Characterization of the p53-rescue drug CP-31398 in vitro and in living cells

The Pfizer compound CP-31398 has been reported to stabilize the core domain of the tumour suppressor p53 in vitro and be an effective anti-cancer drug by virtue of rescuing destabilized mutants of p53. We did not detect any interaction between the p53 core domain and CP-31398 in vitro by a wide rang...

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Veröffentlicht in:	Oncogene 2002-03, Vol.21 (14), p.2119-2129
Hauptverfasser:	RIPPIN, Thomas M, BYKOV, Vladimir J. N, FREUND, Stefan M. V, SELIVANOVA, Galina, WIMAN, Klas G, FERSHT, Alan R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor agents Biological and medical sciences Calorimetry, Differential Scanning Cancer Cell Division - drug effects Cell physiology Cell Survival - drug effects Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Chemotherapy Cycloheximide Deoxyribonucleic acid DNA DNA - genetics DNA - metabolism Drug Stability Epitopes Fundamental and applied biological sciences. Psychology Genes, p53 - genetics Humans Laboratories Mass Spectrometry Medical sciences Medicin och hälsovetenskap Microscopy, Fluorescence Models, Molecular Molecular and cellular biology Mutants Mutation NMR Nuclear magnetic resonance Nuclear Magnetic Resonance, Biomolecular Nucleotide sequence p53 Protein Pharmacology. Drug treatments Protein Binding - drug effects Protein Conformation - drug effects Protein Denaturation - drug effects Pyrimidines - chemistry Pyrimidines - pharmacology Temperature Tumor Cells, Cultured Tumor suppressor genes Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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