Chlamydia pneumoniae seropositivity is associated with carotid artery intima-media thickness
Infection may both augment the atherosclerotic process and contribute to later manifestations of overt clinical disease. Chlamydia pneumoniae elementary bodies have been detected in atherosclerotic lesions. The aim of the present study was to investigate whether elevated titers of antibodies and cir...
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| Veröffentlicht in: | Stroke (1970) 2000-07, Vol.31 (7), p.1526-1531 |
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| container_title | Stroke (1970) |
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| creator | SCHMIDT, C HULTHE, J WIKSTRAND, J GNARPE, H GNARPE, J AGEWALL, S FAGERBERG, B |
| description | Infection may both augment the atherosclerotic process and contribute to later manifestations of overt clinical disease. Chlamydia pneumoniae elementary bodies have been detected in atherosclerotic lesions. The aim of the present study was to investigate whether elevated titers of antibodies and circulating immune complexes to C pneumoniae were associated with ultrasound findings indicating presence of atherosclerosis in the carotid artery.
Serum titers of antibodies to C pneumoniae (IgM, IgA, IgG, and circulating immune complex) were related to intima-media thickness (IMT) and plaque status measured by B-mode ultrasound in the carotid artery in 113 men with treated hypertension and at least 1 of the following risk factors: hypercholesterolemia, smoking, or diabetes.
Any of the titers was elevated in 56 (50%) men, and common carotid artery IMT was thicker in this group compared with the 57 men without any elevated titers (1.00 versus 0.92 mm, P |
| doi_str_mv | 10.1161/01.STR.31.7.1526 |
| format | Article |
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Serum titers of antibodies to C pneumoniae (IgM, IgA, IgG, and circulating immune complex) were related to intima-media thickness (IMT) and plaque status measured by B-mode ultrasound in the carotid artery in 113 men with treated hypertension and at least 1 of the following risk factors: hypercholesterolemia, smoking, or diabetes.
Any of the titers was elevated in 56 (50%) men, and common carotid artery IMT was thicker in this group compared with the 57 men without any elevated titers (1.00 versus 0.92 mm, P<0.05). There were no accompanying differences in blood pressure, lipid levels, blood glucose, or smoking. Elevation of separate antibody types and circulation immune complex were also associated with increased IMT. In the latter group, systolic blood pressure was higher among seropositive patients compared with those who had no circulating immune complex. Seropositivity was not related to plaque status.
Seropositivity for C pneumoniae was associated with an increased intima-media thickness in the common carotid artery but not plaque status in hypertensive men at high risk for cardiovascular disease.</description><identifier>ISSN: 0039-2499</identifier><identifier>ISSN: 1524-4628</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.STR.31.7.1526</identifier><identifier>PMID: 10884448</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Aged ; Antibodies, Bacterial - blood ; Antigen-Antibody Complex - blood ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; carotid arteries chlamydia ; Carotid Artery Diseases - epidemiology ; Carotid Artery Diseases - microbiology ; Carotid Artery Diseases - pathology ; Carotid Artery, Common - microbiology ; Carotid Artery, Common - pathology ; Chlamydia Infections - epidemiology ; Chlamydia Infections - immunology ; Chlamydia Infections - pathology ; Chlamydophila pneumoniae ; Fysiologi ; Humans ; Immunoglobulin A - blood ; Immunoglobulin G - blood ; Immunoglobulin M - blood ; Male ; Medical sciences ; MEDICIN ; MEDICINE ; Middle Aged ; Physiology ; Random Allocation ; Risk Factors ; Seroepidemiologic Studies ; Tunica Intima - microbiology ; Tunica Intima - pathology</subject><ispartof>Stroke (1970), 2000-07, Vol.31 (7), p.1526-1531</ispartof><rights>2000 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. Jul 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-24ce22943584bd625d16354c7fe1444252174cdf377d3f155271e7fc670bb7b83</citedby><cites>FETCH-LOGICAL-c540t-24ce22943584bd625d16354c7fe1444252174cdf377d3f155271e7fc670bb7b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3685,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1430930$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10884448$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-54539$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/52838$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:16684486$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>SCHMIDT, C</creatorcontrib><creatorcontrib>HULTHE, J</creatorcontrib><creatorcontrib>WIKSTRAND, J</creatorcontrib><creatorcontrib>GNARPE, H</creatorcontrib><creatorcontrib>GNARPE, J</creatorcontrib><creatorcontrib>AGEWALL, S</creatorcontrib><creatorcontrib>FAGERBERG, B</creatorcontrib><title>Chlamydia pneumoniae seropositivity is associated with carotid artery intima-media thickness</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Infection may both augment the atherosclerotic process and contribute to later manifestations of overt clinical disease. Chlamydia pneumoniae elementary bodies have been detected in atherosclerotic lesions. The aim of the present study was to investigate whether elevated titers of antibodies and circulating immune complexes to C pneumoniae were associated with ultrasound findings indicating presence of atherosclerosis in the carotid artery.
