Influence of solvent exposure and aging on cognitive functioning: an 18 year follow up of formerly exposed floor layers and their controls
Objectives: To extend our knowledge of how exposure to neurotoxic substances during working life affects cognitive functioning in the long term. Does long term occupational exposure to organic solvents lead to aggravated cognitive impairment later in life? Methods: A follow up was conducted of floor...
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| Veröffentlicht in: | Occupational and environmental medicine (London, England) England), 2002-01, Vol.59 (1), p.49-57 |
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| creator | Nilson, L Nordling Sällsten, G Hagberg, S Bäckman, L Barregård, L |
| description | Objectives: To extend our knowledge of how exposure to neurotoxic substances during working life affects cognitive functioning in the long term. Does long term occupational exposure to organic solvents lead to aggravated cognitive impairment later in life? Methods: A follow up was conducted of floor layers exposed to solvents and their unexposed referents (carpenters) 18 years after the baseline assessment. The pattern of cognitive changes in the two groups was compared, with the same 10 neuropsychological tests from the test battery for investigating functional disorders (TUFF) that were used at baseline. The study included 41 floor layers and 40 carpenters. A medical examination focused on health at the present and during the past 18 years. An extensive exposure assessment made in the initial study included questionnaires, interviews, and measurements. Additional exposure during the follow up period was minor, as explored in interviews at follow up. Results: The entire group of floor layers did not deteriorate significantly more over time than did the carpenters. However, among the oldest subjects (>60 years), only floor layers showed decline in visual memory. Moreover, the most highly exposed floor layers deteriorated significantly more than their referents in visual memory and perceptual speed, and they tended to display larger decrements in motor speed. Significant dose effect relations were found; higher cumulative exposure was associated with decrements in visual episodic memory, perceptual speed and attention, and visuospatial skill. Conclusions: The hypothesis that floor layers would deteriorate more in cognitive performance than their unexposed referents over a period of 18 years was partly supported by the results of this study. The results are consistent with the view that the negative effects of exposure to solvents may interact with the normal aging process, primarily at heavy exposure. |
| doi_str_mv | 10.1136/oem.59.1.49 |
| format | Article |
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Does long term occupational exposure to organic solvents lead to aggravated cognitive impairment later in life? Methods: A follow up was conducted of floor layers exposed to solvents and their unexposed referents (carpenters) 18 years after the baseline assessment. The pattern of cognitive changes in the two groups was compared, with the same 10 neuropsychological tests from the test battery for investigating functional disorders (TUFF) that were used at baseline. The study included 41 floor layers and 40 carpenters. A medical examination focused on health at the present and during the past 18 years. An extensive exposure assessment made in the initial study included questionnaires, interviews, and measurements. Additional exposure during the follow up period was minor, as explored in interviews at follow up. Results: The entire group of floor layers did not deteriorate significantly more over time than did the carpenters. However, among the oldest subjects (>60 years), only floor layers showed decline in visual memory. Moreover, the most highly exposed floor layers deteriorated significantly more than their referents in visual memory and perceptual speed, and they tended to display larger decrements in motor speed. Significant dose effect relations were found; higher cumulative exposure was associated with decrements in visual episodic memory, perceptual speed and attention, and visuospatial skill. Conclusions: The hypothesis that floor layers would deteriorate more in cognitive performance than their unexposed referents over a period of 18 years was partly supported by the results of this study. The results are consistent with the view that the negative effects of exposure to solvents may interact with the normal aging process, primarily at heavy exposure.