Cardiac and vascular structure and function are related to lipid peroxidation and metabolism
The present study investigated possible relationships between left ventricular mass, intima‐media thickness of the carotid artery (IMT), total arterial compliance, and lipid status in a population sample of 58 apparently healthy subjects aged 20 to 69. By stepwise multiple regression analysis, inclu...
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| Veröffentlicht in: | Lipids 2002-03, Vol.37 (3), p.231-236 |
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| creator | Steer, Peter Millgård, Jonas Sarabi, Dennis M. Basu, Samar Vessby, Bengt Kahan, Thomas Edner, Magnus Lind, Lars |
| description | The present study investigated possible relationships between left ventricular mass, intima‐media thickness of the carotid artery (IMT), total arterial compliance, and lipid status in a population sample of 58 apparently healthy subjects aged 20 to 69. By stepwise multiple regression analysis, including age, blood pressure, and smoking, left ventricular mass index, measured by M‐mode echocardiography, increased by 13.0 g/m2 for each 1 standard deviation (SD=0.11 μM, r=0.60, P |
| doi_str_mv | 10.1007/s11745-002-0885-3 |
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By stepwise multiple regression analysis, including age, blood pressure, and smoking, left ventricular mass index, measured by M‐mode echocardiography, increased by 13.0 g/m2 for each 1 standard deviation (SD=0.11 μM, r=0.60, P<0.01) increase in plasma malondialdehyde and 9.50 g/m2 per SD increase in plasma 8‐iso‐prostaglandin F2α in women only (SD=8.88 ng/L, r=0.44, P=0.01). Each 1‐SD (SD=0.27 g/L) increase in apolipoprotein B was associated with a 63 μm increase in IMT (r=0.47, P=0.01) and a 0.27 mL/min/m2/mm Hg (r=−0.60, P<0.01) decrease in stroke index/pulse pressure ratio, reflecting total arterial compliance in women. In men, each 1‐SD increase in the proportion of stearic acid (18∶0) in serum cholesterol esters (SD=0.12 percent units) reduced the transmitral E/A ratio, measured by Doppler echocardiography, reflecting left ventricular diastolic function, by 0.10 units (r=−0.29, P<0.05). Thus, important cardiovascular characteristics, such as left ventricular mass, left ventricular diastolic function, carotid IMT, and total arterial compliance, were independently predicted by indices of lipid metabolism and peroxidation in apparently healthy subjects.</description><identifier>ISSN: 0024-4201</identifier><identifier>ISSN: 1558-9307</identifier><identifier>EISSN: 1558-9307</identifier><identifier>DOI: 10.1007/s11745-002-0885-3</identifier><identifier>PMID: 11942472</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer‐Verlag</publisher><subject>Adult ; Aged ; Blood pressure ; Blood Vessels - anatomy & histology ; Blood Vessels - metabolism ; Blood Vessels - physiology ; Blood Vessels/anatomy & histology/metabolism/physiology ; Compliance ; Drug therapy ; Esters ; Heart - anatomy & histology ; Heart - physiology ; Heart/anatomy & histology/physiology ; Humans ; Lipid Peroxidation ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; Middle Aged ; Peroxidation ; Reference Values ; Regression analysis ; Standard deviation ; Studies</subject><ispartof>Lipids, 2002-03, Vol.37 (3), p.231-236</ispartof><rights>2002 American Oil Chemists' Society (AOCS)</rights><rights>AOCS Press 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4941-b9f8ea1cbc12cb08e3f308db0383c8bb8f9a85bb1cc674333dfa5bed93c057443</citedby><cites>FETCH-LOGICAL-c4941-b9f8ea1cbc12cb08e3f308db0383c8bb8f9a85bb1cc674333dfa5bed93c057443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1007%2Fs11745-002-0885-3$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1007%2Fs11745-002-0885-3$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,781,785,886,1418,27926,27927,45576,45577</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11942472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-73183$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1946564$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Steer, Peter</creatorcontrib><creatorcontrib>Millgård, Jonas</creatorcontrib><creatorcontrib>Sarabi, Dennis M.</creatorcontrib><creatorcontrib>Basu, Samar</creatorcontrib><creatorcontrib>Vessby, Bengt</creatorcontrib><creatorcontrib>Kahan, Thomas</creatorcontrib><creatorcontrib>Edner, Magnus</creatorcontrib><creatorcontrib>Lind, Lars</creatorcontrib><title>Cardiac and vascular structure and function are related to lipid peroxidation and metabolism</title><title>Lipids</title><addtitle>Lipids</addtitle><description>The present study investigated possible relationships between left ventricular mass, intima‐media thickness of the carotid artery (IMT), total arterial compliance, and lipid status in a population sample of 58 apparently healthy subjects aged 20 to 69. 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Thus, important cardiovascular characteristics, such as left ventricular mass, left ventricular diastolic function, carotid IMT, and total arterial compliance, were independently predicted by indices of lipid metabolism and peroxidation in apparently healthy subjects.