Excess Tryptophan Hydroxylase 17 779C Allele in Surviving Cotwins of Monozygotic Twin Suicide Victims
Objective: To evaluate the relationship of the tryptophan hydroxylase (TPH) genotype to suicidality by the study of surviving monozygotic (MZ) cotwins of twins who committed suicide. Method: Twenty-four surviving Swedish MZ twins whose MZ cotwins had committed suicide were compared to 158 demographi...
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| Veröffentlicht in: | Neuropsychobiology 2001-01, Vol.43 (4), p.233-236 |
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| creator | Roy, Alec Rylander, Gunnar Forslund, Kaj Asberg, Marie Mazzanti, Chiara M. Goldman, David Nielsen, David A. |
| description | Objective: To evaluate the relationship of the tryptophan hydroxylase (TPH) genotype to suicidality by the study of surviving monozygotic (MZ) cotwins of twins who committed suicide. Method: Twenty-four surviving Swedish MZ twins whose MZ cotwins had committed suicide were compared to 158 demographically sampled Swedish general population controls for TPH alleles. We also examined serotonin transporter alleles. Results: The living MZ cotwins of suicide victims had a significantly higher TPH 17 779C allele frequency than controls. No significant difference was observed for serotonin transporter alleles. Conclusion: These results, in a small sample, suggest the possibility that the 17 779C allele of the TPH gene may be associated with an increased risk of suicide. Further studies in larger samples are needed. |
| doi_str_mv | 10.1159/000054895 |
| format | Article |
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Method: Twenty-four surviving Swedish MZ twins whose MZ cotwins had committed suicide were compared to 158 demographically sampled Swedish general population controls for TPH alleles. We also examined serotonin transporter alleles. Results: The living MZ cotwins of suicide victims had a significantly higher TPH 17 779C allele frequency than controls. No significant difference was observed for serotonin transporter alleles. Conclusion: These results, in a small sample, suggest the possibility that the 17 779C allele of the TPH gene may be associated with an increased risk of suicide. Further studies in larger samples are needed.</description><identifier>ISSN: 0302-282X</identifier><identifier>EISSN: 1423-0224</identifier><identifier>DOI: 10.1159/000054895</identifier><identifier>PMID: 11340361</identifier><identifier>CODEN: NPBYAL</identifier><language>eng</language><publisher>Basel, Switzerland: Karger</publisher><subject>Adult and adolescent clinical studies ; Alleles ; Biological and medical sciences ; Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels) / Original Paper ; Genotype ; Humans ; Isoenzymes - genetics ; Medical sciences ; Medicin och hälsovetenskap ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Suicide ; Suicide - psychology ; Sweden ; Tryptophan Hydroxylase - genetics ; Twins, Monozygotic - genetics</subject><ispartof>Neuropsychobiology, 2001-01, Vol.43 (4), p.233-236</ispartof><rights>2001 S. Karger AG, Basel</rights><rights>2001 INIST-CNRS</rights><rights>Copyright 2001 S. Karger AG, Basel</rights><rights>Copyright S. Karger AG 2001</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c501t-e80613c2b7d5ddee1a2d2a46407ce13246e5e5b693476f1da71446afc5ae56643</citedby><cites>FETCH-LOGICAL-c501t-e80613c2b7d5ddee1a2d2a46407ce13246e5e5b693476f1da71446afc5ae56643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,2429,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1076840$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11340361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1928073$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Roy, Alec</creatorcontrib><creatorcontrib>Rylander, Gunnar</creatorcontrib><creatorcontrib>Forslund, Kaj</creatorcontrib><creatorcontrib>Asberg, Marie</creatorcontrib><creatorcontrib>Mazzanti, Chiara M.</creatorcontrib><creatorcontrib>Goldman, David</creatorcontrib><creatorcontrib>Nielsen, David A.</creatorcontrib><title>Excess Tryptophan Hydroxylase 17 779C Allele in Surviving Cotwins of Monozygotic Twin Suicide Victims</title><title>Neuropsychobiology</title><addtitle>Neuropsychobiology</addtitle><description>Objective: To evaluate the relationship of the tryptophan hydroxylase (TPH) genotype to suicidality by the study of surviving monozygotic (MZ) cotwins of twins who committed suicide. Method: Twenty-four surviving Swedish MZ twins whose MZ cotwins had committed suicide were compared to 158 demographically sampled Swedish general population controls for TPH alleles. We also examined serotonin transporter alleles. Results: The living MZ cotwins of suicide victims had a significantly higher TPH 17 779C allele frequency than controls. No significant difference was observed for serotonin transporter alleles. Conclusion: These results, in a small sample, suggest the possibility that the 17 779C allele of the TPH gene may be associated with an increased risk of suicide. Further studies in larger samples are needed.</description><subject>Adult and adolescent clinical studies</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels) / Original Paper</subject><subject>Genotype</subject><subject>Humans</subject><subject>Isoenzymes - genetics</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. 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Main Editor: J. Mendlewicz (Brussels) / Original Paper</topic><topic>Genotype</topic><topic>Humans</topic><topic>Isoenzymes - genetics</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. 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Method: Twenty-four surviving Swedish MZ twins whose MZ cotwins had committed suicide were compared to 158 demographically sampled Swedish general population controls for TPH alleles. We also examined serotonin transporter alleles. Results: The living MZ cotwins of suicide victims had a significantly higher TPH 17 779C allele frequency than controls. No significant difference was observed for serotonin transporter alleles. Conclusion: These results, in a small sample, suggest the possibility that the 17 779C allele of the TPH gene may be associated with an increased risk of suicide. Further studies in larger samples are needed.</abstract><cop>Basel, Switzerland</cop><pub>Karger</pub><pmid>11340361</pmid><doi>10.1159/000054895</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuropsychobiology, 2001-01, Vol.43 (4), p.233-236 |
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| language | eng |
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| source | MEDLINE; Karger Journals Complete |
| subjects | Adult and adolescent clinical studies Alleles Biological and medical sciences Biological Psychiatry. Main Editor: J. Mendlewicz (Brussels) / Original Paper Genotype Humans Isoenzymes - genetics Medical sciences Medicin och hälsovetenskap Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Suicide Suicide - psychology Sweden Tryptophan Hydroxylase - genetics Twins, Monozygotic - genetics |
| title | Excess Tryptophan Hydroxylase 17 779C Allele in Surviving Cotwins of Monozygotic Twin Suicide Victims |
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