thimios A.</creatorcontrib><description>Nestin is an intermediate filament most related to neurofilaments and expressed predominantly in the developing nervous system and muscles. In the present study we examined the
in vivodistribution of nestin in human teeth during embryonic development and in permanent teeth under normal and pathological conditions. The results show that nestin is first expressed at the bell stage and that its distribution is restricted in pulpal cells located at the cusp area of the fetal teeth. In young permanent teeth, nestin is found only in functional odontoblasts, which produce the hard tissue matrix of dentin. Expression is progressively down-regulated and nestin is absent from older permanent teeth. In carious and injured teeth, nestin expression is up-regulated in a selective manner in odontoblasts surrounding the injury site, showing a link between tissue repair competence and nestin up-regulation under pathological conditions. In an
in vitro assay system of human dental pulp explants, nestin is up-regulated after local application of bone morphogenic protein-4. A similar effect is seen in cultures of primary pulp cells during their differentiation into odontoblasts. Taken together, these results suggest that nestin plays a potential role in odontoblast differentiation during normal and pathological conditions and that bone morphogenic protein-4 is involved in nestin up-regulation.</description><identifier>ISSN: 0002-9440</identifier><identifier>EISSN: 1525-2191</identifier><identifier>DOI: 10.1016/S0002-9440(10)64539-7</identifier><identifier>PMID: 10880398</identifier><identifier>CODEN: AJPAA4</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Age Factors ; Animals ; Bioengineering ; Biological and medical sciences ; Bone Morphogenetic Protein 4 ; Bone Morphogenetic Proteins ; Bone Morphogenetic Proteins - pharmacology ; Cells, Cultured ; Dental Caries ; Dental Caries - metabolism ; Dental Caries - pathology ; Dental Pulp ; Dental Pulp - chemistry ; Dental Pulp - cytology ; Dental Pulp - drug effects ; Fetus ; Fundamental and applied biological sciences. Psychology ; Gestational Age ; Humans ; Immunohistochemistry ; Intermediate Filament Proteins ; Intermediate Filament Proteins - biosynthesis ; Intermediate Filament Proteins - drug effects ; Life Sciences ; Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus ; Nerve Tissue Proteins ; Nestin ; Regular ; Research Support, Non-U.S. Gov ; Tooth - chemistry ; Tooth - embryology ; Tooth - pathology ; Tooth Germ - chemistry ; Tooth Germ - embryology ; Vertebrates: digestive system</subject><ispartof>The American journal of pathology, 2000-07, Vol.157 (1), p.287-295</ispartof><rights>2000 American Society for Investigative Pathology</rights><rights>2000 INIST-CNRS</rights><rights>Copyright American Society for Investigative Pathology Jul 2000</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>Copyright © 2000, American Society for Investigative Pathology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c691t-c3d1f80f03ae573b2fe48837f5372ec91d87ad410e85a93db87b14f468e56a0b3</citedby><cites>FETCH-LOGICAL-c691t-c3d1f80f03ae573b2fe48837f5372ec91d87ad410e85a93db87b14f468e56a0b3</cites><orcidid>0000-0002-7453-3921</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1850197/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0002944010645397$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,550,723,776,780,881,3537,27901,27902,53766,53768,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1433037$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10880398$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-00069848$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1961350$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>About, Imad</creatorcontrib><creatorcontrib>Laurent-Maquin, Dominique</creatorcontrib><creatorcontrib>Lendahl, Urban</creatorcontrib><creatorcontrib>Mitsiadis, Thimios A.</creatorcontrib><title>Nestin Expression in Embryonic and Adult Human Teeth under Normal and Pathological Conditions</title><title>The American journal of pathology</title><addtitle>Am J Pathol</addtitle><description>Nestin is an intermediate filament most related to neurofilaments and expressed predominantly in the developing nervous system and muscles. In the present study we examined the
