D-Methionine and cisplatin ototoxicity in the guinea pig: D-methionine influences cisplatin pharmacokinetics
D-Methionine has recently been advocated as a protectant against cisplatin toxicity. The use of systemic D-methionine as a protector was studied in 58 guinea pigs. Kinetics and distribution of [ 11CH 3] D-methionine was analysed by positron emission tomography. Cisplatin and the monohydrated complex...
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| Veröffentlicht in: | Hearing research 2002-03, Vol.165 (1), p.53-61 |
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| creator | Ekborn, Andreas Laurell, Göran Johnström, Peter Wallin, Inger Eksborg, Staffan Ehrsson, Hans |
| description | D-Methionine has recently been advocated as a protectant against cisplatin toxicity. The use of systemic
D-methionine as a protector was studied in 58 guinea pigs. Kinetics and distribution of [
11CH
3]
D-methionine was analysed by positron emission tomography. Cisplatin and the monohydrated complex of cisplatin was quantified in blood ultrafiltrate using reversed-phase liquid chromatography with post-column derivatisation. Administration of 300 mg/kg of
D-methionine caused a 30% decrease in the area under the concentration–time curve (AUC) of cisplatin. The toxic effect of cisplatin was studied after dose adjustment of cisplatin, i.e. with similar cisplatin AUC in the group receiving
D-methionine and the saline control group. A significant ototoxic effect, measured as difference in pre- and 96 h post-treatment electrophysiological hearing threshold (auditory brainstem response), was observed at stimulus frequencies of 30 and 20 kHz. There was no difference between the groups in the extent of threshold shift. Quantitative outer hair cell counts showed a similar loss of cells in the two groups. All animals had a significant increase in plasma-creatinine but there was no difference between the groups. The results indicate that protection from cisplatin ototoxicity by systemic
D-methionine can be explained by a lowered systemic exposure to the drug. |
| doi_str_mv | 10.1016/S0378-5955(02)00277-0 |
| format | Article |
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D-methionine as a protector was studied in 58 guinea pigs. Kinetics and distribution of [
11CH
3]
D-methionine was analysed by positron emission tomography. Cisplatin and the monohydrated complex of cisplatin was quantified in blood ultrafiltrate using reversed-phase liquid chromatography with post-column derivatisation. Administration of 300 mg/kg of
D-methionine caused a 30% decrease in the area under the concentration–time curve (AUC) of cisplatin. The toxic effect of cisplatin was studied after dose adjustment of cisplatin, i.e. with similar cisplatin AUC in the group receiving
D-methionine and the saline control group. A significant ototoxic effect, measured as difference in pre- and 96 h post-treatment electrophysiological hearing threshold (auditory brainstem response), was observed at stimulus frequencies of 30 and 20 kHz. There was no difference between the groups in the extent of threshold shift. Quantitative outer hair cell counts showed a similar loss of cells in the two groups. All animals had a significant increase in plasma-creatinine but there was no difference between the groups. The results indicate that protection from cisplatin ototoxicity by systemic
D-methionine can be explained by a lowered systemic exposure to the drug.</description><identifier>ISSN: 0378-5955</identifier><identifier>EISSN: 1878-5891</identifier><identifier>DOI: 10.1016/S0378-5955(02)00277-0</identifier><identifier>PMID: 12031515</identifier><identifier>CODEN: HERED3</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; Antineoplastic Agents - pharmacokinetics ; Antineoplastic Agents - poisoning ; Biological and medical sciences ; Body Weight - drug effects ; Cisplatin ; Cisplatin - pharmacokinetics ; Cisplatin - poisoning ; Creatine - metabolism ; Cytoprotection ; D-Methionine ; Drug toxicity and drugs side effects treatment ; Ear ; Evoked Potentials, Auditory, Brain Stem - drug effects ; Female ; Guinea Pigs ; Kidney - drug effects ; Kidney - metabolism ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Methionine - pharmacology ; Nephrotoxicity ; Ototoxicity ; Pharmacokinetics ; Pharmacology. Drug treatments ; Positron emission tomography ; Tissue Distribution ; Tomography, Emission-Computed ; Toxicity: respiratory system, ent, stomatology</subject><ispartof>Hearing research, 2002-03, Vol.165 (1), p.53-61</ispartof><rights>2002 Elsevier Science B.V.