Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria

In L929sAhFas cells, tumor necrosis factor (TNF) leads to necrotic cell death, whereas agonistic anti-Fas antibodies elicit apoptotic cell death. Apoptosis, but not necrosis, is correlated with a rapid externalization of phosphatidylserine and the appearance of a hypoploid population. During necrosi...

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Veröffentlicht in:	Cell death and differentiation 2001-08, Vol.8 (8), p.829-840
Hauptverfasser:	Denecker, G, Vercammen, D, Steemans, M, Vanden Berghe, T, Brouckaert, G, Van Loo, G, Zhivotovsky, B, Fiers, W, Grooten, J, Declercq, W, Vandenabeele, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Apoptosis - physiology BH3 Interacting Domain Death Agonist Protein Carrier Proteins - drug effects Carrier Proteins - metabolism Caspases - drug effects Caspases - metabolism Cell death Cytochrome c Group - metabolism fas Receptor - drug effects fas Receptor - metabolism Humans Kinetics Mice Mitochondria - drug effects Mitochondria - metabolism Necrosis Proto-Oncogene Proteins c-bcl-2 - metabolism Reactive Oxygen Species - metabolism Receptors, Tumor Necrosis Factor - drug effects Receptors, Tumor Necrosis Factor - metabolism Serine Endopeptidases - metabolism Serine Proteinase Inhibitors - pharmacology Signal Transduction - physiology Time Factors Tumor Cells, Cultured - cytology Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism Tumor Necrosis Factor-alpha - pharmacology
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