Increased airway responsiveness after skin sensitisation to 3-carene, studied in isolated guinea pig lungs
Inhalation of 3-carene has been shown to induce bronchoconstriction in concentrations not far from the threshold limit value. In this study, one group of guinea-pigs were sensitised by dermal exposure to 3-carene according to the modified Cumulative Contact Enhancement Test protocol and another grou...
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| Veröffentlicht in: | Toxicology (Amsterdam) 2000-07, Vol.147 (3), p.209-214 |
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| creator | Låstbom, L Boman, A Camner, P Ryrfeldt, Å |
| description | Inhalation of 3-carene has been shown to induce bronchoconstriction in concentrations not far from the threshold limit value. In this study, one group of guinea-pigs were sensitised by dermal exposure to 3-carene according to the modified Cumulative Contact Enhancement Test protocol and another group of animals was used as controls. Lungs from the skin-sensitised and control guinea-pigs were perfused with diluted autologous blood (13 ml blood/87 ml buffer) and exposed to 3-carene at an air concentration of 3000 mg/m
3. In both groups there was a reduction in compliance and conductance but this reduction was significantly (
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| doi_str_mv | 10.1016/S0300-483X(00)00195-5 |
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3. In both groups there was a reduction in compliance and conductance but this reduction was significantly (
P<0.05) more pronounced (2.5–3 times) in lungs obtained from sensitised animals than from control animals. In a previous study with similar design, but with plain buffer instead of diluted autologous blood as perfusate, we found no statistically significant difference in lung bronchoconstriction. Thus, it is concluded that skin sensitisation can increase lung reactivity to 3-carene and that important mediators of this effect seem to be present in the blood.</description><identifier>ISSN: 0300-483X</identifier><identifier>EISSN: 1879-3185</identifier><identifier>DOI: 10.1016/S0300-483X(00)00195-5</identifier><identifier>PMID: 10924802</identifier><identifier>CODEN: TXICDD</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>3-Carene ; Administration, Inhalation ; Administration, Topical ; Allergens - immunology ; Animals ; Biological and medical sciences ; Bronchial Hyperreactivity - blood ; Bronchial Hyperreactivity - chemically induced ; Bronchial Hyperreactivity - immunology ; Bronchial Provocation Tests ; Bronchoconstriction ; Dermal sensitisation ; Drug Hypersensitivity - blood ; Drug Hypersensitivity - immunology ; Female ; Guinea pig ; Guinea Pigs ; Immunization ; Lung ; Lung - drug effects ; Lung - immunology ; Lung Compliance - drug effects ; Lung Compliance - immunology ; Medical sciences ; Monoterpenes ; Perfusion ; Plant poisons toxicology ; Skin - immunology ; Terpenes - immunology ; Toxicology</subject><ispartof>Toxicology (Amsterdam), 2000-07, Vol.147 (3), p.209-214</ispartof><rights>2000 Elsevier Science Ireland Ltd</rights><rights>2000 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-f3045e39e3d72852495be5b61ebc142341d4bfddcfb832b972b7fe0eed073e6a3</citedby><cites>FETCH-LOGICAL-c490t-f3045e39e3d72852495be5b61ebc142341d4bfddcfb832b972b7fe0eed073e6a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0300483X00001955$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1536497$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10924802$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1954929$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Låstbom, L</creatorcontrib><creatorcontrib>Boman, A</creatorcontrib><creatorcontrib>Camner, P</creatorcontrib><creatorcontrib>Ryrfeldt, Å</creatorcontrib><title>Increased airway responsiveness after skin sensitisation to 3-carene, studied in isolated guinea pig lungs</title><title>Toxicology (Amsterdam)</title><addtitle>Toxicology</addtitle><description>Inhalation of 3-carene has been shown to induce bronchoconstriction in concentrations not far from the threshold limit value. In this study, one group of guinea-pigs were sensitised by dermal exposure to 3-carene according to the modified Cumulative Contact Enhancement Test protocol and another group of animals was used as controls. Lungs from the skin-sensitised and control guinea-pigs were perfused with diluted autologous blood (13 ml blood/87 ml buffer) and exposed to 3-carene at an air concentration of 3000 mg/m
3. In both groups there was a reduction in compliance and conductance but this reduction was significantly (
P<0.05) more pronounced (2.5–3 times) in lungs obtained from sensitised animals than from control animals. In a previous study with similar design, but with plain buffer instead of diluted autologous blood as perfusate, we found no statistically significant difference in lung bronchoconstriction. Thus, it is concluded that skin sensitisation can increase lung reactivity to 3-carene and that important mediators of this effect seem to be present in the blood.