Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

Alteration of gene expression is a crucial component of adaptive responses to hypoxia. These responses are mediated by hypoxia-inducible transcription factors (HIFs). Here we describe an inhibitory PAS (Per/Arnt/Sim) domain protein, IPAS, which is a basic helix-loop-helix (bHLH)/PAS protein structur...

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Veröffentlicht in:	Nature (London) 2001-11, Vol.414 (6863), p.550-554
Hauptverfasser:	Poellinger, Lorenz, Makino, Yuichi, Cao, Renhai, Svensson, Kristian, Bertilsson, Göran, Asman, Mikael, Tanaka, Hirotoshi, Cao, Yihai, Berkenstam, Anders
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Aryl Hydrocarbon Receptor Nuclear Translocator Biological and medical sciences Cell Hypoxia Cell metabolism, cell oxidation Cell physiology Cellular biology Cerebellum - metabolism Cornea - metabolism COS Cells DNA-Binding Proteins Endothelial Growth Factors - biosynthesis Endothelial Growth Factors - genetics Fundamental and applied biological sciences. Psychology Gene Expression Regulation Genes HeLa Cells Helix-Loop-Helix Motifs Humanities and Social Sciences Humans Hypoxia Hypoxia-Inducible Factor 1, alpha Subunit IPAS protein letter Lymphokines - biosynthesis Lymphokines - genetics Mice Molecular and cellular biology Molecular Sequence Data multidisciplinary Neovascularization, Physiologic - genetics Neovascularization, Physiologic - physiology Oxygen - metabolism Protein Structure, Tertiary Proteins Receptors, Aryl Hydrocarbon Recombinant Fusion Proteins - genetics Rodents Science Science (multidisciplinary) Sequence Homology, Amino Acid Transcription Factors - biosynthesis Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - metabolism Transcription Factors - physiology Tumor Cells, Cultured Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factors
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