A Carbohydrate-Rich Drink Reduces Preoperative Discomfort in Elective Surgery Patients
We studied the effects of different preoperative oral fluid protocols on preoperative discomfort, residual gastric fluid volumes, and gastric acidity. Two-hundred-fifty-two elective abdominal surgery patients (ASA physical status I–II) were randomized to preparation with a 12.5% carbohydrate drink (...
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| Veröffentlicht in: | Anesthesia and analgesia 2001-11, Vol.93 (5), p.1344-1350 |
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| container_title | Anesthesia and analgesia |
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| creator | Hausel, Jonatan Nygren, Jonas Lagerkranser, Michael Hellström, Per M. Hammarqvist, Folke Almström, Caisa Lindh, Annika Thorell, Anders Ljungqvist, Olle |
| description | We studied the effects of different preoperative oral fluid protocols on preoperative discomfort, residual gastric fluid volumes, and gastric acidity. Two-hundred-fifty-two elective abdominal surgery patients (ASA physical status I–II) were randomized to preparation with a 12.5% carbohydrate drink (CHO), placebo (flavored water), or overnight fasting. The CHO and Placebo groups were double-blinded and were given 800 mL to drink on the evening before and 400 mL on the morning of surgery. Visual analog scales were used to score 11 different discomfort variables. CHO did not increase gastric fluid volumes or affect acidity, and there were no adverse events. The visual analog scale scores in a control situation were not different between groups. During the waiting period before surgery, the CHO-treated group was less hungry and less anxious than both the other groups (P ≤ 0.05). CHO reduced thirst as effectively as placebo (P < 0.0001 versus Fasted). Trend analysis showed consistently decreasing thirst, hunger, anxiety, malaise, and unfitness in the CHO group (P < 0.05). The Placebo group experienced decreasing unfitness and malaise, whereas nausea, tiredness, and inability to concentrate increased (P < 0.05). In the Fasted group, hunger, thirst, tiredness, weakness, and inability to concentrate increased (P < 0.05). In conclusion, CHO significantly reduces preoperative discomfort without adversely affecting gastric contents. |
| doi_str_mv | 10.1097/00000539-200111000-00063 |
| format | Article |
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Two-hundred-fifty-two elective abdominal surgery patients (ASA physical status I–II) were randomized to preparation with a 12.5% carbohydrate drink (CHO), placebo (flavored water), or overnight fasting. The CHO and Placebo groups were double-blinded and were given 800 mL to drink on the evening before and 400 mL on the morning of surgery. Visual analog scales were used to score 11 different discomfort variables. CHO did not increase gastric fluid volumes or affect acidity, and there were no adverse events. The visual analog scale scores in a control situation were not different between groups. During the waiting period before surgery, the CHO-treated group was less hungry and less anxious than both the other groups (P ≤ 0.05). CHO reduced thirst as effectively as placebo (P < 0.0001 versus Fasted). Trend analysis showed consistently decreasing thirst, hunger, anxiety, malaise, and unfitness in the CHO group (P < 0.05). The Placebo group experienced decreasing unfitness and malaise, whereas nausea, tiredness, and inability to concentrate increased (P < 0.05). In the Fasted group, hunger, thirst, tiredness, weakness, and inability to concentrate increased (P < 0.05). In conclusion, CHO significantly reduces preoperative discomfort without adversely affecting gastric contents.</description><identifier>ISSN: 0003-2999</identifier><identifier>ISSN: 1526-7598</identifier><identifier>EISSN: 1526-7598</identifier><identifier>DOI: 10.1097/00000539-200111000-00063</identifier><identifier>PMID: 11682427</identifier><identifier>CODEN: AACRAT</identifier><language>eng</language><publisher>Hagerstown, MD: International Anesthesia Research Society</publisher><subject>Adult ; Aged ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Biological and medical sciences ; Cholecystectomy, Laparoscopic ; Dietary Carbohydrates - administration & dosage ; Double-Blind Method ; Elective Surgical Procedures ; Fasting ; Female ; Gastric Acid - metabolism ; Gastric Mucosa - metabolism ; General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation ; Humans ; Hydrogen-Ion Concentration ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Middle Aged ; Pain Measurement - drug effects ; Placebos ; Preoperative Care - methods</subject><ispartof>Anesthesia and analgesia, 2001-11, Vol.93 (5), p.1344-1350</ispartof><rights>International Anesthesia Research Society</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6253-3f0e3366bf5186c0dacb89db6ff3367591319ba0f847bd25992856f4369ab3153</citedby><cites>FETCH-LOGICAL-c6253-3f0e3366bf5186c0dacb89db6ff3367591319ba0f847bd25992856f4369ab3153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf><![CDATA[$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&PDF=y&D=ovft&AN=00000539-200111000-00063$$EPDF$$P50$$Gwolterskluwer$$H]]></linktopdf><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00000539-200111000-00063$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>230,315,782,786,887,4611,27931,27932,64673,65468</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14071247$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11682427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-64076$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1958662$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Hausel, Jonatan</creatorcontrib><creatorcontrib>Nygren, Jonas</creatorcontrib><creatorcontrib>Lagerkranser, Michael</creatorcontrib><creatorcontrib>Hellström, Per M.</creatorcontrib><creatorcontrib>Hammarqvist, Folke</creatorcontrib><creatorcontrib>Almström, Caisa</creatorcontrib><creatorcontrib>Lindh, Annika</creatorcontrib><creatorcontrib>Thorell, Anders</creatorcontrib><creatorcontrib>Ljungqvist, Olle</creatorcontrib><title>A Carbohydrate-Rich Drink Reduces Preoperative Discomfort in Elective Surgery Patients</title><title>Anesthesia and analgesia</title><addtitle>Anesth Analg</addtitle><description>We studied the effects of different preoperative oral fluid protocols on preoperative discomfort, residual gastric fluid volumes, and gastric acidity. Two-hundred-fifty-two elective abdominal surgery patients (ASA physical status I–II) were randomized to preparation with a 12.5% carbohydrate drink (CHO), placebo (flavored water), or overnight fasting. The CHO and Placebo groups were double-blinded and were given 800 mL to drink on the evening before and 400 mL on the morning of surgery. Visual analog scales were used to score 11 different discomfort variables. CHO did not increase gastric fluid volumes or affect acidity, and there were no adverse events. The visual analog scale scores in a control situation were not different between groups. During the waiting period before surgery, the CHO-treated group was less hungry and less anxious than both the other groups (P ≤ 0.05). CHO reduced thirst as effectively as placebo (P < 0.0001 versus Fasted). Trend analysis showed consistently decreasing thirst, hunger, anxiety, malaise, and unfitness in the CHO group (P < 0.05). The Placebo group experienced decreasing unfitness and malaise, whereas nausea, tiredness, and inability to concentrate increased (P < 0.05). In the Fasted group, hunger, thirst, tiredness, weakness, and inability to concentrate increased (P < 0.05). In conclusion, CHO significantly reduces preoperative discomfort without adversely affecting gastric contents.</description><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Cholecystectomy, Laparoscopic</subject><subject>Dietary Carbohydrates - administration & dosage</subject><subject>Double-Blind Method</subject><subject>Elective Surgical Procedures</subject><subject>Fasting</subject><subject>Female</subject><subject>Gastric Acid - metabolism</subject><subject>Gastric Mucosa - metabolism</subject><subject>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>Pain Measurement - drug effects</subject><subject>Placebos</subject><subject>Preoperative Care - methods</subject><issn>0003-2999</issn><issn>1526-7598</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kl1v2yAUhtG0ac26_YWJm-2q3vgwGC6jpPuQKq3qtt4ijA-NF8dkYC_Kvx9p3OYqSAjO4XkPHy8IYUo-UaKrz-TQBNcFI4RSmoMid8lfoBkVTBaV0OolmuUcL5jW-gK9SelPDilR8jW6oFQqVrJqhu7neGFjHVb7JtoBirvWrfAytv0a30EzOkj4NkLYQl5t_wFetsmFjQ9xwG2Prztwj-mfY3yAuMe3mYJ-SG_RK2-7BO-m8RL9_nL9a_GtuPnx9ftiflM4yQQvuCfAuZS1F1RJRxrraqWbWnqf0_kWlFNdW-JVWdUNE1ozJaQvudS25lTwS1Qc66YdbMfabGO7sXFvgm3NlFrnGRihJSM089VZfhtDcxI9CakWSkqWlVdnlcv2fm5CfMh9NLIklcz4xyOeq_4dIQ1mk18Ous72EMZkKsa4YOQAqiPoYkgpgn-uTIk5mG2ezDbPZptHs7P0_bTHWG-gOQkndzPwYQJscrbz0fauTScun5Sy8sCVR24XugFiWnfjDqJZge2GlTn32fh_FX7CLw</recordid><startdate>20011101</startdate><enddate>20011101</enddate><creator>Hausel, Jonatan</creator><creator>Nygren, Jonas</creator><creator>Lagerkranser, Michael</creator><creator>Hellström, Per M.