</description><identifier>ISSN: 1351-0711</identifier><identifier>EISSN: 1470-7926</identifier><identifier>DOI: 10.1136/oem.59.1.49</identifier><identifier>PMID: 11836469</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Adhesives ; Adhesives - adverse effects ; Adult ; Age groups ; Aged ; Aging ; Aging - physiology ; Alcoholism ; Alcohols ; Alzheimer's disease ; Analysis of Variance ; Biological and medical sciences ; Brain cancer ; Case-Control Studies ; CEIs ; Central nervous system ; Chemical and industrial products toxicology. Toxic occupational diseases ; Chemical hazards ; chronic toxic encephalopathy ; CNS ; Cognition disorders ; Cognition Disorders - chemically induced ; cognitive ; Cognitive ability ; CTE ; cumulative exposure indices ; Disease ; Dose-response effects ; Exposure ; Floors and Floorcoverings ; Follow-Up Studies ; Glues ; Health aspects ; Humans ; long term follow up ; Longitudinal Studies ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Memory ; Middle Aged ; Neuropsychological Tests ; Neurotoxicity ; Occupational Exposure - adverse effects ; Organic solvents ; Original ; Pearson product-moment correlation ; Perceptual Disorders - chemically induced ; Reasoning ; Referents ; Risk factors ; Solvents ; Solvents - adverse effects ; Sweden ; test battery for investigating functional disorders ; Toxicology ; TUFF</subject><ispartof>Occupational and environmental medicine (London, England), 2002-01, Vol.59 (1), p.49-57</ispartof><rights>Copyright 2002 Occupational and Environmental Medicine</rights><rights>2002 INIST-CNRS</rights><rights>COPYRIGHT 2002 BMJ Publishing Group Ltd.</rights><rights>Copyright: 2002 Copyright 2002 Occupational and Environmental Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b781t-7a703f7df0a2f6d67b69427d7c837e975eb8188ee80a882363c3fdbb773ce7e13</citedby><cites>FETCH-LOGICAL-b781t-7a703f7df0a2f6d67b69427d7c837e975eb8188ee80a882363c3fdbb773ce7e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/27731615$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/27731615$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,552,727,780,784,803,885,4022,27921,27922,27923,53789,53791,58015,58248</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13401131$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11836469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:18035361$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Nilson, L Nordling</creatorcontrib><creatorcontrib>Sällsten, G</creatorcontrib><creatorcontrib>Hagberg, S</creatorcontrib><creatorcontrib>Bäckman, L</creatorcontrib><creatorcontrib>Barregård, L</creatorcontrib><title>Influence of solvent exposure and aging on cognitive functioning: an 18 year follow up of formerly exposed floor layers and their controls</title><title>Occupational and environmental medicine (London, England)</title><addtitle>Occup Environ Med</addtitle><description>Objectives: To extend our knowledge of how exposure to neurotoxic substances during working life affects cognitive functioning in the long term. Does long term occupational exposure to organic solvents lead to aggravated cognitive impairment later in life? Methods: A follow up was conducted of floor layers exposed to solvents and their unexposed referents (carpenters) 18 years after the baseline assessment. The pattern of cognitive changes in the two groups was compared, with the same 10 neuropsychological tests from the test battery for investigating functional disorders (TUFF) that were used at baseline. The study included 41 floor layers and 40 carpenters. A medical examination focused on health at the present and during the past 18 years. An extensive exposure assessment made in the initial study included questionnaires, interviews, and measurements. Additional exposure during the follow up period was minor, as explored in interviews at follow up. Results: The entire group of floor layers did not deteriorate significantly more over time than did the carpenters. However, among the oldest subjects (>60 years), only floor layers showed decline in visual memory. Moreover, the most highly exposed floor layers deteriorated significantly more than their referents in visual memory and perceptual speed, and they tended to display larger decrements in motor speed. Significant dose effect relations were found; higher cumulative exposure was associated with decrements in visual episodic memory, perceptual speed and attention, and visuospatial skill. Conclusions: The hypothesis that floor layers would deteriorate more in cognitive performance than their unexposed referents over a period of 18 years was partly supported by the results of this study. The results are consistent with the view that the negative effects of exposure to solvents may interact with the normal aging process, primarily at heavy exposure.</description><subject>Adhesives</subject><subject>Adhesives - adverse effects</subject><subject>Adult</subject><subject>Age groups</subject><subject>Aged</subject><subject>Aging</subject><subject>Aging - physiology</subject><subject>Alcoholism</subject><subject>Alcohols</subject><subject>Alzheimer's disease</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Brain cancer</subject><subject>Case-Control Studies</subject><subject>CEIs</subject><subject>Central nervous system</subject><subject>Chemical and industrial products toxicology. 