Human immune response to Puumala virus glycoproteins and nucleocapsid protein expressed in mammalian cells

Puumala hantavirus (PUUV) glycoproteins G1 and G2 and nucleocapsid protein (N) were expressed in BHK‐21 cells by transfection of a plasmid producing a recombinant alphavirus replicon. Coexpression of G1 and G2 from separate constructs seemed to be important for the optimal folding of the glycoprotei...

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Veröffentlicht in:	Journal of medical virology 2001-11, Vol.65 (3), p.605-613
Hauptverfasser:	Kallio-Kokko, Hannimari, Leveelahti, Raija, Brummer-Korvenkontio, Markus, Lundkvist, Åke, Vaheri, Antti, Vapalahti, Olli
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Animals Antibodies, Viral - blood antibody kinetics Antigens, Viral - immunology Biological and medical sciences Cell Line Child Cloning, Molecular Female Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology glycoprotein G1 glycoprotein G2 glycoproteins Hantavirus Hemorrhagic Fever with Renal Syndrome - immunology Hemorrhagic Fever with Renal Syndrome - virology Humans IgG-IFA Male mammalian cells Microbiology Middle Aged Nucleocapsid - genetics Nucleocapsid - immunology Nucleocapsid Proteins Puumala virus Puumala virus - immunology recombinant proteins Recombinant Proteins - immunology Transfection Viral Envelope Proteins - genetics Viral Envelope Proteins - immunology
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