</description><subject>3-Carene</subject><subject>Administration, Inhalation</subject><subject>Administration, Topical</subject><subject>Allergens - immunology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bronchial Hyperreactivity - blood</subject><subject>Bronchial Hyperreactivity - chemically induced</subject><subject>Bronchial Hyperreactivity - immunology</subject><subject>Bronchial Provocation Tests</subject><subject>Bronchoconstriction</subject><subject>Dermal sensitisation</subject><subject>Drug Hypersensitivity - blood</subject><subject>Drug Hypersensitivity - immunology</subject><subject>Female</subject><subject>Guinea pig</subject><subject>Guinea Pigs</subject><subject>Immunization</subject><subject>Lung</subject><subject>Lung - drug effects</subject><subject>Lung - immunology</subject><subject>Lung Compliance - drug effects</subject><subject>Lung Compliance - immunology</subject><subject>Medical sciences</subject><subject>Monoterpenes</subject><subject>Perfusion</subject><subject>Plant poisons toxicology</subject><subject>Skin - immunology</subject><subject>Terpenes - immunology</subject><subject>Toxicology</subject><issn>0300-483X</issn><issn>1879-3185</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9rFTEQxYMo9rb6EZQ8iCi4Otkk--epSKlaKPiggm8hm8xe0u7NXjO7Lf32ZruX6lufZhh-c3Iyh7FXAj4KENWnHyABCtXI3-8A3gOIVhf6CduIpm4LKRr9lG0ekCN2THQFAKVU1XN2JKAtVQPlhl1dRJfQEnpuQ7q1dzwh7cdI4QYjEnHbT5g4XYfICfN4CmSnMEY-jVwWzqaMfeA0zT5kjUwFGgc75X47h4iW78OWD3Pc0gv2rLcD4ctDPWG_vpz_PPtWXH7_enH2-bJwqoWp6CUojbJF6euy0aVqdYe6qwR2Tqj8AeFV13vv-q6RZdfWZVf3CIgeaomVlSesWHXpFvdzZ_Yp7Gy6M6MN5jC6zh2aCpY7ZP7tyu_T-GdGmswukMNhsBHHmYyoddUoWT8OKq3qql4U9Qq6NBIl7B88CDBLeuY-PbNEY3K9T8_ovPf68MDc7dD_t7XGlYE3B8CSs0OfbHSB_nFaVqpdjJ6uGOYz3wRMhlzA6NCHhG4yfgyPOPkLrfi4tQ</recordid><startdate>20000705</startdate><enddate>20000705</enddate><creator>Låstbom, L</creator><creator>Boman, A</creator><creator>Camner, P</creator><creator>Ryrfeldt, Å</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7U7</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20000705</creationdate><title>Increased airway responsiveness after skin sensitisation to 3-carene, studied in isolated guinea pig lungs</title><author>Låstbom, L ; Boman, A ; Camner, P ; Ryrfeldt, Å</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-f3045e39e3d72852495be5b61ebc142341d4bfddcfb832b972b7fe0eed073e6a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>3-Carene</topic><topic>Administration, Inhalation</topic><topic>Administration, Topical</topic><topic>Allergens - immunology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bronchial Hyperreactivity - blood</topic><topic>Bronchial Hyperreactivity - chemically induced</topic><topic>Bronchial Hyperreactivity - immunology</topic><topic>Bronchial Provocation Tests</topic><topic>Bronchoconstriction</topic><topic>Dermal sensitisation</topic><topic>Drug Hypersensitivity - blood</topic><topic>Drug Hypersensitivity - immunology</topic><topic>Female</topic><topic>Guinea pig</topic><topic>Guinea Pigs</topic><topic>Immunization</topic><topic>Lung</topic><topic>Lung - drug effects</topic><topic>Lung - immunology</topic><topic>Lung Compliance - drug effects</topic><topic>Lung Compliance - immunology</topic><topic>Medical sciences</topic><topic>Monoterpenes</topic><topic>Perfusion</topic><topic>Plant poisons toxicology</topic><topic>Skin - immunology</topic><topic>Terpenes - immunology</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Låstbom, L</creatorcontrib><creatorcontrib>Boman, A</creatorcontrib><creatorcontrib>Camner, P</creatorcontrib><creatorcontrib>Ryrfeldt, Å</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Toxicology (Amsterdam)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Låstbom, L</au><au>Boman, A</au><au>Camner, P</au><au>Ryrfeldt, Å</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased airway responsiveness after skin sensitisation to 3-carene, studied in isolated guinea pig lungs</atitle><jtitle>Toxicology (Amsterdam)</jtitle><addtitle>Toxicology</addtitle><date>2000-07-05</date><risdate>2000</risdate><volume>147</volume><issue>3</issue><spage>209</spage><epage>214</epage><pages>209-214</pages><issn>0300-483X</issn><eissn>1879-3185</eissn><coden>TXICDD</coden><abstract>Inhalation of 3-carene has been shown to induce bronchoconstriction in concentrations not far from the threshold limit value. In this study, one group of guinea-pigs were sensitised by dermal exposure to 3-carene according to the modified Cumulative Contact Enhancement Test protocol and another group of animals was used as controls. Lungs from the skin-sensitised and control guinea-pigs were perfused with diluted autologous blood (13 ml blood/87 ml buffer) and exposed to 3-carene at an air concentration of 3000 mg/m
3. In both groups there was a reduction in compliance and conductance but this reduction was significantly (
P<0.05) more pronounced (2.5–3 times) in lungs obtained from sensitised animals than from control animals. In a previous study with similar design, but with plain buffer instead of diluted autologous blood as perfusate, we found no statistically significant difference in lung bronchoconstriction. Thus, it is concluded that skin sensitisation can increase lung reactivity to 3-carene and that important mediators of this effect seem to be present in the blood.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>10924802</pmid><doi>10.1016/S0300-483X(00)00195-5</doi><tpages>6</tpages></addata></record> |
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| subjects | 3-Carene Administration, Inhalation Administration, Topical Allergens - immunology Animals Biological and medical sciences Bronchial Hyperreactivity - blood Bronchial Hyperreactivity - chemically induced Bronchial Hyperreactivity - immunology Bronchial Provocation Tests Bronchoconstriction Dermal sensitisation Drug Hypersensitivity - blood Drug Hypersensitivity - immunology Female Guinea pig Guinea Pigs Immunization Lung Lung - drug effects Lung - immunology Lung Compliance - drug effects Lung Compliance - immunology Medical sciences Monoterpenes Perfusion Plant poisons toxicology Skin - immunology Terpenes - immunology Toxicology |
| title | Increased airway responsiveness after skin sensitisation to 3-carene, studied in isolated guinea pig lungs |
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