in vivodistribution of nestin in human teeth during embryonic development and in permanent teeth under normal and pathological conditions. The results show that nestin is first expressed at the bell stage and that its distribution is restricted in pulpal cells located at the cusp area of the fetal teeth. In young permanent teeth, nestin is found only in functional odontoblasts, which produce the hard tissue matrix of dentin. Expression is progressively down-regulated and nestin is absent from older permanent teeth. In carious and injured teeth, nestin expression is up-regulated in a selective manner in odontoblasts surrounding the injury site, showing a link between tissue repair competence and nestin up-regulation under pathological conditions. In an
in vitro assay system of human dental pulp explants, nestin is up-regulated after local application of bone morphogenic protein-4. A similar effect is seen in cultures of primary pulp cells during their differentiation into odontoblasts. Taken together, these results suggest that nestin plays a potential role in odontoblast differentiation during normal and pathological conditions and that bone morphogenic protein-4 is involved in nestin up-regulation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Animals</subject><subject>Bioengineering</subject><subject>Biological and medical sciences</subject><subject>Bone Morphogenetic Protein 4</subject><subject>Bone Morphogenetic Proteins</subject><subject>Bone Morphogenetic Proteins - pharmacology</subject><subject>Cells, Cultured</subject><subject>Dental Caries</subject><subject>Dental Caries - metabolism</subject><subject>Dental Caries - pathology</subject><subject>Dental Pulp</subject><subject>Dental Pulp - chemistry</subject><subject>Dental Pulp - cytology</subject><subject>Dental Pulp - drug effects</subject><subject>Fetus</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Intermediate Filament Proteins</subject><subject>Intermediate Filament Proteins - biosynthesis</subject><subject>Intermediate Filament Proteins - drug effects</subject><subject>Life Sciences</subject><subject>Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus</subject><subject>Nerve Tissue Proteins</subject><subject>Nestin</subject><subject>Regular</subject><subject>Research Support, Non-U.S. Gov</subject><subject>Tooth - chemistry</subject><subject>Tooth - embryology</subject><subject>Tooth - pathology</subject><subject>Tooth Germ - chemistry</subject><subject>Tooth Germ - embryology</subject><subject>Vertebrates: digestive system</subject><issn>0002-9440</issn><issn>1525-2191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><recordid>eNqFkt2O0zAQhSMEYsvCI4AihBBIBDxxEjs3oKpaKFK1ILFcIstxJq1LYhc76bJvj9NU-3fDle3xN8fjmRNFz4G8BwLFhx-EkDQps4y8AfK2yHJaJuxBNIM8zZMUSngYza6Rk-iJ99twLCgnj6MTIJwTWvJZ9Oscfa9NfPZ359B7bU08nrrKXVmjVSxNHc_roe3j5dBJE18g9pt4MDW6-Ny6TrYH5LvsN7a1a61CYGFNrfsg5Z9GjxrZenx2XE-jn5_PLhbLZPXty9fFfJWoooQ-UbSGhpOGUIk5o1XaYMY5ZU1OWYqqhJozWWdAkOeypHXFWQVZkxUc80KSip5GyaTrL3E3VGLndCfdlbBSi2Pod9ihKAhQXgb-48SHmw5rhaZ3sr2TdvfG6I1Y270AnhMoWRB4Nwls7qUt5yuhjUfXibHdJc_4HgL--vies3-G0HHRaa-wbaVBO3jBIC1IkdIAvrwHbu3gTOidSIGXLECjWj5BylnvHTbXFQARoznEwRxinPwYOphDjEW_uP3rW1mTGwLw6ghIHwbZOGmU9jdcRimh7OY3G73eXGqHwgcftEEVhNzuIGcCRMpH8NMEYpj9XqMTXmk0CuuQpHpRW_2fkv8BhgHjoA</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>About, Imad</creator><creator>Laurent-Maquin, Dominique</creator><creator>Lendahl, Urban</creator><creator>Mitsiadis, Thimios A.</creator><general>Elsevier Inc</general><general>ASIP</general><general>American Society for Investigative Pathology</general><general>American Society for Investigative Pathology / Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>1XC</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-7453-3921</orcidid></search><sort><creationdate>20000701</creationdate><title>Nestin Expression in Embryonic and Adult Human Teeth under Normal and Pathological Conditions</title><author>About, Imad ; Laurent-Maquin, Dominique ; Lendahl, Urban ; Mitsiadis, Thimios A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c691t-c3d1f80f03ae573b2fe48837f5372ec91d87ad410e85a93db87b14f468e56a0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Animals</topic><topic>Bioengineering</topic><topic>Biological and medical sciences</topic><topic>Bone Morphogenetic Protein 4</topic><topic>Bone Morphogenetic Proteins</topic><topic>Bone Morphogenetic Proteins - pharmacology</topic><topic>Cells, Cultured</topic><topic>Dental Caries</topic><topic>Dental Caries - metabolism</topic><topic>Dental Caries - pathology</topic><topic>Dental Pulp</topic><topic>Dental Pulp - chemistry</topic><topic>Dental Pulp - cytology</topic><topic>Dental Pulp - drug effects</topic><topic>Fetus</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Intermediate Filament Proteins</topic><topic>Intermediate Filament Proteins - biosynthesis</topic><topic>Intermediate Filament Proteins - drug effects</topic><topic>Life Sciences</topic><topic>Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus</topic><topic>Nerve Tissue Proteins</topic><topic>Nestin</topic><topic>Regular</topic><topic>Research