Successful treatment of neuroborreliosis with ten day regimens
BACKGROUND.There have been few large reports of the treatment and outcome of neuroborreliosis in children. METHODS.All 203 children with symptoms, cerebrospinal fluid and serologic findings compatible with neuroborreliosis and treated at one of the four pediatric hospitals in Stockholm from 1994 thr...
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| Veröffentlicht in: | The Pediatric infectious disease journal 2002-12, Vol.21 (12), p.1142-1145 |
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| container_issue | 12 |
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| container_title | The Pediatric infectious disease journal |
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| creator | THORSTRAND, CARITA BELFRAGE, ERIK BENNET, RUTGER MALMBORG, PETTER ERIKSSON, MARGARETA |
| description | BACKGROUND.There have been few large reports of the treatment and outcome of neuroborreliosis in children.
METHODS.All 203 children with symptoms, cerebrospinal fluid and serologic findings compatible with neuroborreliosis and treated at one of the four pediatric hospitals in Stockholm from 1994 through 1996 were included. Children were treated with intravenous beta-lactam antibiotics or oral doxycycline for 10 days and followed until the resolution of symptoms.
RESULTS.At the end of treatment 58% and after 2 months 92% of the children had no symptoms. Cerebrospinal fluid findings had no statistically significant influence on the outcome. Facial paralysis persisted longer than other symptoms.
CONCLUSIONS.The prognosis of neuroborreliosis in children 2 months after treatment seems to be excellent with 10-day treatment regimens. |
| doi_str_mv | 10.1097/00006454-200212000-00011 |
| format | Article |
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METHODS.All 203 children with symptoms, cerebrospinal fluid and serologic findings compatible with neuroborreliosis and treated at one of the four pediatric hospitals in Stockholm from 1994 through 1996 were included. Children were treated with intravenous beta-lactam antibiotics or oral doxycycline for 10 days and followed until the resolution of symptoms.
RESULTS.At the end of treatment 58% and after 2 months 92% of the children had no symptoms. Cerebrospinal fluid findings had no statistically significant influence on the outcome. Facial paralysis persisted longer than other symptoms.
CONCLUSIONS.The prognosis of neuroborreliosis in children 2 months after treatment seems to be excellent with 10-day treatment regimens.</description><identifier>ISSN: 0891-3668</identifier><identifier>EISSN: 1532-0987</identifier><identifier>DOI: 10.1097/00006454-200212000-00011</identifier><identifier>PMID: 12488665</identifier><identifier>CODEN: PIDJEV</identifier><language>eng</language><publisher>Baltimore, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Administration, Oral ; Analysis of Variance ; Bacterial diseases ; Biological and medical sciences ; Borrelia infections ; Chi-Square Distribution ; Child ; Child, Preschool ; Dose-Response Relationship, Drug ; Doxycycline - administration & dosage ; Drug Administration Schedule ; Drug Therapy, Combination - administration & dosage ; Female ; Follow-Up Studies ; Human bacterial diseases ; Humans ; Infectious diseases ; Infusions, Intravenous ; Lactams - administration & dosage ; Lyme Neuroborreliosis - diagnosis ; Lyme Neuroborreliosis - drug therapy ; Lyme Neuroborreliosis - epidemiology ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Probability ; Retrospective Studies ; Severity of Illness Index ; Sweden - epidemiology ; Treatment Outcome ; Tropical bacterial diseases</subject><ispartof>The Pediatric infectious disease journal, 2002-12, Vol.21 (12), p.1142-1145</ispartof><rights>2002 Lippincott Williams & Wilkins, Inc.</rights><rights>2003 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4971-edee8ab65ee2710ce2478566c06341478fbd20564d342f1349490a83e62b54693</citedby><cites>FETCH-LOGICAL-c4971-edee8ab65ee2710ce2478566c06341478fbd20564d342f1349490a83e62b54693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14429750$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12488665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:1938109$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>THORSTRAND, CARITA</creatorcontrib><creatorcontrib>BELFRAGE, ERIK</creatorcontrib><creatorcontrib>BENNET, RUTGER</creatorcontrib><creatorcontrib>MALMBORG, PETTER</creatorcontrib><creatorcontrib>ERIKSSON, MARGARETA</creatorcontrib><title>Successful treatment of neuroborreliosis with ten day regimens</title><title>The Pediatric infectious disease journal</title><addtitle>Pediatr Infect Dis J</addtitle><description>BACKGROUND.There have been few large reports of the treatment and outcome of neuroborreliosis in children.
METHODS.All 203 children with symptoms, cerebrospinal fluid and serologic findings compatible with neuroborreliosis and treated at one of the four pediatric hospitals in Stockholm from 1994 through 1996 were included. Children were treated with intravenous beta-lactam antibiotics or oral doxycycline for 10 days and followed until the resolution of symptoms.
RESULTS.At the end of treatment 58% and after 2 months 92% of the children had no symptoms. Cerebrospinal fluid findings had no statistically significant influence on the outcome. Facial paralysis persisted longer than other symptoms.
