Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain

The retinoid X receptor (RXR) is a nuclear receptor that functions as a ligand-activated transcription factor. Little is known about the ligands that activate RXR in vivo. Here, we identified a factor in brain tissue from adult mice that activates RXR in cell-based assays. Purification and analysis...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2000-12, Vol.290 (5499), p.2140-2144
Hauptverfasser:	de Urquiza, Alexander Mata, Liu, Suya, Sjöberg, Maria, Zetterström, Rolf H., Griffiths, William, Sjövall, Jan, Perlmann, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biological and medical sciences Biological Assay Biotechnology industries Biotechnology industry Brain Brain - growth & development Brain - metabolism Brain Chemistry Cell Line Cell physiology Cells Chromatography, High Pressure Liquid Culture Media, Conditioned Dimerization docosahexaenoic acid Docosahexaenoic Acids - isolation & purification Docosahexaenoic Acids - metabolism Docosahexaenoic Acids - pharmacology Fatty acids Fatty Acids, Unsaturated - pharmacology Fractions Fundamental and applied biological sciences. Psychology Genes Goods and services tax Hexanes Histone Acetyltransferases Humans Ligands Ligands (Biochemistry) Male Mass spectroscopy Mice Molecular and cellular biology Monounsaturated fatty acids Neural receptors Nuclear Receptor Coactivator 1 Nuclear receptors Omega 3 fatty acids Receptors Receptors, Retinoic Acid - genetics Receptors, Retinoic Acid - metabolism Recombinant Fusion Proteins - metabolism Retinoid X Receptors Retinoids Rodents Signal Transduction Spectrometry, Mass, Electrospray Ionization Tissues Transcription Factors - genetics Transcription Factors - metabolism Transfection Tumor Cells, Cultured Unsaturated fatty acids
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