Group I mGluR antagonist AIDA protects nigral DA cells from MPTP-induced injury

The effects of i.c.v. injection of AIDA, a group I mGluR antagonist, were studied on the nigral DA cells after MPTP-induced injury in the black mouse, using TH immunocytochemistry and unbiased stereology. MPTP reduced the total number of TH-IR neurons by 55.2% and non-TH-IR neurons by 27.5%. A 15 mi...

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Veröffentlicht in:	Neuroreport 2001-08, Vol.12 (12), p.2615-2617
Hauptverfasser:	Aguirre, José A, Andbjer, Beth, González-Barón, Salvador, Hansson, Anita, Strömberg, Ingrid, Agnati, Luigi F, Fuxe, Kjell
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine - administration & dosage Animals Biological and medical sciences Cell Count Cell Size - drug effects Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Coloring Agents Dopamine - metabolism Excitatory Amino Acid Antagonists - administration & dosage Fundamental and applied biological sciences. Psychology Immunohistochemistry Indans - administration & dosage Injections, Intraventricular Male Medicin och hälsovetenskap Mice Mice, Inbred C57BL MPTP Poisoning - pathology MPTP Poisoning - prevention & control Neurons - drug effects Neurons - pathology Neuroprotective Agents - administration & dosage Receptors, Metabotropic Glutamate - antagonists & inhibitors Substantia Nigra - drug effects Substantia Nigra - pathology Tyrosine 3-Monooxygenase - analysis Tyrosine 3-Monooxygenase - biosynthesis Vertebrates: nervous system and sense organs
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