CONCLUSIONS.The prognosis of neuroborreliosis in children 2 months after treatment seems to be excellent with 10-day treatment regimens.</description><subject>Administration, Oral</subject><subject>Analysis of Variance</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Borrelia infections</subject><subject>Chi-Square Distribution</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dose-Response Relationship, Drug</subject><subject>Doxycycline - administration & dosage</subject><subject>Drug Administration Schedule</subject><subject>Drug Therapy, Combination - administration & dosage</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Infusions, Intravenous</subject><subject>Lactams - administration & dosage</subject><subject>Lyme Neuroborreliosis - diagnosis</subject><subject>Lyme Neuroborreliosis - drug therapy</subject><subject>Lyme Neuroborreliosis - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Probability</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Sweden - epidemiology</subject><subject>Treatment Outcome</subject><subject>Tropical bacterial diseases</subject><issn>0891-3668</issn><issn>1532-0987</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kktv1DAURi1ERYfCX0DZwC7g92ODhKrykCqxoF1bjnPDhHriwTfRqP8el0k7q1ryQ9Y5vpY_E9Iw-pFRZz7R2rRUsuWUclYH2tbO2AuyYUrwljprXpINtY61Qmt7Tl4j_qmIkIy-IueMS2u1Vhvy-dcSIyAOS2rmAmHewTQ3eWgmWErucimQxowjNodx3jYzTE0f7psCv8dK4htyNoSE8HadL8jt16uby-_t9c9vPy6_XLdROsNa6AFs6LQC4IbRCFwaq7SOVNcb1fXQ9ZwqLXsh-cCEdNLRYAVo3impnbgg7fFcPMB-6fy-jLtQ7n0Oo1-37uoKvHJMSVt58yy_L7k_SY8ic8LWt63mh6NZsb8L4Ox3I0ZIKUyQF_SGG2Ol1RW0RzCWjFhgeCrCqH9IyT-m5J9S8v9Tquq7tcbS7aA_iWssFXi_AgFjSEMJUxzxxEnJnVG0cvLIHXKaoeBdWg5Q_BZCmrf-uV8i_gEzaKn4</recordid><startdate>200212</startdate><enddate>200212</enddate><creator>THORSTRAND, CARITA</creator><creator>BELFRAGE, ERIK</creator><creator>BENNET, RUTGER</creator><creator>MALMBORG, PETTER</creator><creator>ERIKSSON, MARGARETA</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope></search><sort><creationdate>200212</creationdate><title>Successful treatment of neuroborreliosis with ten day regimens</title><author>THORSTRAND, CARITA ; BELFRAGE, ERIK ; BENNET, RUTGER ; MALMBORG, PETTER ; ERIKSSON, MARGARETA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4971-edee8ab65ee2710ce2478566c06341478fbd20564d342f1349490a83e62b54693</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Administration, Oral</topic><topic>Analysis of Variance</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Borrelia infections</topic><topic>Chi-Square Distribution</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dose-Response Relationship, Drug</topic><topic>Doxycycline - administration & dosage</topic><topic>Drug Administration Schedule</topic><topic>Drug Therapy, Combination - administration & dosage</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Infusions, Intravenous</topic><topic>Lactams - administration & dosage</topic><topic>Lyme Neuroborreliosis - diagnosis</topic><topic>Lyme Neuroborreliosis - drug therapy</topic><topic>Lyme Neuroborreliosis - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Probability</topic><topic>Retrospective Studies</topic><topic>Severity of Illness Index</topic><topic>Sweden - epidemiology</topic><topic>Treatment Outcome</topic><topic>Tropical bacterial diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THORSTRAND, CARITA</creatorcontrib><creatorcontrib>BELFRAGE, ERIK</creatorcontrib><creatorcontrib>BENNET, RUTGER</creatorcontrib><creatorcontrib>MALMBORG, PETTER</creatorcontrib><creatorcontrib>ERIKSSON, MARGARETA</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>The Pediatric infectious disease journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>THORSTRAND, CARITA</au><au>BELFRAGE, ERIK</au><au>BENNET, RUTGER</au><au>MALMBORG, PETTER</au><au>ERIKSSON, MARGARETA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Successful treatment of neuroborreliosis with ten day regimens</atitle><jtitle>The Pediatric infectious disease journal</jtitle><addtitle>Pediatr Infect Dis J</addtitle><date>2002-12</date><risdate>2002</risdate><volume>21</volume><issue>12</issue><spage>1142</spage><epage>1145</epage><pages>1142-1145</pages><issn>0891-3668</issn><eissn>1532-0987</eissn><coden>PIDJEV</coden><abstract>BACKGROUND.There have been few large reports of the treatment and outcome of neuroborreliosis in children.
METHODS.All 203 children with symptoms, cerebrospinal fluid and serologic findings compatible with neuroborreliosis and treated at one of the four pediatric hospitals in Stockholm from 1994 through 1996 were included. Children were treated with intravenous beta-lactam antibiotics or oral doxycycline for 10 days and followed until the resolution of symptoms.
RESULTS.At the end of treatment 58% and after 2 months 92% of the children had no symptoms. Cerebrospinal fluid findings had no statistically significant influence on the outcome. Facial paralysis persisted longer than other symptoms.
CONCLUSIONS.The prognosis of neuroborreliosis in children 2 months after treatment seems to be excellent with 10-day treatment regimens.</abstract><cop>Baltimore, MD</cop><cop>Philadelphia, PA</cop><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>12488665</pmid><doi>10.1097/00006454-200212000-00011</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Administration, Oral Analysis of Variance Bacterial diseases Biological and medical sciences Borrelia infections Chi-Square Distribution Child Child, Preschool Dose-Response Relationship, Drug Doxycycline - administration & dosage Drug Administration Schedule Drug Therapy, Combination - administration & dosage Female Follow-Up Studies Human bacterial diseases Humans Infectious diseases Infusions, Intravenous Lactams - administration & dosage Lyme Neuroborreliosis - diagnosis Lyme Neuroborreliosis - drug therapy Lyme Neuroborreliosis - epidemiology Male Medical sciences Medicin och hälsovetenskap Probability Retrospective Studies Severity of Illness Index Sweden - epidemiology Treatment Outcome Tropical bacterial diseases |
| title | Successful treatment of neuroborreliosis with ten day regimens |
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