Persistence of viral RNA in the brain of offspring to mice infected with influenza A/WSN/33 virus during pregnancy
Epidemiological studies have indicated an association between influenza A virus infections during fetal life and neuropsychiatric diseases. To study the potential for influenza A virus infections to cause nervous system dysfunctions, we describe a mouse model using intranasal instillation of the mou...
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| Veröffentlicht in: | Journal of neurovirology 2002-08, Vol.8 (4), p.353-357 |
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| container_title | Journal of neurovirology |
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| creator | Aronsson, Fredrik Lannebo, Charlotta Paucar, Martin Brask, Johan Kristensson, Krister Karlsson, Håkan |
| description | Epidemiological studies have indicated an association between influenza A virus infections during fetal life and neuropsychiatric diseases. To study the potential for influenza A virus infections to cause nervous system dysfunctions, we describe a mouse model using intranasal instillation of the mouse neuroadapted influenza A/WSN/33 strain in pregnant mice. Viral RNA and nucleoprotein were detected in fetal brains and the viral RNA persisted for at least 90 days of postnatal life. We have, thus, obtained evidence for transplacental passage of influenza virus in mice and the persistence of viral components in the brains of these animals into young adulthood. Journal of NeuroVirology (2002) 8, 353-357. |
| doi_str_mv | 10.1080/13550280290100480 |
| format | Article |
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To study the potential for influenza A virus infections to cause nervous system dysfunctions, we describe a mouse model using intranasal instillation of the mouse neuroadapted influenza A/WSN/33 strain in pregnant mice. Viral RNA and nucleoprotein were detected in fetal brains and the viral RNA persisted for at least 90 days of postnatal life. We have, thus, obtained evidence for transplacental passage of influenza virus in mice and the persistence of viral components in the brains of these animals into young adulthood. 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| language | eng |
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| source | MEDLINE; Taylor & Francis Journals Complete; SpringerLink Journals - AutoHoldings |
| subjects | Animals Brain - virology Brain Diseases - virology Female Infectious Disease Transmission, Vertical Influenza A virus - genetics Influenza A virus - isolation & purification Medicin och hälsovetenskap Mice Mice, Inbred C57BL Orthomyxoviridae Infections - complications Orthomyxoviridae Infections - mortality Orthomyxoviridae Infections - transmission Pregnancy RNA, Viral - analysis Survival Rate |
| title | Persistence of viral RNA in the brain of offspring to mice infected with influenza A/WSN/33 virus during pregnancy |
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