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Sällsten, G ; Hagberg, S ; Bäckman, L ; Barregård, L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b781t-7a703f7df0a2f6d67b69427d7c837e975eb8188ee80a882363c3fdbb773ce7e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adhesives</topic><topic>Adhesives - adverse effects</topic><topic>Adult</topic><topic>Age groups</topic><topic>Aged</topic><topic>Aging</topic><topic>Aging - physiology</topic><topic>Alcoholism</topic><topic>Alcohols</topic><topic>Alzheimer's disease</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Brain cancer</topic><topic>Case-Control Studies</topic><topic>CEIs</topic><topic>Central nervous system</topic><topic>Chemical and industrial products toxicology. 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Does long term occupational exposure to organic solvents lead to aggravated cognitive impairment later in life? Methods: A follow up was conducted of floor layers exposed to solvents and their unexposed referents (carpenters) 18 years after the baseline assessment. The pattern of cognitive changes in the two groups was compared, with the same 10 neuropsychological tests from the test battery for investigating functional disorders (TUFF) that were used at baseline. The study included 41 floor layers and 40 carpenters. A medical examination focused on health at the present and during the past 18 years. An extensive exposure assessment made in the initial study included questionnaires, interviews, and measurements. Additional exposure during the follow up period was minor, as explored in interviews at follow up. Results: The entire group of floor layers did not deteriorate significantly more over time than did the carpenters. However, among the oldest subjects (>60 years), only floor layers showed decline in visual memory. Moreover, the most highly exposed floor layers deteriorated significantly more than their referents in visual memory and perceptual speed, and they tended to display larger decrements in motor speed. Significant dose effect relations were found; higher cumulative exposure was associated with decrements in visual episodic memory, perceptual speed and attention, and visuospatial skill. Conclusions: The hypothesis that floor layers would deteriorate more in cognitive performance than their unexposed referents over a period of 18 years was partly supported by the results of this study. The results are consistent with the view that the negative effects of exposure to solvents may interact with the normal aging process, primarily at heavy exposure.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>11836469</pmid><doi>10.1136/oem.59.1.49</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1351-0711 |
| ispartof | Occupational and environmental medicine (London, England), 2002-01, Vol.59 (1), p.49-57 |
| issn | 1351-0711 1470-7926 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_595238 |
| source | MEDLINE; SWEPUB Freely available online; JSTOR Archive Collection A-Z Listing; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adhesives Adhesives - adverse effects Adult Age groups Aged Aging Aging - physiology Alcoholism Alcohols Alzheimer's disease Analysis of Variance Biological and medical sciences Brain cancer Case-Control Studies CEIs Central nervous system Chemical and industrial products toxicology. Toxic occupational diseases Chemical hazards chronic toxic encephalopathy CNS Cognition disorders Cognition Disorders - chemically induced cognitive Cognitive ability CTE cumulative exposure indices Disease Dose-response effects Exposure Floors and Floorcoverings Follow-Up Studies Glues Health aspects Humans long term follow up Longitudinal Studies Male Medical sciences Medicin och hälsovetenskap Memory Middle Aged Neuropsychological Tests Neurotoxicity Occupational Exposure - adverse effects Organic solvents Original Pearson product-moment correlation Perceptual Disorders - chemically induced Reasoning Referents Risk factors Solvents Solvents - adverse effects Sweden test battery for investigating functional disorders Toxicology TUFF |
| title | Influence of solvent exposure and aging on cognitive functioning: an 18 year follow up of formerly exposed floor layers and their controls |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T20%3A02%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Influence%20of%20solvent%20exposure%20and%20aging%20on%20cognitive%20functioning:%20an%2018%20year%20follow%20up%20of%20formerly%20exposed%20floor%20layers%20and%20their%20controls&rft.jtitle=Occupational%20and%20environmental%20medicine%20(London,%20England)&rft.au=Nilson,%20L%20Nordling&rft.date=2002-01&rft.volume=59&rft.issue=1&rft.spage=49&rft.epage=57&rft.pages=49-57&rft.issn=1351-0711&rft.eissn=1470-7926&rft_id=info:doi/10.1136/oem.59.1.49&rft_dat=%3Cgale_swepu%3EA82321744%3C/gale_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1781526768&rft_id=info:pmid/11836469&rft_galeid=A82321744&rft_jstor_id=27731615&rfr_iscdi=true |