Support, Non-U.S. Gov</topic><topic>Tooth - chemistry</topic><topic>Tooth - embryology</topic><topic>Tooth - pathology</topic><topic>Tooth Germ - chemistry</topic><topic>Tooth Germ - embryology</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>About, Imad</creatorcontrib><creatorcontrib>Laurent-Maquin, Dominique</creatorcontrib><creatorcontrib>Lendahl, Urban</creatorcontrib><creatorcontrib>Mitsiadis, Thimios A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Science Journals</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>The American journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>About, Imad</au><au>Laurent-Maquin, Dominique</au><au>Lendahl, Urban</au><au>Mitsiadis, Thimios A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nestin Expression in Embryonic and Adult Human Teeth under Normal and Pathological Conditions</atitle><jtitle>The American journal of pathology</jtitle><addtitle>Am J Pathol</addtitle><date>2000-07-01</date><risdate>2000</risdate><volume>157</volume><issue>1</issue><spage>287</spage><epage>295</epage><pages>287-295</pages><issn>0002-9440</issn><eissn>1525-2191</eissn><coden>AJPAA4</coden><abstract>Nestin is an intermediate filament most related to neurofilaments and expressed predominantly in the developing nervous system and muscles. In the present study we examined the
in vivodistribution of nestin in human teeth during embryonic development and in permanent teeth under normal and pathological conditions. The results show that nestin is first expressed at the bell stage and that its distribution is restricted in pulpal cells located at the cusp area of the fetal teeth. In young permanent teeth, nestin is found only in functional odontoblasts, which produce the hard tissue matrix of dentin. Expression is progressively down-regulated and nestin is absent from older permanent teeth. In carious and injured teeth, nestin expression is up-regulated in a selective manner in odontoblasts surrounding the injury site, showing a link between tissue repair competence and nestin up-regulation under pathological conditions. In an
in vitro assay system of human dental pulp explants, nestin is up-regulated after local application of bone morphogenic protein-4. A similar effect is seen in cultures of primary pulp cells during their differentiation into odontoblasts. Taken together, these results suggest that nestin plays a potential role in odontoblast differentiation during normal and pathological conditions and that bone morphogenic protein-4 is involved in nestin up-regulation.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>10880398</pmid><doi>10.1016/S0002-9440(10)64539-7</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7453-3921</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9440 |
| ispartof | The American journal of pathology, 2000-07, Vol.157 (1), p.287-295 |
| issn | 0002-9440 1525-2191 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_601389 |
| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; SWEPUB Freely available online |
| subjects | Adolescent Adult Age Factors Animals Bioengineering Biological and medical sciences Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins Bone Morphogenetic Proteins - pharmacology Cells, Cultured Dental Caries Dental Caries - metabolism Dental Caries - pathology Dental Pulp Dental Pulp - chemistry Dental Pulp - cytology Dental Pulp - drug effects Fetus Fundamental and applied biological sciences. Psychology Gestational Age Humans Immunohistochemistry Intermediate Filament Proteins Intermediate Filament Proteins - biosynthesis Intermediate Filament Proteins - drug effects Life Sciences Mouth. Exocrine and endocrine salivary glands. Teeth. Esophagus Nerve Tissue Proteins Nestin Regular Research Support, Non-U.S. Gov Tooth - chemistry Tooth - embryology Tooth - pathology Tooth Germ - chemistry Tooth Germ - embryology Vertebrates: digestive system |
| title | Nestin Expression in Embryonic and Adult Human Teeth under Normal and Pathological Conditions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T03%3A44%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Nestin%20Expression%20in%20Embryonic%20and%20Adult%20Human%20Teeth%20under%20Normal%20and%20Pathological%20Conditions&rft.jtitle=The%20American%20journal%20of%20pathology&rft.au=About,%20Imad&rft.date=2000-07-01&rft.volume=157&rft.issue=1&rft.spage=287&rft.epage=295&rft.pages=287-295&rft.issn=0002-9440&rft.eissn=1525-2191&rft.coden=AJPAA4&rft_id=info:doi/10.1016/S0002-9440(10)64539-7&rft_dat=%3Cproquest_swepu%3E56515766%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=218970621&rft_id=info:pmid/10880398&rft_els_id=S0002944010645397&rfr_iscdi=true |