Identification of Residues Critical for Regulation of Protein Stability and the Transactivation Function of the Hypoxia-inducible Factor-1α by the von Hippel-Lindau Tumor Suppressor Gene Product

Under normoxic conditions the hypoxia-inducible factor-1 alpha (HIF-1 alpha ) protein is targeted for degradation by the Von Hippel-Lindau (pVHL) tumor suppressor protein acting as an E3 ubiquitin ligase. Binding of pVHL to HIF-1 alpha is dependent on hydroxylation of specific proline residues by O...

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Veröffentlicht in:	The Journal of biological chemistry 2003-02, Vol.278 (9), p.6816-6823
Hauptverfasser:	Pereira, Teresa, Zheng, Xiaowei, Ruas, Jorge L., Tanimoto, Keiji, Poellinger, Lorenz
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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