Functional uncoupling of adenosine A(2A) receptors and reduced responseto caffeine in mice lacking dopamine D2 receptors

Dopamine D(2) receptors (Rs) and adenosine A(2A)Rs are coexpressed on striatopallidal neurons, where they mediate opposing actions. In agreement with the idea that D(2)Rs tonically inhibit GABA release from these neurons, stimulation-evoked GABA release was significantly greater from striatal/pallid...

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Veröffentlicht in:	The Journal of neuroscience 2000-08, Vol.20 (16), p.5949-5957
Hauptverfasser:	Zahniser, N R, Simosky, J K, Mayfield, R D, Negri, C A, Hanania, T, Larson, G A, Kelly, M A, Grandy, D K, Rubinstein, M, Low, M J, Fredholm, B B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basal Ganglia Diseases - drug therapy Basal Ganglia Diseases - physiopathology Caffeine - pharmacology Cyclic AMP - metabolism Female gamma-Aminobutyric Acid - metabolism Globus Pallidus - cytology Globus Pallidus - drug effects Globus Pallidus - metabolism In Vitro Techniques Male Medicin och hälsovetenskap Mice Mice, Congenic Mice, Knockout Motor Activity - drug effects Motor Activity - physiology Neostriatum - cytology Neostriatum - drug effects Neostriatum - metabolism Neural Pathways - cytology Neural Pathways - drug effects Neural Pathways - metabolism Proto-Oncogene Proteins c-fos - drug effects Proto-Oncogene Proteins c-fos - metabolism Receptor, Adenosine A2A Receptors, Dopamine D2 - drug effects Receptors, Dopamine D2 - genetics Receptors, Dopamine D2 - metabolism Receptors, Purinergic P1 - drug effects Receptors, Purinergic P1 - genetics Receptors, Purinergic P1 - metabolism RNA, Messenger - drug effects RNA, Messenger - metabolism
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