Involvement of spinal N-methyl- d-aspartate receptors in capsaicin-induced in vivo release of substance P in the rat dorsal horn

The aim of the present in vivo microdialysis study was to determine the possible contribution of N-methyl- d-aspartate (NMDA) or α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate (KA) receptors to capsaicin-induced release of substance P-like immunoreactivity (SP-LI) in the dorsal...

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Veröffentlicht in:	Neuroscience letters 2001-12, Vol.316 (2), p.83-86
Hauptverfasser:	Afrah, Abdullahi Warsame, Stiller, Carl-Olav, Olgart, Leif, Brodin, Ernst, Gustafsson, Henrik
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-5-phosphonovalerate - pharmacology Animals Biological and medical sciences Capsaicin Capsaicin - pharmacology Dose-Response Relationship, Drug Excitatory Amino Acid Antagonists - pharmacology Fundamental and applied biological sciences. Psychology Glutamate Glutamic Acid - metabolism Male Medicin och hälsovetenskap Microdialysis Nerve Fibers - drug effects Nerve Fibers - metabolism Nociceptors - drug effects Nociceptors - metabolism Pain Pain - chemically induced Pain - metabolism Pain - physiopathology Posterior Horn Cells - drug effects Posterior Horn Cells - metabolism Quinoxalines - pharmacology Radioimmunoassay Rats Rats, Sprague-Dawley Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal cord Substance P Substance P - metabolism Synapses - drug effects Synapses - metabolism Synaptic Transmission - drug effects Synaptic Transmission - physiology Vertebrates: nervous system and sense organs
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