Estrogen receptor-alpha and -beta are expressed throughout postnatal development in the rat and rabbit growth plate
Estrogen regulates skeletal growth and promotes epiphyseal fusion. To explore the mechanisms underlying these effects we investigated the expression of estrogen receptor-alpha (ERalpha) and -beta (ERbeta) in rat and rabbit growth plates during postnatal development, using immunohistochemistry. Immun...
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| Veröffentlicht in: | Journal of endocrinology 2002-06, Vol.173 (3), p.407-414 |
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| creator | Nilsson, O Abad, V Chrysis, D Ritzen, EM Savendahl, L Baron, J |
| description | Estrogen regulates skeletal growth and promotes epiphyseal fusion. To explore the mechanisms underlying these effects we investigated the expression of estrogen receptor-alpha (ERalpha) and -beta (ERbeta) in rat and rabbit growth plates during postnatal development, using immunohistochemistry. Immunoreactivity for ERalpha and ERbeta was observed in resting zone and proliferative zone chondrocytes at all ages studied for both rat (7, 14, 28 and 70 days of age) and rabbit (1, 7, 28 and 120 days of age). In the rat distal humerus and the rabbit proximal tibia, expression of both receptors in the hypertrophic zone was minimal at early ages, increasing only at the last time point prior to epiphyseal fusion. Expression was rarely seen in the hypertrophic zone of the rat proximal tibia, a growth plate that does not fuse until late in life. Therefore, we conclude that ERalpha and ERbeta are both expressed in the mammalian growth plate. The temporal and anatomical pattern suggests that ER expression in the hypertrophic zone in particular may play a role in epiphyseal fusion. |
| doi_str_mv | 10.1677/joe.0.1730407 |
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To explore the mechanisms underlying these effects we investigated the expression of estrogen receptor-alpha (ERalpha) and -beta (ERbeta) in rat and rabbit growth plates during postnatal development, using immunohistochemistry. Immunoreactivity for ERalpha and ERbeta was observed in resting zone and proliferative zone chondrocytes at all ages studied for both rat (7, 14, 28 and 70 days of age) and rabbit (1, 7, 28 and 120 days of age). In the rat distal humerus and the rabbit proximal tibia, expression of both receptors in the hypertrophic zone was minimal at early ages, increasing only at the last time point prior to epiphyseal fusion. Expression was rarely seen in the hypertrophic zone of the rat proximal tibia, a growth plate that does not fuse until late in life. Therefore, we conclude that ERalpha and ERbeta are both expressed in the mammalian growth plate. The temporal and anatomical pattern suggests that ER expression in the hypertrophic zone in particular may play a role in epiphyseal fusion.</description><identifier>ISSN: 0022-0795</identifier><identifier>EISSN: 1479-6805</identifier><identifier>DOI: 10.1677/joe.0.1730407</identifier><identifier>PMID: 12065230</identifier><identifier>CODEN: JOENAK</identifier><language>eng</language><publisher>Colchester: BioScientifica</publisher><subject>Aging - physiology ; Animals ; Biological and medical sciences ; Chondrocytes - chemistry ; Chondrocytes - metabolism ; Estrogen Receptor alpha ; Estrogen Receptor beta ; Female ; Fundamental and applied biological sciences. Psychology ; Growth Plate - chemistry ; Growth Plate - metabolism ; Humerus ; Immunohistochemistry - methods ; Male ; Medicin och hälsovetenskap ; Rabbits ; Rats ; Rats, Sprague-Dawley ; Receptors, Estrogen - analysis ; Receptors, Estrogen - metabolism ; Skeleton and joints ; Tibia ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Journal of endocrinology, 2002-06, Vol.173 (3), p.407-414</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b599t-1a395c47fc358906be3b99405102147debe7dd33265a96870ee269d0436c1b8e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13725540$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12065230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1936853$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Nilsson, O</creatorcontrib><creatorcontrib>Abad, V</creatorcontrib><creatorcontrib>Chrysis, D</creatorcontrib><creatorcontrib>Ritzen, EM</creatorcontrib><creatorcontrib>Savendahl, L</creatorcontrib><creatorcontrib>Baron, J</creatorcontrib><title>Estrogen receptor-alpha and -beta are expressed throughout postnatal development in the rat and rabbit growth plate</title><title>Journal of endocrinology</title><addtitle>J Endocrinol</addtitle><description>Estrogen regulates skeletal growth and promotes epiphyseal fusion. To explore the mechanisms underlying these effects we investigated the expression of estrogen receptor-alpha (ERalpha) and -beta (ERbeta) in rat and rabbit growth plates during postnatal development, using immunohistochemistry. Immunoreactivity for ERalpha and ERbeta was observed in resting zone and proliferative zone chondrocytes at all ages studied for both rat (7, 14, 28 and 70 days of age) and rabbit (1, 7, 28 and 120 days of age). In the rat distal humerus and the rabbit proximal tibia, expression of both receptors in the hypertrophic zone was minimal at early ages, increasing only at the last time point prior to epiphyseal fusion. Expression was rarely seen in the hypertrophic zone of the rat proximal tibia, a growth plate that does not fuse until late in life. Therefore, we conclude that ERalpha and ERbeta are both expressed in the mammalian growth plate. The temporal and anatomical pattern suggests that ER expression in the hypertrophic zone in particular may play a role in epiphyseal fusion.