</description><subject>Adult</subject><subject>Aged</subject><subject>Blood pressure</subject><subject>Blood Vessels - anatomy & histology</subject><subject>Blood Vessels - metabolism</subject><subject>Blood Vessels - physiology</subject><subject>Blood Vessels/anatomy & histology/metabolism/physiology</subject><subject>Compliance</subject><subject>Drug therapy</subject><subject>Esters</subject><subject>Heart - anatomy & histology</subject><subject>Heart - physiology</subject><subject>Heart/anatomy & histology/physiology</subject><subject>Humans</subject><subject>Lipid Peroxidation</subject><subject>MEDICIN</subject><subject>Medicin och hälsovetenskap</subject><subject>MEDICINE</subject><subject>Middle Aged</subject><subject>Peroxidation</subject><subject>Reference Values</subject><subject>Regression analysis</subject><subject>Standard deviation</subject><subject>Studies</subject><issn>0024-4201</issn><issn>1558-9307</issn><issn>1558-9307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFks1u1DAUhS0EotPCA7BBEQs2KOAb22NnWU2hVBoJFsAKyfJfkEsSBztu6dvjkIGRkCpWtq-_c651fRB6Bvg1YMzfJABOWY1xU2MhWE0eoA0wJuqWYP4QbcoFrWmD4QSdpnRdjkBb9hidALS0obzZoK87Fa1XplKjrW5UMrlXsUpzzGbO0f0ud3k0sw9jpUohul7NzlZzqHo_eVtNLoaf3qqVKPjgZqVD79PwBD3qVJ_c08N6hj6_e_tp977ef7i82p3va0NbCrVuO-EUGG2gMRoLRzqChdWYCGKE1qJrlWBagzFbTgkhtlNMO9sSgxmnlJyhevVNt27KWk7RDyreyaC8PJS-l52TrKUMk8Lze_kpBnsU_RGWeW3Zdun06l7lhf9yLkP8JnOWnIBY-rxc6WL6I7s0y8En4_pejS7kJDmwFgtYbF_8A16HHMcyMymEAEJZAwWCFTIxpBRd97c7YLnkQa55kOWf5ZIHubzg-cE468HZo-IQgOMobn3v7v7vKPdXHy9wQ4D8Amraw50</recordid><startdate>200203</startdate><enddate>200203</enddate><creator>Steer, Peter</creator><creator>Millgård, Jonas</creator><creator>Sarabi, Dennis M.</creator><creator>Basu, Samar</creator><creator>Vessby, Bengt</creator><creator>Kahan, Thomas</creator><creator>Edner, Magnus</creator><creator>Lind, Lars</creator><general>Springer‐Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P64</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DF2</scope></search><sort><creationdate>200203</creationdate><title>Cardiac and vascular structure and function are related to lipid peroxidation and metabolism</title><author>Steer, Peter ; Millgård, Jonas ; Sarabi, Dennis M. ; Basu, Samar ; Vessby, Bengt ; Kahan, Thomas ; Edner, Magnus ; Lind, Lars</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4941-b9f8ea1cbc12cb08e3f308db0383c8bb8f9a85bb1cc674333dfa5bed93c057443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Blood pressure</topic><topic>Blood Vessels - 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Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Uppsala universitet</collection><jtitle>Lipids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steer, Peter</au><au>Millgård, Jonas</au><au>Sarabi, Dennis M.</au><au>Basu, Samar</au><au>Vessby, Bengt</au><au>Kahan, Thomas</au><au>Edner, Magnus</au><au>Lind, Lars</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac and vascular structure and function are related to lipid peroxidation and metabolism</atitle><jtitle>Lipids</jtitle><addtitle>Lipids</addtitle><date>2002-03</date><risdate>2002</risdate><volume>37</volume><issue>3</issue><spage>231</spage><epage>236</epage><pages>231-236</pages><issn>0024-4201</issn><issn>1558-9307</issn><eissn>1558-9307</eissn><abstract>The present study investigated possible relationships between left ventricular mass, intima‐media thickness of the carotid artery (IMT), total arterial compliance, and lipid status in a population sample of 58 apparently healthy subjects aged 20 to 69. By stepwise multiple regression analysis, including age, blood pressure, and smoking, left ventricular mass index, measured by M‐mode echocardiography, increased by 13.0 g/m2 for each 1 standard deviation (SD=0.11 μM, r=0.60, P<0.01) increase in plasma malondialdehyde and 9.50 g/m2 per SD increase in plasma 8‐iso‐prostaglandin F2α in women only (SD=8.88 ng/L, r=0.44, P=0.01). Each 1‐SD (SD=0.27 g/L) increase in apolipoprotein B was associated with a 63 μm increase in IMT (r=0.47, P=0.01) and a 0.27 mL/min/m2/mm Hg (r=−0.60, P<0.01) decrease in stroke index/pulse pressure ratio, reflecting total arterial compliance in women. In men, each 1‐SD increase in the proportion of stearic acid (18∶0) in serum cholesterol esters (SD=0.12 percent units) reduced the transmitral E/A ratio, measured by Doppler echocardiography, reflecting left ventricular diastolic function, by 0.10 units (r=−0.29, P<0.05). Thus, important cardiovascular characteristics, such as left ventricular mass, left ventricular diastolic function, carotid IMT, and total arterial compliance, were independently predicted by indices of lipid metabolism and peroxidation in apparently healthy subjects.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer‐Verlag</pub><pmid>11942472</pmid><doi>10.1007/s11745-002-0885-3</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Blood pressure Blood Vessels - anatomy & histology Blood Vessels - metabolism Blood Vessels - physiology Blood Vessels/anatomy & histology/metabolism/physiology Compliance Drug therapy Esters Heart - anatomy & histology Heart - physiology Heart/anatomy & histology/physiology Humans Lipid Peroxidation MEDICIN Medicin och hälsovetenskap MEDICINE Middle Aged Peroxidation Reference Values Regression analysis Standard deviation Studies |
| title | Cardiac and vascular structure and function are related to lipid peroxidation and metabolism |
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