</creator><creator>Hammarqvist, Folke</creator><creator>Almström, Caisa</creator><creator>Lindh, Annika</creator><creator>Thorell, Anders</creator><creator>Ljungqvist, Olle</creator><general>International Anesthesia Research Society</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D91</scope></search><sort><creationdate>20011101</creationdate><title>A Carbohydrate-Rich Drink Reduces Preoperative Discomfort in Elective Surgery Patients</title><author>Hausel, Jonatan ; Nygren, Jonas ; Lagerkranser, Michael ; Hellström, Per M. ; Hammarqvist, Folke ; Almström, Caisa ; Lindh, Annika ; Thorell, Anders ; Ljungqvist, Olle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6253-3f0e3366bf5186c0dacb89db6ff3367591319ba0f847bd25992856f4369ab3153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Cholecystectomy, Laparoscopic</topic><topic>Dietary Carbohydrates - administration & dosage</topic><topic>Double-Blind Method</topic><topic>Elective Surgical Procedures</topic><topic>Fasting</topic><topic>Female</topic><topic>Gastric Acid - metabolism</topic><topic>Gastric Mucosa - metabolism</topic><topic>General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>Pain Measurement - drug effects</topic><topic>Placebos</topic><topic>Preoperative Care - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hausel, Jonatan</creatorcontrib><creatorcontrib>Nygren, Jonas</creatorcontrib><creatorcontrib>Lagerkranser, Michael</creatorcontrib><creatorcontrib>Hellström, Per M.</creatorcontrib><creatorcontrib>Hammarqvist, Folke</creatorcontrib><creatorcontrib>Almström, Caisa</creatorcontrib><creatorcontrib>Lindh, Annika</creatorcontrib><creatorcontrib>Thorell, Anders</creatorcontrib><creatorcontrib>Ljungqvist, Olle</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Örebro universitet</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hausel, Jonatan</au><au>Nygren, Jonas</au><au>Lagerkranser, Michael</au><au>Hellström, Per M.</au><au>Hammarqvist, Folke</au><au>Almström, Caisa</au><au>Lindh, Annika</au><au>Thorell, Anders</au><au>Ljungqvist, Olle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Carbohydrate-Rich Drink Reduces Preoperative Discomfort in Elective Surgery Patients</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>2001-11-01</date><risdate>2001</risdate><volume>93</volume><issue>5</issue><spage>1344</spage><epage>1350</epage><pages>1344-1350</pages><issn>0003-2999</issn><issn>1526-7598</issn><eissn>1526-7598</eissn><coden>AACRAT</coden><abstract>We studied the effects of different preoperative oral fluid protocols on preoperative discomfort, residual gastric fluid volumes, and gastric acidity. Two-hundred-fifty-two elective abdominal surgery patients (ASA physical status I–II) were randomized to preparation with a 12.5% carbohydrate drink (CHO), placebo (flavored water), or overnight fasting. The CHO and Placebo groups were double-blinded and were given 800 mL to drink on the evening before and 400 mL on the morning of surgery. Visual analog scales were used to score 11 different discomfort variables. CHO did not increase gastric fluid volumes or affect acidity, and there were no adverse events. The visual analog scale scores in a control situation were not different between groups. During the waiting period before surgery, the CHO-treated group was less hungry and less anxious than both the other groups (P ≤ 0.05). CHO reduced thirst as effectively as placebo (P < 0.0001 versus Fasted). Trend analysis showed consistently decreasing thirst, hunger, anxiety, malaise, and unfitness in the CHO group (P < 0.05). The Placebo group experienced decreasing unfitness and malaise, whereas nausea, tiredness, and inability to concentrate increased (P < 0.05). In the Fasted group, hunger, thirst, tiredness, weakness, and inability to concentrate increased (P < 0.05). In conclusion, CHO significantly reduces preoperative discomfort without adversely affecting gastric contents.</abstract><cop>Hagerstown, MD</cop><pub>International Anesthesia Research Society</pub><pmid>11682427</pmid><doi>10.1097/00000539-200111000-00063</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Cholecystectomy, Laparoscopic Dietary Carbohydrates - administration & dosage Double-Blind Method Elective Surgical Procedures Fasting Female Gastric Acid - metabolism Gastric Mucosa - metabolism General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation Humans Hydrogen-Ion Concentration Male Medical sciences Medicin och hälsovetenskap Middle Aged Pain Measurement - drug effects Placebos Preoperative Care - methods |
| title | A Carbohydrate-Rich Drink Reduces Preoperative Discomfort in Elective Surgery Patients |
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