The effect of modulation of glutathione cellular content on busulphan-induced cytotoxicity on hematopoietic cells in vitro and in vivo

Busulphan is used in conditioning regimens prior to SCT. A relationship between exposure to busulphan, expressed as an area under the plasma concentration time curve (AUC), and effect and/or adverse effects, such as veno-occlusive disease (VOD), was reported. Exhaustion of glutathione (GSH) contribu...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2002-08, Vol.30 (3), p.141-147
Hauptverfasser:	HASSAN, Z, HELLSTRÖM-LINDBERG, E, ALSADI, S, EDGREN, M, HÄGGLUND, H, HASSAN, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Acetylcysteine - pharmacology Animals Antigens, CD34 Antineoplastic Agents, Alkylating - pharmacology Area Under Curve Biocompatibility Biological and medical sciences Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Busulfan Busulfan - pharmacology Buthionine sulfoximine Buthionine Sulfoximine - pharmacology CD34 antigen Cell Death - drug effects Colonies Colony-Forming Units Assay Concentration time Conditioning Cytotoxicity Disease prevention Drug toxicity and drugs side effects treatment Erythroid Precursor Cells - cytology Erythroid Precursor Cells - drug effects Exposure Glutathione Glutathione - pharmacology Glutathione - physiology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - drug effects Hemopoiesis Hepatocytes Humans Intracellular Intracellular levels Medical sciences Medicin och hälsovetenskap Mice Mice, Inbred BALB C Modulation Modulators Pharmacology. Drug treatments Progenitor cells Prophylaxis Stem cell transplantation Toxicity Toxicity: blood Veno-occlusive disease
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