</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c543t-3c969e92646185084f7cb3b98ef7b3cdaf491f7a68568bbd8d44afaa0991e7553</citedby><cites>FETCH-LOGICAL-c543t-3c969e92646185084f7cb3b98ef7b3cdaf491f7a68568bbd8d44afaa0991e7553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0378-5955(02)00277-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13668065$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12031515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1946715$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Ekborn, Andreas</creatorcontrib><creatorcontrib>Laurell, Göran</creatorcontrib><creatorcontrib>Johnström, Peter</creatorcontrib><creatorcontrib>Wallin, Inger</creatorcontrib><creatorcontrib>Eksborg, Staffan</creatorcontrib><creatorcontrib>Ehrsson, Hans</creatorcontrib><title>D-Methionine and cisplatin ototoxicity in the guinea pig: D-methionine influences cisplatin pharmacokinetics</title><title>Hearing research</title><addtitle>Hear Res</addtitle><description>D-Methionine has recently been advocated as a protectant against cisplatin toxicity. The use of systemic
D-methionine as a protector was studied in 58 guinea pigs. Kinetics and distribution of [
11CH
3]
D-methionine was analysed by positron emission tomography. Cisplatin and the monohydrated complex of cisplatin was quantified in blood ultrafiltrate using reversed-phase liquid chromatography with post-column derivatisation. Administration of 300 mg/kg of
D-methionine caused a 30% decrease in the area under the concentration–time curve (AUC) of cisplatin. The toxic effect of cisplatin was studied after dose adjustment of cisplatin, i.e. with similar cisplatin AUC in the group receiving
D-methionine and the saline control group. A significant ototoxic effect, measured as difference in pre- and 96 h post-treatment electrophysiological hearing threshold (auditory brainstem response), was observed at stimulus frequencies of 30 and 20 kHz. There was no difference between the groups in the extent of threshold shift. Quantitative outer hair cell counts showed a similar loss of cells in the two groups. All animals had a significant increase in plasma-creatinine but there was no difference between the groups. The results indicate that protection from cisplatin ototoxicity by systemic
D-methionine can be explained by a lowered systemic exposure to the drug.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacokinetics</subject><subject>Antineoplastic Agents - poisoning</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Cisplatin</subject><subject>Cisplatin - pharmacokinetics</subject><subject>Cisplatin - poisoning</subject><subject>Creatine - metabolism</subject><subject>Cytoprotection</subject><subject>D-Methionine</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Ear</subject><subject>Evoked Potentials, Auditory, Brain Stem - drug effects</subject><subject>Female</subject><subject>Guinea Pigs</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Methionine - pharmacology</subject><subject>Nephrotoxicity</subject><subject>Ototoxicity</subject><subject>Pharmacokinetics</subject><subject>Pharmacology. Drug treatments</subject><subject>Positron emission tomography</subject><subject>Tissue Distribution</subject><subject>Tomography, Emission-Computed</subject><subject>Toxicity: respiratory system, ent, stomatology</subject><issn>0378-5955</issn><issn>1878-5891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctOxCAUhonROOPlETTdmOiiCqXc3BjjPRnjQl0TSmEGp9M20PHy9lJndNwYwwI4-b4DOT8AewgeI4joySPEjKdEEHIIsyMIM8ZSuAaGiPdlLtA6GP4gA7AVwguEiOA82wQDlEGMCCJDUF2m96abuKZ2tUlUXSbahbZSnauTpovr3WnXfSTx2k1MMp5HTCWtG58ml-lsZbraVnNTaxN-NWgnys-UbqaR6JwOO2DDqiqY3eW-DZ6vr54ubtPRw83dxfko1STHXYq1oMKIjOYUcQJ5bpkucCG4sazAulQ2F8gyRTmhvChKXua5skpBIZBhhOBtkC76hjfTzgvZejdT_kM2ysllaRpPRhKBRU4jz_7kW9-UK-lbRFFjqH-JLEztmxC8sT8ugrLPSX7lJPsQJMzkV04SRm9_4cW2M1OurGUwEThYAipoVVmv6jjXFYcp5ZD23NmCM3Ger854GbTrcyidN7qTZeP--conYk2zCA</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Ekborn, Andreas</creator><creator>Laurell, Göran</creator><creator>Johnström, Peter</creator><creator>Wallin, Inger</creator><creator>Eksborg, Staffan</creator><creator>Ehrsson, Hans</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20020301</creationdate><title>D-Methionine and cisplatin ototoxicity in the guinea pig: D-methionine influences cisplatin pharmacokinetics</title><author>Ekborn, Andreas ; Laurell, Göran ; Johnström, Peter ; Wallin, Inger ; Eksborg, Staffan ; Ehrsson, Hans</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c543t-3c969e92646185084f7cb3b98ef7b3cdaf491f7a68568bbd8d44afaa0991e7553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacokinetics</topic><topic>Antineoplastic Agents - poisoning</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Cisplatin</topic><topic>Cisplatin - pharmacokinetics</topic><topic>Cisplatin - poisoning</topic><topic>Creatine - metabolism</topic><topic>Cytoprotection</topic><topic>D-Methionine</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Ear</topic><topic>Evoked Potentials, Auditory, Brain Stem - drug effects</topic><topic>Female</topic><topic>Guinea Pigs</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Methionine - pharmacology</topic><topic>Nephrotoxicity</topic><topic>Ototoxicity</topic><topic>Pharmacokinetics</topic><topic>Pharmacology. Drug treatments</topic><topic>Positron emission tomography</topic><topic>Tissue Distribution</topic><topic>Tomography, Emission-Computed</topic><topic>Toxicity: respiratory system, ent, stomatology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ekborn, Andreas</creatorcontrib><creatorcontrib>Laurell, Göran</creatorcontrib><creatorcontrib>Johnström, Peter</creatorcontrib><creatorcontrib>Wallin, Inger</creatorcontrib><creatorcontrib>Eksborg, Staffan</creatorcontrib><creatorcontrib>Ehrsson, Hans</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Hearing research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ekborn, Andreas</au><au>Laurell, Göran</au><au>Johnström, Peter</au><au>Wallin, Inger</au><au>Eksborg, Staffan</au><au>Ehrsson, Hans</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>D-Methionine and cisplatin ototoxicity in the guinea pig: D-methionine influences cisplatin pharmacokinetics</atitle><jtitle>Hearing research</jtitle><addtitle>Hear Res</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>165</volume><issue>1</issue><spage>53</spage><epage>61</epage><pages>53-61</pages><issn>0378-5955</issn><eissn>1878-5891</eissn><coden>HERED3</coden><abstract>D-Methionine has recently been advocated as a protectant against cisplatin toxicity. The use of systemic
D-methionine as a protector was studied in 58 guinea pigs. Kinetics and distribution of [
11CH
3]
D-methionine was analysed by positron emission tomography. Cisplatin and the monohydrated complex of cisplatin was quantified in blood ultrafiltrate using reversed-phase liquid chromatography with post-column derivatisation. Administration of 300 mg/kg of
D-methionine caused a 30% decrease in the area under the concentration–time curve (AUC) of cisplatin. The toxic effect of cisplatin was studied after dose adjustment of cisplatin, i.e. with similar cisplatin AUC in the group receiving
D-methionine and the saline control group. A significant ototoxic effect, measured as difference in pre- and 96 h post-treatment electrophysiological hearing threshold (auditory brainstem response), was observed at stimulus frequencies of 30 and 20 kHz. There was no difference between the groups in the extent of threshold shift. Quantitative outer hair cell counts showed a similar loss of cells in the two groups. All animals had a significant increase in plasma-creatinine but there was no difference between the groups. The results indicate that protection from cisplatin ototoxicity by systemic
D-methionine can be explained by a lowered systemic exposure to the drug.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>12031515</pmid><doi>10.1016/S0378-5955(02)00277-0</doi><tpages>9</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - poisoning Biological and medical sciences Body Weight - drug effects Cisplatin Cisplatin - pharmacokinetics Cisplatin - poisoning Creatine - metabolism Cytoprotection D-Methionine Drug toxicity and drugs side effects treatment Ear Evoked Potentials, Auditory, Brain Stem - drug effects Female Guinea Pigs Kidney - drug effects Kidney - metabolism Male Medical sciences Medicin och hälsovetenskap Methionine - pharmacology Nephrotoxicity Ototoxicity Pharmacokinetics Pharmacology. Drug treatments Positron emission tomography Tissue Distribution Tomography, Emission-Computed Toxicity: respiratory system, ent, stomatology |
| title | D-Methionine and cisplatin ototoxicity in the guinea pig: D-methionine influences cisplatin pharmacokinetics |
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