The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development

Nodal proteins have crucial roles in mesendoderm formation and left-right patterning during vertebrate development. The molecular mechanisms of signal transduction by Nodal and related ligands, however, are not fully understood. In this paper, we present biochemical and functional evidence that the...

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Veröffentlicht in:	Genes & development 2001-08, Vol.15 (15), p.2010-2022
Hauptverfasser:	Reissmann, E, Jörnvall, H, Blokzijl, A, Andersson, O, Chang, C, Minchiotti, G, Persico, M G, Ibáñez, C F, Brivanlou, A H
Format:	Artikel
Sprache:	eng
Schlagworte:	activin Activin Receptors Activin Receptors, Type I ActRIIB protein ALK4 protein ALK7 protein Amino Acid Sequence Animals Congenital Abnormalities - embryology Congenital Abnormalities - genetics Cripto protein Ectoderm - physiology Embryo, Nonmammalian - physiology Epidermal Growth Factor Freshwater Gastrula - physiology Gene Expression Regulation, Developmental GPI-Linked Proteins Homeodomain Proteins Intercellular Signaling Peptides and Proteins Ligands Membrane Glycoproteins Membrane Proteins Mice Molecular Sequence Data Morphogenesis Neoplasm Proteins - metabolism Nodal Protein Nodal-related 1 protein Phylogeny Protein Serine-Threonine Kinases - chemistry Protein Serine-Threonine Kinases - genetics Protein Serine-Threonine Kinases - metabolism Receptors, Growth Factor - chemistry Receptors, Growth Factor - genetics Receptors, Growth Factor - metabolism Research Paper RNA, Messenger - genetics Sequence Alignment Sequence Homology, Amino Acid Signal Transduction Transcription Factors Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - physiology Vertebrates - embryology Xenopus Xenopus laevis - embryology Xenopus Proteins Xnr1 protein Xnr2 protein Xnr4 protein
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