Serum titers of antibodies to C pneumoniae (IgM, IgA, IgG, and circulating immune complex) were related to intima-media thickness (IMT) and plaque status measured by B-mode ultrasound in the carotid artery in 113 men with treated hypertension and at least 1 of the following risk factors: hypercholesterolemia, smoking, or diabetes.
Any of the titers was elevated in 56 (50%) men, and common carotid artery IMT was thicker in this group compared with the 57 men without any elevated titers (1.00 versus 0.92 mm, P<0.05). There were no accompanying differences in blood pressure, lipid levels, blood glucose, or smoking. Elevation of separate antibody types and circulation immune complex were also associated with increased IMT. In the latter group, systolic blood pressure was higher among seropositive patients compared with those who had no circulating immune complex. Seropositivity was not related to plaque status.
Seropositivity for C pneumoniae was associated with an increased intima-media thickness in the common carotid artery but not plaque status in hypertensive men at high risk for cardiovascular disease.</description><subject>Aged</subject><subject>Antibodies, Bacterial - blood</subject><subject>Antigen-Antibody Complex - blood</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>carotid arteries chlamydia</subject><subject>Carotid Artery Diseases - epidemiology</subject><subject>Carotid Artery Diseases - microbiology</subject><subject>Carotid Artery Diseases - pathology</subject><subject>Carotid Artery, Common - microbiology</subject><subject>Carotid Artery, Common - pathology</subject><subject>Chlamydia Infections - epidemiology</subject><subject>Chlamydia Infections - immunology</subject><subject>Chlamydia Infections - pathology</subject><subject>Chlamydophila pneumoniae</subject><subject>Fysiologi</subject><subject>Humans</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin M - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MEDICIN</subject><subject>MEDICINE</subject><subject>Middle Aged</subject><subject>Physiology</subject><subject>Random Allocation</subject><subject>Risk Factors</subject><subject>Seroepidemiologic Studies</subject><subject>Tunica Intima - microbiology</subject><subject>Tunica Intima - pathology</subject><issn>0039-2499</issn><issn>1524-4628</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1ktuL1DAUxoMo7rj67pMUEV-0NSeXpn1cxissCLr6JIQ0TWey2zY1F5f5702ZQUXYpxMOv_Pl45wPoaeAK4Aa3mCovl59qShUogJO6ntokwsrWU2a-2iDMW1Lwtr2DD0K4RpjTGjDH6IzwE3DGGs26Md2P6rp0FtVLLNJk5utMkUw3i0u2Gh_2XgobChUCE5bFU1f3Nq4L7TyLtq-UD4an4k52kmVk1mF4t7qm9mE8Bg9GNQYzJNTPUff3r-72n4sLz9_-LS9uCw1Zzhmh9oQ0jLKG9b1NeE91JQzLQYD2SXhBATT_UCF6OkAnBMBRgy6FrjrRNfQc1QedcOtWVInF5_N-IN0yspT6ya_jKwxUN5m_vWd_C4tMrd2aeU5aegq_-pO_K39fiGd38mUJGecruIvj_Ti3c9kQpSTDdqMo5qNS0EKIKxmgmbw-X_gtUt-zouS0ArRtLiFDOEjpL0LwZvhz--A5ZoBiUHmDEgKUsg1A3nk2Uk3dfkg_wwcj56BFydABa3GwatZ2_CXYxS3FNPf4Cm6_w</recordid><startdate>20000701</startdate><enddate>20000701</enddate><creator>SCHMIDT, C</creator><creator>HULTHE, J</creator><creator>WIKSTRAND, J</creator><creator>GNARPE, H</creator><creator>GNARPE, J</creator><creator>AGEWALL, S</creator><creator>FAGERBERG, B</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope><scope>F1U</scope></search><sort><creationdate>20000701</creationdate><title>Chlamydia pneumoniae seropositivity is associated with carotid artery intima-media thickness</title><author>SCHMIDT, C ; HULTHE, J ; WIKSTRAND, J ; GNARPE, H ; GNARPE, J ; AGEWALL, S ; FAGERBERG, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c540t-24ce22943584bd625d16354c7fe1444252174cdf377d3f155271e7fc670bb7b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Antibodies, Bacterial - blood</topic><topic>Antigen-Antibody Complex - blood</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>carotid arteries chlamydia</topic><topic>Carotid Artery Diseases - epidemiology</topic><topic>Carotid Artery Diseases - microbiology</topic><topic>Carotid Artery Diseases - pathology</topic><topic>Carotid Artery, Common - microbiology</topic><topic>Carotid Artery, Common - pathology</topic><topic>Chlamydia Infections - epidemiology</topic><topic>Chlamydia Infections - immunology</topic><topic>Chlamydia Infections - pathology</topic><topic>Chlamydophila pneumoniae</topic><topic>Fysiologi</topic><topic>Humans</topic><topic>Immunoglobulin A - blood</topic><topic>Immunoglobulin G - blood</topic><topic>Immunoglobulin M - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MEDICIN</topic><topic>MEDICINE</topic><topic>Middle Aged</topic><topic>Physiology</topic><topic>Random Allocation</topic><topic>Risk Factors</topic><topic>Seroepidemiologic Studies</topic><topic>Tunica Intima - microbiology</topic><topic>Tunica Intima - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHMIDT, C</creatorcontrib><creatorcontrib>HULTHE, J</creatorcontrib><creatorcontrib>WIKSTRAND, J</creatorcontrib><creatorcontrib>GNARPE, H</creatorcontrib><creatorcontrib>GNARPE, J</creatorcontrib><creatorcontrib>AGEWALL, S</creatorcontrib><creatorcontrib>FAGERBERG, B</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><collection>SWEPUB Göteborgs universitet</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHMIDT, C</au><au>HULTHE, J</au><au>WIKSTRAND, J</au><au>GNARPE, H</au><au>GNARPE, J</au><au>AGEWALL, S</au><au>FAGERBERG, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chlamydia pneumoniae seropositivity is associated with carotid artery intima-media thickness</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2000-07-01</date><risdate>2000</risdate><volume>31</volume><issue>7</issue><spage>1526</spage><epage>1531</epage><pages>1526-1531</pages><issn>0039-2499</issn><issn>1524-4628</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>Infection may both augment the atherosclerotic process and contribute to later manifestations of overt clinical disease. Chlamydia pneumoniae elementary bodies have been detected in atherosclerotic lesions. The aim of the present study was to investigate whether elevated titers of antibodies and circulating immune complexes to C pneumoniae were associated with ultrasound findings indicating presence of atherosclerosis in the carotid artery.
Serum titers of antibodies to C pneumoniae (IgM, IgA, IgG, and circulating immune complex) were related to intima-media thickness (IMT) and plaque status measured by B-mode ultrasound in the carotid artery in 113 men with treated hypertension and at least 1 of the following risk factors: hypercholesterolemia, smoking, or diabetes.
Any of the titers was elevated in 56 (50%) men, and common carotid artery IMT was thicker in this group compared with the 57 men without any elevated titers (1.00 versus 0.92 mm, P<0.05). There were no accompanying differences in blood pressure, lipid levels, blood glucose, or smoking. Elevation of separate antibody types and circulation immune complex were also associated with increased IMT. In the latter group, systolic blood pressure was higher among seropositive patients compared with those who had no circulating immune complex. Seropositivity was not related to plaque status.
Seropositivity for C pneumoniae was associated with an increased intima-media thickness in the common carotid artery but not plaque status in hypertensive men at high risk for cardiovascular disease.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>10884448</pmid><doi>10.1161/01.STR.31.7.1526</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Aged Antibodies, Bacterial - blood Antigen-Antibody Complex - blood Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system carotid arteries chlamydia Carotid Artery Diseases - epidemiology Carotid Artery Diseases - microbiology Carotid Artery Diseases - pathology Carotid Artery, Common - microbiology Carotid Artery, Common - pathology Chlamydia Infections - epidemiology Chlamydia Infections - immunology Chlamydia Infections - pathology Chlamydophila pneumoniae Fysiologi Humans Immunoglobulin A - blood Immunoglobulin G - blood Immunoglobulin M - blood Male Medical sciences MEDICIN MEDICINE Middle Aged Physiology Random Allocation Risk Factors Seroepidemiologic Studies Tunica Intima - microbiology Tunica Intima - pathology |
| title | Chlamydia pneumoniae seropositivity is associated with carotid artery intima-media thickness |
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