Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice

The multiplicity of Notch receptors raises the question of the contribution of specific isoforms to T‐cell development. Notch3 is expressed in CD4 − 8 − thymocytes and is down‐regulated across the CD4 − 8 − to CD4 + 8 + transition, controlled by pre‐T‐cell receptor signaling. To determine the effect...

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Veröffentlicht in:	The EMBO journal 2000-07, Vol.19 (13), p.3337-3348
Hauptverfasser:	Bellavia, Diana, Campese, Antonio F., Alesse, Edoardo, Vacca, Alessandra, Felli, Maria Pia, Balestri, Anna, Stoppacciaro, Antonella, Tiveron, Cecilia, Tatangelo, Laura, Giovarelli, Mirella, Gaetano, Carlo, Ruco, Luigi, Hoffman, Eric S., Hayday, Adrian C., Lendahl, Urban, Frati, Luigi, Gulino, Alberto, Screpanti, Isabella
Format:	Artikel
Sprache:	eng
Schlagworte:	CD4 antigen CD8 antigen NF-κB Notch3 Notch3 protein pre-TCR T-cell malignancy
Online-Zugang:	Volltext
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