</description><subject>Aging - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chondrocytes - chemistry</subject><subject>Chondrocytes - metabolism</subject><subject>Estrogen Receptor alpha</subject><subject>Estrogen Receptor beta</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Growth Plate - chemistry</subject><subject>Growth Plate - metabolism</subject><subject>Humerus</subject><subject>Immunohistochemistry - methods</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, Estrogen - analysis</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Skeleton and joints</subject><subject>Tibia</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0022-0795</issn><issn>1479-6805</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFv1DAQhS0EokvhyBX5Qm8pdhzH8RFVpSBV4gJny3YmG5dsbGyHhX-PS0JXQionP1nfezOjh9BrSi5pK8S7Ow-XRQpGGiKeoB1thKzajvCnaEdIXVdESH6GXqR0RwjlBXyOzmhNWl4zskPpOuXo9zDjCBZC9rHSUxg11nOPKwO5qAgYfoYIKUGP8xj9sh_9knHwKc866wn38AMmHw4wZ-zmwgCOOv_JiNoYl_E--mMecZh0hpfo2aCnBK-29xx9_XD95epjdfv55tPV-9vKcClzRTWT3DZisIx3krQGmJGyIZySulzZgwHR94zVLdey7QQBqFvZk4a1lpoO2Dmq1tx0hLAYFaI76PhLee3U9vWtKFBcMlGTwotH-RB9fzL9NVLJ2o6z4rxYnQX7vkDK6uCShWnSM_glKUG7kl_GPKxko08pwvAwhBJ136cqfaoi1z4L_2YLXswB-hO9FViAtxugk9XTEPVsXTpx5TDOm3uuWbnR7ceji6CM88m60pgbnNWPzmer7R_6_1v_BsW-zac</recordid><startdate>20020601</startdate><enddate>20020601</enddate><creator>Nilsson, O</creator><creator>Abad, V</creator><creator>Chrysis, D</creator><creator>Ritzen, EM</creator><creator>Savendahl, L</creator><creator>Baron, J</creator><general>BioScientifica</general><general>Portland Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>20020601</creationdate><title>Estrogen receptor-alpha and -beta are expressed throughout postnatal development in the rat and rabbit growth plate</title><author>Nilsson, O ; Abad, V ; Chrysis, D ; Ritzen, EM ; Savendahl, L ; Baron, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b599t-1a395c47fc358906be3b99405102147debe7dd33265a96870ee269d0436c1b8e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Aging - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chondrocytes - chemistry</topic><topic>Chondrocytes - metabolism</topic><topic>Estrogen Receptor alpha</topic><topic>Estrogen Receptor beta</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Growth Plate - chemistry</topic><topic>Growth Plate - metabolism</topic><topic>Humerus</topic><topic>Immunohistochemistry - methods</topic><topic>Male</topic><topic>Medicin och hälsovetenskap</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Receptors, Estrogen - analysis</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Skeleton and joints</topic><topic>Tibia</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nilsson, O</creatorcontrib><creatorcontrib>Abad, V</creatorcontrib><creatorcontrib>Chrysis, D</creatorcontrib><creatorcontrib>Ritzen, EM</creatorcontrib><creatorcontrib>Savendahl, L</creatorcontrib><creatorcontrib>Baron, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Journal of endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nilsson, O</au><au>Abad, V</au><au>Chrysis, D</au><au>Ritzen, EM</au><au>Savendahl, L</au><au>Baron, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estrogen receptor-alpha and -beta are expressed throughout postnatal development in the rat and rabbit growth plate</atitle><jtitle>Journal of endocrinology</jtitle><addtitle>J Endocrinol</addtitle><date>2002-06-01</date><risdate>2002</risdate><volume>173</volume><issue>3</issue><spage>407</spage><epage>414</epage><pages>407-414</pages><issn>0022-0795</issn><eissn>1479-6805</eissn><coden>JOENAK</coden><abstract>Estrogen regulates skeletal growth and promotes epiphyseal fusion. To explore the mechanisms underlying these effects we investigated the expression of estrogen receptor-alpha (ERalpha) and -beta (ERbeta) in rat and rabbit growth plates during postnatal development, using immunohistochemistry. Immunoreactivity for ERalpha and ERbeta was observed in resting zone and proliferative zone chondrocytes at all ages studied for both rat (7, 14, 28 and 70 days of age) and rabbit (1, 7, 28 and 120 days of age). In the rat distal humerus and the rabbit proximal tibia, expression of both receptors in the hypertrophic zone was minimal at early ages, increasing only at the last time point prior to epiphyseal fusion. Expression was rarely seen in the hypertrophic zone of the rat proximal tibia, a growth plate that does not fuse until late in life. Therefore, we conclude that ERalpha and ERbeta are both expressed in the mammalian growth plate. The temporal and anatomical pattern suggests that ER expression in the hypertrophic zone in particular may play a role in epiphyseal fusion.</abstract><cop>Colchester</cop><pub>BioScientifica</pub><pmid>12065230</pmid><doi>10.1677/joe.0.1730407</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aging - physiology Animals Biological and medical sciences Chondrocytes - chemistry Chondrocytes - metabolism Estrogen Receptor alpha Estrogen Receptor beta Female Fundamental and applied biological sciences. Psychology Growth Plate - chemistry Growth Plate - metabolism Humerus Immunohistochemistry - methods Male Medicin och hälsovetenskap Rabbits Rats Rats, Sprague-Dawley Receptors, Estrogen - analysis Receptors, Estrogen - metabolism Skeleton and joints Tibia Vertebrates: osteoarticular system, musculoskeletal system |
| title | Estrogen receptor-alpha and -beta are expressed throughout postnatal development in the rat and rabbit growth plate |
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