Nicotine-induced alterations in the expression of nicotinic receptors in primary cultures from human prenatal brain

The nicotinic receptor proteins and gene transcripts for the different nicotinic receptor subunits exist in human prenatal brain already at 4–5 weeks of gestation. The early presence of nicotinic receptors suggests an important role for these receptors in modulating dendritic outgrowth, establishmen...

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Veröffentlicht in:	Neuroscience 2001-01, Vol.105 (3), p.527-534
Hauptverfasser:	Hellström-Lindahl, E, Seiger, Å, Kjældgaard, A, Nordberg, A
Format:	Artikel
Sprache:	eng
Schlagworte:	[ 3H]cytisine [ 3H]epibatidine Alkaloids - pharmacokinetics Azocines Binding Sites - drug effects Binding Sites - physiology Binding, Competitive - drug effects Binding, Competitive - physiology Biological and medical sciences Brain - drug effects Brain - embryology Brain - metabolism Bridged Bicyclo Compounds, Heterocyclic - pharmacokinetics Cells, Cultured - drug effects Cells, Cultured - metabolism development Dose-Response Relationship, Drug Drug Interactions - physiology Embryology: invertebrates and vertebrates. Teratology Female fetal Fetus Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - physiology Humans Medicin och hälsovetenskap Molecular embryology mRNA Neurons - drug effects Neurons - metabolism Nicotine - adverse effects Nicotinic Agonists - pharmacokinetics Pregnancy Prenatal Exposure Delayed Effects Pyridines - pharmacokinetics Quinolizines Radioligand Assay Receptors, Nicotinic - drug effects Receptors, Nicotinic - genetics Receptors, Nicotinic - metabolism RNA, Messenger - drug effects RNA, Messenger - metabolism Smoking - adverse effects Tritium - pharmacokinetics up-regulation Up-Regulation - drug effects Up-Regulation - physiology
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