Fission and uncoating of synaptic clathrin-coated vesicles are perturbed by disruption of interactions with the SH3 domain of endophilin

Coordination between sequential steps in synaptic vesicle endocytosis, including clathrin coat formation, fission, and uncoating, appears to involve proteinprotein interactions. Here, we show that compounds that disrupt interactions of the SH3 domain of endophilin with dynamin and synaptojanin impai...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2000-08, Vol.27 (2), p.301-312
Hauptverfasser:	Gad, H, Ringstad, N, Löw, P, Kjaerulff, O, Gustafsson, J, Wenk, M, Di Paolo, G, Nemoto, Y, Crun, J, Ellisman, M H, De Camilli, P, Shupliakov, O, Brodin, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Animals Binding, Competitive - drug effects Carrier Proteins - metabolism Clathrin - metabolism Cloning, Molecular Coated Pits, Cell-Membrane - metabolism Dynamins endophilin GTP Phosphohydrolases - metabolism Lampreys Medicin och hälsovetenskap Microinjections Molecular Sequence Data Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Peptide Fragments - administration & dosage Phosphoric Monoester Hydrolases - genetics Phosphoric Monoester Hydrolases - metabolism Sequence Homology, Amino Acid src Homology Domains - drug effects src Homology Domains - genetics src Homology Domains - physiology Synaptic Vesicles - metabolism synaptojanin
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